Northwestern vs USC Prediction and Pick, Week 11

Northwestern vs USC Prediction and Pick, Week 11. Place a bet on this CFB football game with the best odds.

Northwestern vs USC Prediction: Trends

• Over the past seven games, Northwestern has a record of 5-1-1 against the spread.
• There have been four of Northwestern’s last six games in which the total has been UNDER.
• In its last five games, Northwestern has a winning record of 4-1 against the spread.
• Over the course of its previous 20 games played away from home, Northwestern has a record of 5-15 SU.
• Within the past five games that Northwestern has played against a team from the Big Ten conference, the total has been under in four of those matchups.
• With Northwestern’s most recent five games played in November, the total has gone over in four of those contests.
• During the 11th week of the season, Northwestern had a record of 10-4 against the spread.
• In the last seven games that Northwestern has played as the underdog, the team has a record of 1-6SU.
• Over the past six games, Southern California has a record of 2-4 against the spread.
• There have been four of Southern California’s last six games in which the total has been UNDER.
• Southern California has a winning record of 7-2 in its previous 9 games.
• In its previous seven games played at home, Southern California has a winning record of 6-1 against the spread.
• In their last seven games versus a team from the Big Ten conference, Southern California has a winning record of 6-1 against the opponent.
• Four of Southern California’s most recent five games against opponents from the West Division division have resulted in the total going UNDER their expectations.
• There have been six of Southern California’s last seven games played in November that have resulted in the total going UNDER.
• Over the course of the last 12 games played in week 11, Southern California has a 9-3 overall record.
• In its previous 14 games played on a Friday, Southern California has a record of 4-10 against the spread.

Northwestern vs USC Prediction

Now we have the Northwestern vs USC Prediction for both teams.

This Week 11 matchup between Northwestern and USC brings together two teams that tend to approach games in very different ways, and the contrast in style is what makes this one particularly intriguing. Northwestern enters with one of the most disciplined, grind-it-out approaches in the Big Ten, leaning heavily on time of possession, situational defense, and the ability to limit mistakes when it matters most. Their recent trend against the spread, especially as an underdog, reflects their identity as a team that often plays tougher than the numbers suggest. Meanwhile, USC has embraced a high-powered offensive identity that thrives on explosive plays, vertical passing, and tempo, and despite some inconsistency, they’ve proven capable of overwhelming opponents when the offense gets rolling early. While both teams have hit unders frequently in recent weeks, that’s largely due to the matchups and defensive pacing; this game could come down to who dictates tempo first. Northwestern will want to slow this game down, bleed clock, and turn it into a methodical possession battle, while USC will aim to strike quickly and force the Wildcats to play from behind — a situation that does not favor them historically. When Northwestern can control pace, they are tough to put away. When they are forced to open up the offense, things can unravel.

For Northwestern, the key strength lies in their ability to sustain drives and control the football, as seen by their top-10 ranking in time of possession. The Wildcats can run the ball effectively, averaging nearly 188 rushing yards per game, and they rely on that ground attack to open up manageable passing situations. The defense is also the unit that gives them a chance here — ranked top-15 nationally in points allowed, they specialize in bending but not breaking, and have performed well against elite passing offenses before, including a stunning road win at Penn State earlier in the season. However, Northwestern’s offensive limitations are real. They don’t push the ball through the air effectively, ranking outside the top 115 in passing, and their margin for error is extremely small — turnovers, negative plays, or falling behind early often lead to long stretches of stalled drives. The Wildcats are also just 1-6 straight-up in their last seven games as an underdog, showing that while they cover spreads often, pulling outright upsets in these types of matchups is still rare. Their best shot at winning is to dictate pace early, avoid turnovers, pin USC deep, and shorten the game. If they can keep USC under 30 points, the path becomes realistic. If this turns into a shootout, Northwestern simply doesn’t have the firepower to keep up.

USC comes into this matchup with a vastly different approach and set of strengths. They are among the most explosive offenses in the country, ranking top-10 in scoring and near the top nationally in both yards per play and passing efficiency. This is a team built to score in bunches, run plays quickly, and leverage superior athleticism on the perimeter. They’ve also shown they can run the ball effectively when needed, averaging over 200 rushing yards per game. Their defense hasn’t been dominant, but it has taken steps forward, particularly against the pass, and is capable of creating havoc when playing with a lead. USC has been excellent at home, covering the spread in six of their last seven at the Coliseum, and they have historically performed well against Big Ten opponents. The path to victory for USC is straightforward: score early, force Northwestern out of their comfort zone, and make the Wildcats chase points — something they statistically struggle with. If USC controls momentum, this game could open up in the second half.

Northwestern vs USC Prediction: Head to Head

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Northwestern vs USC Prediction: Northwestern Last 10 Games

Northwestern vs USC Prediction: USC Last 10 Games

Northwestern vs USC Prediction: Northwestern Offense

Northwestern vs USC Prediction: USC Offense

✅ Our CFB Week 11 Pick: USC

All NFL Week 11 Predictions

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Northwestern vs USC Prediction and Pick, Week 11, by YouWager.lv.