Iowa State Cyclones vs Colorado Buffaloes Betting Prediction and Pick, Week 7
Iowa State Cyclones vs Colorado Buffaloes Betting Prediction and Pick, Week 7. Place a bet on this CFB football game with the best odds.
The matchup between the Iowa State Cyclones and the Colorado Buffaloes in Week 7 brings plenty of intrigue for bettors looking to capitalize on key trends and performance data.
Iowa State Cyclones vs Colorado Buffaloes Betting Prediction
Now we have the Iowa State Cyclones vs Colorado Buffaloes Betting Prediction for both teams.
When analyzing the matchup holistically, the Cyclones appear to have the edge in both metrics and momentum. Iowa State’s offensive efficiency, particularly in the passing game, aligns perfectly with the weaknesses in Colorado’s secondary. Additionally, Iowa State’s discipline — ranking among the top five nationally in fewest penalties and penalty yards — should help them avoid costly mistakes in what could be a tightly contested game early on. Colorado’s defense will need to step up in a major way, but their lack of pass rush (averaging just 1.5 sacks per game) and inability to contain big plays through the air make that unlikely. Expect Iowa State to set the tone early, sustain drives, and pull away late with a combination of clock control and efficient red-zone scoring.
Iowa State Cyclones vs Colorado Buffaloes Betting Prediction: Iowa State
Iowa State enters this game with strong momentum against the spread, covering in six of its last seven games overall and showing impressive discipline both offensively and defensively. Despite a recent loss to Cincinnati, the Cyclones have been a tough road team, going 9-2 straight up in their last 11 away contests. Offensively, Iowa State’s balance is its biggest strength — averaging over 248 passing yards and 151 rushing yards per game — a combination that has helped them consistently control the tempo of games. Their offensive line has been reliable, limiting turnovers and penalties, while the defense complements that with efficiency and composure, particularly against mid-tier offenses. The Cyclones have also shown that they can thrive in October, with four of their last five games in this month going over the total, suggesting a team that heats up as the season deepens.
Iowa State Cyclones vs Colorado Buffaloes Betting Prediction: Iowa State Trends
- In its last seven games, Iowa State has a winning record of 6-1 against the spread.
- Overall, Iowa State has a record of 5-2 against Colorado in its last seven games.
- In its last 16 games against Colorado, Iowa State has a record of 4-12 against it.
- Overall, Iowa State has a record of 9-2 on the road in its last 11 games.
- Over the course of its last five games, Iowa State has a losing record of 0-5 versus Colorado when playing on the road.
- During the last six games that Iowa State has played against opponents from the Big 12 conference, the total has gone over in four of those games.
- In four of Iowa State’s most recent five games played in the month of October, the total has been over.
- In its last seven games played in week 7, Iowa State has a perfect record against the spread.
Iowa State Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
10/04/25
|
@CIN
|
L 38-30
|
L-3.5
|
O54.5
|
L-128
|
|
9/27/25
|
ARI
|
W 39-14
|
W-7.5
|
O49.5
|
W-300
|
|
9/13/25
|
|
W 24-16
|
L-20.5
|
U55.5
|
W-1600
|
|
9/06/25
|
IOW
|
W 16-13
|
W-1.5
|
U45.5
|
W-105
|
|
8/30/25
|
SD
|
W 55-7
|
W-16.5
|
O47.5
|
W-720
|
|
8/23/25
|
@KST
|
W 24-21
|
W+3.5
|
U49.5
|
W+126
|
|
12/28/24
|
@MFL
|
W 42-41
|
W+1.5
|
O52.5
|
W-105
|
|
12/07/24
|
@ASU
|
L 45-19
|
L-1.0
|
O50.5
|
L-115
|
|
11/30/24
|
KST
|
W 29-21
|
W+1.0
|
U52.5
|
W-138
|
|
11/23/24
|
@UTH
|
W 31-28
|
W+9.5
|
O40.5
|
W-245
|
Iowa State Cyclones vs Colorado Buffaloes Betting Prediction: Iowa State Offense
Overall
| IAST Offense | Off. Rank | Stat | Def. Rank | COLO Defense |
|---|---|---|---|---|
| 31.33 | 56 | Points Scored | 76 | 24.83 |
