Iowa vs USC Prediction and Pick, Week 12

Iowa vs USC Prediction and Pick, Week 12. Place a bet on this CFB football game with the best odds.

Iowa vs USC Prediction: Trends

• The Iowa Hawkeyes have a record of 6-1 against the spread over the course of their last seven games.
• The Iowa Hawkeyes have recorded a winning record of 5-2 against the spread in their most recent seven games.
• Over the course of the last fourteen games that Iowa has played away from home, the total has been UNDER on ten of those occasions.
• With a record of 5-1 against the spread in its most recent six games versus opponents from the Big Ten conference, Iowa has accomplished this feat.
• The Iowa Hawkeyes have a record of 17-3 against the spread in their five most recent games played in the month of November.
• The Hawkeyes have a perfect record in the last six games that they have played in week 12 of the season.
• Iowa’s record against the spread is 5-1 after six games played on Saturdays. This is the team’s overall record.
• A winning record of 8-2 has been achieved by Southern California throughout the course of the last ten games.
• Southern California has a perfect 5-0 record in its last five games that have been played at home as of this writing.
• The most recent eight games that Southern California has played against teams from the Big Ten league have resulted in a 7-1 victory for the school.
• There have been four out of the previous six games that Southern California has played against opponents from the West Division division, and the total has gone UNDER in all of those games.
• There have been six of Southern California’s last eight games played in November that have resulted in the total going UNDER. Seven of these games have been played in November.
• Southern California has a record of 4-2 against the spread in its last six games played in week 12, which were all played in Los Angeles.
• The Southern California Golden Eagles have a record of 2-4 against the spread in their previous six games that have been played on Saturdays.

Iowa vs USC Prediction

Now we have the Iowa vs USC Prediction for both teams.

The Week 12 showdown between the Iowa Hawkeyes and the USC Trojans promises to be one of the most fascinating Big Ten matchups of the season. On one side, you have Iowa — a team built on physicality, discipline, and elite defense — and on the other, a high-flying USC offense that can score in bunches and thrives on explosive plays. Iowa enters this contest with an excellent record against the spread, especially in November, where they’ve gone 17-3 ATS over their last 20. They’ve been money in late-season games, and their defense continues to set the tone, ranking top-10 nationally in both scoring and total defense. On the flip side, USC’s offense is among the most dangerous in the country, putting up nearly 40 points per game behind a balanced attack that averages over 300 yards passing and 200 on the ground. This game features a true contrast in styles — Iowa’s grinding, efficient, and mistake-free approach versus USC’s tempo-driven, big-play offense. Both teams have legitimate postseason aspirations, and this contest could have major implications for conference standings and potential bowl positioning.

For Iowa, success starts with defense and ball control. The Hawkeyes are limiting opponents to just 13.6 points per game, the fifth-best mark in college football. Their defensive front has been dominant, holding teams to under 104 rushing yards per contest, and their secondary ranks fifth nationally, allowing only 146.7 passing yards. That balance has made Iowa one of the toughest teams to move the ball against, regardless of opponent. Offensively, Iowa doesn’t light up the scoreboard, averaging just under 30 points per game, but they do it efficiently and without mistakes — ranking 18th in fewest turnovers per game and first in fewest penalties. Their run game, led by a physical offensive line and a deep stable of backs, averages nearly 176 rushing yards per game. They’ve been particularly effective when controlling the clock, averaging over 31 minutes of possession per game. Iowa’s offense might not be flashy, but its efficiency paired with the Hawkeyes’ elite defense gives them the kind of formula that travels well — especially in big road matchups like this one.

USC, meanwhile, has been lighting up the scoreboard all year long and comes in averaging nearly 40 points per game — good for seventh in the nation. Their offense is incredibly well-balanced, averaging over 500 total yards per contest, and they can attack defenses in multiple ways. The Trojans’ passing game is electric, ranking 10th nationally at 303 yards per game, while their rushing attack adds another 200+ yards on the ground, giving them elite versatility. Quarterback play has been sharp, and the offensive line has done a solid job protecting him, allowing just one sack per game. However, USC’s defense has been a bit inconsistent, giving up 21.8 points per game and over 205 passing yards, which could allow Iowa to exploit some gaps with their ground game and play-action. The Trojans’ biggest edge will be playing at home, where they’re 5-0 in their last five games and have historically thrived in late-season matchups. If USC can get an early lead and force Iowa to throw, their speed and athleticism could tilt the game in their favor. Still, against a disciplined and physical Iowa defense, that’s easier said than done.

✅ Our CFB Week 12 Pick: IOWA

Iowa vs USC Prediction: Head to Head

Iowa vs USC Prediction: Iowa Last 10 Games

Iowa vs USC Prediction: USC Last 10 Games

Iowa vs USC Prediction: Iowa Offense

Iowa vs USC Prediction: USC Offense

All NFL Week 12 Predictions

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Iowa vs USC Prediction and Pick, Week 12, by YouWager.lv.