Buccaneers vs Bills Prediction and Pick, Week 11

The Week 11 matchup between the Tampa Bay Buccaneers and Buffalo Bills brings together two teams that have been trending in different directions but both remain in the playoff hunt. Tampa Bay comes into this one having built momentum behind a tough defense and a well-balanced offense that has shown flashes of brilliance this season. Meanwhile, the Bills have once again proven to be one of the league’s most explosive teams on both sides of the ball, led by their high-powered offense and an opportunistic defense that thrives on creating pressure and turnovers. Historically, this series has been competitive, with the two sides splitting their last six meetings dating back to 2009. The most recent matchup in 2023 saw Buffalo pull off a 24-18 home win, while Tampa won the prior contest in 2021 in overtime. Now, as both teams square off again, the Bills will look to assert dominance at home, while the Buccaneers aim to continue their recent stretch of strong play against top-tier opponents. With playoff positioning on the line, this matchup is set to be one of the week’s most intriguing battles.

For the Buccaneers, the story this season has been about resilience and efficiency. They’ve won five of their last seven games, including impressive victories over San Francisco and Seattle. Quarterback play has been consistent, with Tampa averaging nearly 225 passing yards per game—ranking 11th in the NFL. Their aerial attack has been supported by an offensive line that has limited turnovers (only 0.63 per game, fifth-best in the league) and protected the ball exceptionally well. However, the running game remains a concern, averaging just 98 yards per contest, and that could be a problem against Buffalo’s defense, which despite its recent struggles against the run, still limits teams through the air and forces opponents into long third-down situations. Tampa Bay’s defense will also play a pivotal role, particularly its top-10 rushing unit that allows only 92 yards per game. If they can slow down the Bills’ ground attack and keep Josh Allen contained in the pocket, Tampa has a real shot to pull off a road upset.

The Buffalo Bills, on the other hand, continue to display elite form on both sides of the ball. Offensively, they rank fourth in scoring, averaging nearly 30 points per game, and lead the league in rushing with an impressive 164 yards per contest. Josh Allen’s dual-threat ability has been a nightmare for defenses, as he’s complemented by a deep group of receivers and a resurgent run game that keeps opponents guessing. Buffalo’s defense, while inconsistent at times, remains one of the best in creating negative plays—ranking second in passing yards allowed (161.8 per game) and first in time of possession, holding opponents under 27 minutes on average. Their ability to dictate tempo and force opponents to play from behind has been key to their success. The Bills have also bounced back from midseason losses with back-to-back dominant wins, including a 40-9 blowout at Carolina and a statement victory over Kansas City. At home, where they’re one of the toughest teams to beat, Buffalo’s balance and physicality should give them the edge over a gritty but less explosive Buccaneers squad.

✅ Our Buccaneers vs Bills Pick: BILLS

Buccaneers vs Bills Prediction: Head to Head

Date	Opponent	Score	Spread	Total	Moneyline
8/23/25	@TB	BUF 23-19	TB-2.5	O37.5	TB-130
10/26/23	@BUF	BUF 24-18	BUF-10.0	U43.5	BUF-460
12/12/21	@TB	TB 33-27	TB-4.0	O53.5	TB-162
10/22/17	@BUF	BUF 30-27	NL	NL	NL
12/08/13	@TB	TB 27-6	NL	NL	NL
9/20/09	@BUF	BUF 33-20	NL	NL	NL
9/18/05	@TB	TB 19-3	NL	NL	NL

Date	Opponent	Score	Spread	Total	Moneyline
11/02/25	KC	W 28-21	W-2.5	O48.5	W-135
10/26/25	@CAR	W 40-9	W-7.0	O47.5	W-310
10/13/25	@ATL	L 24-14	L-5.5	U48.5	L-225
10/05/25	NE	L 23-20	L-8.5	U46.5	L-380
9/28/25	NO	W 31-19	L-12.5	O46.5	W-650
9/18/25	MIA	W 31-21	W-8.5	O48.5	W-380
9/14/25	@NYJ	W 30-10	W-8.5	U44.5	W-380
9/07/25	BAL	W 41-40	L-1.5	O51.5	W-122
1/26/25	@KC	L 32-29	L+1.5	O48.5	L+102
1/19/25	BAL	W 27-25	W-1.0	O51.5	W-117

Buccaneers vs Bills Prediction: Tampa Bay Offense

Buccaneers vs Bills Prediction: Buffalo Offense

Buccaneers vs Bills Prediction and Pick, Week 11, by YouWager.lv.