| 248.33 | 56 | Passing Yards | 70 | 218.83 |
| 151.00 | 79 | Rushing Yards | 115 | 180.00 |
| 31:33 | 38 | Time on Field | 107 | 31:43 |
| 68.67 | 41 | Number of Plays | 93 | 68.50 |
| 5.82 | 69 | Yards Per Play | 99 | 5.82 |
Scoring
| IAST Offense | Off. Rank | Stat | Def. Rank | COLO Defense |
|---|---|---|---|---|
| 31.33 | 56 | Points Scored | 76 | 24.83 |
| 7.33 | 52 | First Quarter | 21 | 2.17 |
| 9.50 | 62 | Second Quarter | 94 | 8.33 |
| 7.00 | 48 | Third Quarter | 91 | 5.67 |
| 7.50 | 63 | Fourth Quarter | 115 | 8.67 |
Passing
| IAST Offense | Off. Rank | Stat | Def. Rank | COLO Defense |
|---|---|---|---|---|
| 248.33 | 56 | Passing Yards | 70 | 218.83 |
| 29.17 | 82 | Pass Attempts | 42 | 28.17 |
| 19.00 | 75 | Pass Completions | 37 | 16.67 |
| 2.00 | 83 | Sacks | 106 | 1.50 |
| 12.33 | 58 | Sack Yards | 20 | 8.17 |
| 13.07 | 28 | Yards Per Pass | 122 | 13.13 |
Rushing
| IAST Offense | Off. Rank | Stat | Def. Rank | COLO Defense |
|---|---|---|---|---|
| 151.00 | 79 | Rushing Yards | 115 | 180.00 |
| 39.50 | 32 | Rush Attempts | 116 | 40.33 |
| 3.82 | 102 | Yards Per Rush | 98 | 4.46 |
Turn Overs
| IAST Offense | Off. Rank | Stat | Def. Rank | COLO Defense |
|---|---|---|---|---|
| 0.33 | 21 | Interceptions | 121 | 0.33 |
| 1.00 | 61 | Fumbles | 15 | 1.67 |
| 0.50 | 77 | Fumbles Lost | 31 | 0.67 |
| 0.83 | 40 | Total Turnovers | 90 | 1.00 |
| 3.50 | 3 | Penalties | 73 | 5.83 |
| 28.83 | 5 | Penalty Yards | 58 | 55.00 |
Drives & Special Teams
| IAST Offense | Off. Rank | Stat | Def. Rank | COLO Defense |
|---|---|---|---|---|
| 31:33 | 38 | Time on Field | 107 | 31:43 |
| 68.67 | 41 | Number of Plays | 93 | 68.50 |
| 5.82 | 69 | Yards Per Play | 99 | 5.82 |
| 3.00 | 37 | Punts | 126 | 3.00 |
| 45.52 | 37 | Punt Average | 40 | 41.35 |
| 49.00 | 83 | Return Yards | 51 | 37.67 |
Iowa State Cyclones vs Colorado Buffaloes Betting Prediction: Colorado
On the other hand, the Colorado Buffaloes have struggled to find consistency, both in their recent performances and against the spread. Losing five of their last seven games ATS, Colorado’s offensive production has been unreliable, especially when facing disciplined defensive units like Iowa State’s. While the Buffaloes have found some success at home — going 5-0 straight up in their last five home games against Iowa State — the current iteration of this team lacks the same dominance. Their defense continues to be a major concern, allowing over 24 points per game and giving up more than 180 rushing yards per contest. Those numbers spell trouble against an Iowa State offense that loves to establish the run and control time of possession. Colorado’s recent trend of games staying under the total — seven of their last nine — reflects a team that has struggled to maintain offensive rhythm and finish drives. With the Buffaloes’ inability to capitalize on red-zone opportunities and their defensive vulnerabilities against balanced attacks, they face an uphill climb against a focused Iowa State squad.
Iowa State Cyclones vs Colorado Buffaloes Betting Prediction: Colorado Trends
- In seven of Colorado’s most recent nine games, the total has been underwritten.
- In its last seven games, Colorado has a record of 2-5 against the spread.
- During Colorado’s most recent six games versus Iowa State, the total has been over in four of those games.
- Four out of Colorado’s previous five games played at home have resulted in the total going UNDER.
- When playing at home versus Iowa State, Colorado has a perfect record of 5-0 straight up in their last five games.
- Over the course of Colorado’s last six games against opponents from the Big 12 conference, the total has been under in five of those games.
- In its previous five games played in October, Colorado has a straight-up record of 4-1.
- During the seventh week of the season, Colorado has a record of 6-14 on the road.
- In its previous 19 games played on a Saturday, Colorado has a record of 14-4-1 against the spread.
