This is our Titans at Bills Betting preview and odds for the second week of the 2022 NFL regular season.

Titans at Bills Betting Odds

These are the Titans at Bills Betting Odds, brought to you by YouWager.lv:

• Point Spread: Bills -7.5, Titans +7.5
• Money Line: Bills -350, Titans +290
• Total: 51 Over/Under

Point Spread

When you place a bet on the spread, you are choosing either the favorite or the underdog to cover the points that have been assigned to each team.

In this case, the Bills are the home favorites at -7.5. This means that if you place a bet on Buffalo, the team needs to win the game by 8 points or more.

If they win but by less than that, you lose your bet.

If the Bills win the game but by less than 8 points, you lose your bet.

On the other hand, if you place a bet on the Titans, the team can lose the game by less than 8 points and you can still win your wager.

If the team losses the game by more than 8 points, you lose your bet.

Money Line

When you bet on the money line, you are just placing a bet on the team that you believe will win the game straight up or SU.

And, if you really want to get the best value for your cash, a bet on the underdog team will always pay more.

And the reason for that is that the risk is higher than if you place a bet on your favorite team.

In this case, you can make $290 for each $100 you get to risk.

And because the favorite is a safer bet, you have to risk a little more for a lesser return.

In this particular case, you can get $100 for each $350 you get to risk.

Total

The total for this game has been set at 51.

This means that you can bet on the combined score of the two teams at the end of the game to be over or under 51 points.

This is really a great betting option if you just want to get action on the case without rooting for any of the two teams involved.

Check out our NFL Week 2 betting preview.

Titans at Bills Betting Preview

This is our Titans at Bills Betting preview.

This game opened up with the Bills as 7-point favorites at home vs the Titans, and the line has remained just about the same since then.

Versus Tennessee last year, Buffalo was the favorite by six points but they actually ended up losing the game.

Back then, the two franchises combined for 67 points, completely destroying the 53.5 over/under for that game.

Read our Bills at Rams Week 1 betting preview.

Tennessee Titans Betting Trends

• Titans is 3-6 across the spread in their last nine games
• UNDER has hit in five of the last six games for the Titans
• Titans are 10-4 straight up in their last fourteen games
• Tennessee is 6-3 across the spread in their last nine games vs the Bills
• Titans are 10-4 straight up in their last fourteen vs the Bills
• OVER has hit in twelve of the Titans’ last fifteen matchups on the road
• Titans are 4-8 straight up in their last twelve games when visiting Buffalo to play the Bills
• UNDER has hit in four of the Titans’ last five matchups versus an AFC rival
• Titans are 6-13 across the spread in their previews of nineteen matchups versus an AFC rival
• Titans are 6-1 straight up in their previews of seven matchups played in the month of September

Check out our Giants at Titans week 1 preview.

Buffalo Bills Betting Trends

• Bills are 4-1-1 across the spread in their previous six matchups
• OVER has hit in five of the last seven games for the Bills
• Bills are 5-1 straight up in their previous six games
• Buffalo are 14-3 straight up in their previous seventeen matchups at home
• Bills are 8-4 straight up in their previous twelve matchups when performing at home vs the Titans
• Bills are 1-6 across the spread in their previous seven matchups versus a rival in the AFC
• Buffalo is 5-2 across the spread in their previous seven games that took place in the month of September
• OVER has hit in seven of the Bills’ previous ten matchups played in the second week of the NFL regular season
• UNDER has hit in four of the Bills’ previous five matchups that took place on a Monday, and at home

Thank you for checking out our Titans at Bills Betting preview, best of luck with your action on this game!