Here is our Bills at Rams Betting preview and odds for the game.

As usual, the opening game of the NFL regular season features a team that managed to make a deep run in the postseason vs the current Super Bowl champs.

This year is no different as the Bills are visiting SoFi Stadium to face the Rams on September 8, 2022.

Bills at Rams Betting Odds

Here are the Bills at Rams Betting Odds, brought to you by YouWager.lv:

TEAM	MONEYLINE	SPREAD	TOTAL
BUFFALO BILLS	-135	-2.5 -110	O 52 -110
LOS ANGELES RAMS	+115	+2.5 -110	U 52 -110

As you can see, the Bills are -2 favorites to take their first victory of the season on the road.

If you place a bet on Buffalo, then the Bills must win by 2 points or more for you to collect profits.

If Buffalo wins but for less than two points, you lose your bet.

The Rams, on the other hand, are +2 home underdogs. This means that LA can even lose the game by less than two points and you can still win your bet.

If LA loses but for more than 2 points, you will lose your wager on the Rams.

When it comes to the total, the over/under is set at 52. So, you can bet that the score of both teams combined at the end of the game is going to be under 52 points or over 52 points.

Check out our preview and odds for the Week 1 Patriots at Dolphins game.

Bills at Rams Betting Preview

Now let’s continue with the Bills at Rams Betting preview!

A while ago, the line for this game was set at Pick Em, but oddsmakers quickly refreshed those numbers after the news of Mathew Stafford’s elbow problems.

But, everyone at the Rams organization was downplaying the talks about Stafford’s elbow during the weekend.

This includes Stafford himself, who mentioned this after Saturday’s team practice: “I don’t know if you guys were watching, I felt like I could make any throw I wanted today.”

There is still some time left before this game takes place, and by the time the game starts, Stafford’s elbow situation can be just one more training camp story.

That being said, the markets are indeed reacting.

And, we all well know that the NFL is a quarterback-driven league.

So, with Stafford hurrying to get back in top shape before a game versus the top prospect to get the MVP, chances are that the Rams, even though they are playing at home, will struggle against Buffalo.

Bills at Rams Betting: NFL Futures

Now in our Bills at Rams Betting article, let’s talk about NFL Futures.

When it comes to the futures market, the Bills are the current favorites to win Super Bowl LVII at +600 while the Rams are +1000.

Buffalo is also favorites to win the AFC conference at +325, while the Rams are +450 to win the NFC, just behind the Bucs, and tied with the Packers.

When it comes to divisions, the Bills are again favorites to win the AFC East at -230, while the Rams are also the favorites to win the NFC West at +120.

And guess what?

Not surprisingly, it is Bills QB1 Josh Allen who’s the favorite to win the regular season MVP honors at +650.

Stats

Last but not least in our Bills at Rams Betting piece, some significant stats for both teams.

The very last time that Josh Allen faced LA was back in 2020 at Week 3.

Back then, Allen finished with 311 passing yards and 4 passing TDs for a 35-32 late victory.

The following season, the Rams managed to get the Lombardi Trophy.

Last season LA opened up with +2000 odds to win the Super Bowl, and the addition of veteran Matthew Stafford improved those odds to +1400.

Their odds got even better when they managed to trade for Von Miller.

LA went on to defeat Cincinnati 23-20 to crown themselves.

The Bills also had an outstanding season, which ended up with a very contested defeat to the Chiefs, in a game that most classify as the crown jewel of last season’s games.

This was a tough blow for Buffalo as this was the second straight season that they fell to Kansas City.

Head To Head

Now it’s time to check out the head to head between these two teams since the 1985 season:

Date	Winner	Winner H/A/N	Score	ATS Cover	O/U Result
09/27/20	Buffalo	Home	35-32	Buffalo -1.5	Over 46.5
10/09/16	Buffalo	Away	30-19	Buffalo -2.5	Over 41.5
12/09/12	LA Rams	Away	15-12	LA Rams +3.5	Under 42.5
09/28/08	Buffalo	Away	31-14	Buffalo -9.5	Over 43.5
11/21/04	Buffalo	Home	37-17	Buffalo Pk	Over 40.0
09/20/98	LA Rams	Away	34-33	LA Rams +4.5	Over 38.5
12/10/95	Buffalo	Away	45-27	Buffalo -3.0	Over 40.0
09/06/92	Buffalo	Home	40-7	Buffalo -11.0	Over 44.5
10/16/89	Buffalo	Home	23-20	Buffalo +3.5	Over 40.0

Thank you for checking out our Bills at Rams Betting preview, best of luck with your wagering action!