Colorado Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
10/04/25
|
@TCU
|
L 35-21
|
L+13.5
|
O53.5
|
L+340
|
|
9/27/25
|
BYU
|
L 24-21
|
W+4.5
|
U46.5
|
L+152
|
|
9/20/25
|
WYO
|
W 37-20
|
L-17.5
|
O47.5
|
W-1000
|
|
9/12/25
|
@HOU
|
L 36-20
|
L+2.5
|
O45.5
|
L+106
|
|
9/06/25
|
DEL
|
W 31-7
|
L-24.5
|
U49.5
|
W-2800
|
|
8/29/25
|
GT
|
L 27-20
|
L+3.5
|
U56.5
|
L+138
|
|
12/28/24
|
BYU
|
L 36-14
|
L-3.5
|
U53.5
|
L-156
|
|
11/29/24
|
OKS
|
W 52-0
|
W-15.5
|
U65.5
|
W-650
|
|
11/23/24
|
@KAN
|
L 37-21
|
L+7.0
|
U61.5
|
L-142
|
|
11/16/24
|
UTH
|
W 49-24
|
W+8.0
|
O59.5
|
W+230
|
Iowa State Cyclones vs Colorado Buffaloes Betting Prediction: Colorado Offense
Overall
| IAST Defense | Def. Rank | Stat | Off. Rank | COLO Offense |
|---|---|---|---|---|
| 18.17 | 31 | Points Scored | 89 | 25.00 |
| 195.17 | 47 | Passing Yards | 85 | 211.67 |
| 141.83 | 66 | Rushing Yards | 87 | 144.00 |
| 28:26 | 37 | Time on Field | 105 | 28:17 |
| 62.50 | 40 | Number of Plays | 123 | 60.83 |
| 5.39 | 65 | Yards Per Play | 65 | 5.85 |
Scoring
| IAST Defense | Def. Rank | Stat | Off. Rank | COLO Offense |
|---|---|---|---|---|
| 18.17 | 31 | Points Scored | 89 | 25.00 |
| 4.00 | 49 | First Quarter | 100 | 4.67 |
| 8.00 | 90 | Second Quarter | 48 | 10.33 |
| 2.17 | 22 | Third Quarter | 106 | 4.00 |
| 4.00 | 29 | Fourth Quarter | 87 | 6.00 |
Passing
| IAST Defense | Def. Rank | Stat | Off. Rank | COLO Offense |
|---|---|---|---|---|
| 195.17 | 47 | Passing Yards | 85 | 211.67 |
| 31.50 | 81 | Pass Attempts | 86 | 28.17 |
| 18.83 | 70 | Pass Completions | 93 | 17.50 |
| 1.33 | 118 | Sacks | 108 | 2.50 |
| 8.50 | 24 | Sack Yards | 23 | 18.17 |
| 10.36 | 38 | Yards Per Pass | 56 | 12.10 |
Rushing
| IAST Defense | Def. Rank | Stat | Off. Rank | COLO Offense |
|---|---|---|---|---|
| 141.83 | 66 | Rushing Yards | 87 | 144.00 |
| 31.00 | 27 | Rush Attempts | 104 | 32.67 |
| 4.58 | 102 | Yards Per Rush | 66 | 4.41 |
Turn Overs
| IAST Defense | Def. Rank | Stat | Off. Rank | COLO Offense |
|---|---|---|---|---|
| 1.00 | 36 | Interceptions | 103 | 1.00 |
| 1.33 | 37 | Fumbles | 54 | 1.00 |
| 0.50 | 57 | Fumbles Lost | 43 | 0.33 |
| 1.50 | 42 | Total Turnovers | 81 | 1.33 |
| 6.67 | 46 | Penalties | 40 | 5.33 |
| 61.67 | 32 | Penalty Yards | 52 | 48.83 |
Drives & Special Teams
| IAST Defense | Def. Rank | Stat | Off. Rank | COLO Offense |
|---|---|---|---|---|
| 28:26 | 37 | Time on Field | 105 | 28:17 |
| 62.50 | 40 | Number of Plays | 123 | 60.83 |
| 5.39 | 65 | Yards Per Play | 65 | 5.85 |
| 4.00 | 89 | Punts | 96 | 4.67 |
| 43.60 | 93 | Punt Average | 76 | 43.15 |
| 82.50 | 116 | Return Yards | 40 | 70.17 |
✅ Our CFB Week 7 Pick: Iowa State Cyclones
All CFB Week 7 Predictions
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Iowa State Cyclones vs Colorado Buffaloes Betting Prediction and Pick, Week 7, by YouWager.lv.