Clemson vs Louisville Prediction and Pick, Week 12
Clemson vs Louisville Prediction and Pick, Week 12. Place a bet on this CFB football game with the best odds.
Clemson vs Louisville Prediction: Trends
- Over the past 14 games, Clemson has a record of 4-10 against the spread.
- Four of Clemson’s most recent six games have resulted in the total going over.
- The over/under record for Clemson’s previous seven games versus Louisville is 6-1.
- In its last nine games versus Louisville, Clemson has a consistent record of 8-1.
- Clemson has a winning record of 7-2 on the road in its last nine games.
- Over the course of its last 18 games versus teams from the Atlantic Coast conference, Clemson has a winning percentage of 13-5.
- Ten of the last thirteen games that Clemson has played against an opponent from the Atlantic Division division have resulted in the total going the UNDER.
- In its last five games played in November, Clemson has a head-to-head record of 1-4.
- On the road, Clemson has a record of 4-1 in its previous five games played in week 12.
- Over the past nine games, Louisville has a record of 3-6 against the spread.
- Overall, Louisville has a record of 10-2 in its previous 12 games.
- In its last six games played at home, Louisville has a record of 0-6 against the spread.
- This is Louisville’s seventh consecutive game versus a team from the Atlantic Coast conference, and they have a winning record of 5-2.
- Over the course of its previous seven games versus teams from the Atlantic Division, Louisville has a winning record of 6-1 as a team.
- In six of Louisville’s most recent nine games played in the month of November, the total has been overstated.
- After six games played in week 12, Louisville has a record of 5-1 against the spread.
- When Louisville has been the favorite in a game, the total has gone over in 12 of the last 18 games that they have played.
Clemson vs Louisville Prediction
Now we have the Clemson vs Louisville Prediction for both teams.
The Week 12 clash between the Clemson Tigers and the Louisville Cardinals brings two programs headed in slightly different directions but still fighting to establish control in the ACC. Clemson, despite flashes of its old dominance, has struggled to find consistency this season — especially against the spread, where they’ve gone just 4-10 over their last 14 games. The Tigers’ offense has leaned heavily on the passing attack, ranking 15th nationally in passing yards per game (288.4), but their rushing game has fallen flat at just 120.9 yards per contest, a surprising dip for a team historically built on balance. On the other side, Louisville’s recent record shows a strong straight-up mark (10-2 in their last 12) but poor ATS performance, particularly at home, where they’ve failed to cover in six straight. Both teams enter with offensive firepower and solid defensive units, but the trends suggest volatility: Clemson games tend to go over when facing Louisville (6-1 in the last seven matchups), and both offenses have been capable of quick strikes. The stakes are high here — Clemson wants to reaffirm its standing in the ACC, while Louisville aims to keep its home dominance alive, even if it hasn’t been kind to bettors lately.
For Clemson, this game is about restoring consistency after a rollercoaster stretch of results. The Tigers have been unpredictable, alternating between dominant defensive efforts and frustrating offensive lapses. Quarterback play has been solid in terms of yardage, with nearly 290 passing yards per game, but Clemson’s inability to finish drives has been an issue. Their red zone efficiency and rushing attack have lagged behind expectations, ranking outside the top 100 in yards per rush (3.83). Still, defensively, the Tigers remain stout against the run — allowing only 106 yards per game — which will be critical against a Louisville offense that thrives on ground balance. Historically, Clemson has dominated this matchup, winning eight of the last nine meetings, including last season’s 24-10 win over Florida State and strong road performances (7-2 in their last nine away games). If the Tigers can generate turnovers and find stability in their offensive line play, they’re more than capable of controlling tempo and forcing Louisville into uncomfortable situations. However, Clemson’s inconsistency in November (1-4 in their last five) makes this a real test of focus and discipline.
Louisville, meanwhile, continues to show flashes of a contender with an offense that’s both dynamic and well-balanced. The Cardinals are averaging 32.9 points per game and over 400 total yards, built on a productive backfield that gains 154.9 rushing yards per contest and a passing game that complements it well. The key to Louisville’s success will be finding ways to move the ball against Clemson’s fast front seven and limiting costly turnovers, as they’ve averaged 1.56 per game this season. Despite struggling against the spread at home, Louisville has won 10 of its last 12 games outright and owns a strong 6-1 record against ACC Atlantic foes. Quarterback efficiency and red zone execution will be vital, especially since Clemson’s defense has been vulnerable to big plays through the air, giving up 245 passing yards per game. The Cardinals have also been better in November (5-1 ATS in Week 12 matchups), and with home-field advantage, they could capitalize on Clemson’s uneven play. Expect a competitive, high-energy game, but Louisville’s offensive rhythm and Clemson’s passing attack both point toward a high-scoring outcome.
✅ Our CFB Week 12 Pick: LOUISVILLE
Clemson vs Louisville Prediction: Head to Head
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
11/02/24
|
@CLE
|
LOU 33-21
|
CLE-8.0
|
O52.5
|
CLE-300
|
|
11/12/22
|
@CLE
|
CLEM 31-16
|
CLE-13.5
|
U52
|
CLE-305
|
|
11/06/21
|
@LOU
|
CLEM 30-24
|
LOU+3.5
|
O45.5
|
LOU+142
|
|
10/19/19
|
@LOU
|
CLEM 45-10
|
LOU+24.5
|
U62.5
|
LOU+1150
|
|
11/03/18
|
@CLE
|
CLEM 77-16
|
NL
|
NL
|
NL
|
|
9/16/17
|
@LOU
|
CLEM 47-21
|
NL
|
NL
|
NL
|
|
10/01/16
|
@CLE
|
CLEM 42-36
|
NL
|
NL
|
NL
|
|
9/17/15
|
@LOU
|
CLEM 20-17
|
NL
|
NL
|
NL
|
Clemson vs Louisville Prediction: Clemson Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
11/08/25
|
FSU
|
W 24-10
|
W-2.5
|
U55.5
|
W-850
|
|
11/01/25
|
DUK
|
L 46-45
|
L-2.5
|
O54.5
|
L-134
|
|
10/18/25
|
SMU
|
L 35-24
|
L-10.5
|
O55.5
|
L-375
|
|
10/11/25
|
@BC
|
W 41-10
|
W-14.5
|
U53.5
|
W-550
|
|
10/04/25
|
@NC
|
W 38-10
|
W-12.5
|
U48.5
|
W-550
|
|
9/20/25
|
SYR
|
L 34-21
|
L-16.5
|
U55.5
|
L-720
|
|
9/13/25
|
@GT
|
L 24-21
|
L-8.5
|
U58.5
|
L-345
|
|
9/06/25
|
TRY
|
W 27-16
|
L-33.5
|
U51.5
|
W-30000
|
|
8/30/25
|
LSU
|
L 17-10
|
L-2.5
|
U56.5
|
L-140
|
|
12/21/24
|
@TEX
|
L 38-24
|
L+10.5
|
O52.5
|
L+300
|
Clemson vs Louisville Prediction: Louisville Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
11/08/25
|
CAL
|
L 29-26
|
L-18.5
|
O49.5
|
L-1450
|
|
11/01/25
|
@VT
|
W 28-16
|
L-15.5
|
U52.5
|
W-710
|
|
10/25/25
|
BC
|
W 38-24
|
L-22.5
|
O53.5
|
W-3000
|
|
10/17/25
|
@MFL
|
W 24-21
|
W+7.5
|
U51.5
|
W+500
|
|
10/04/25
|
UVA
|
L 30-27
|
L-7.5
|
U59.5
|
L-220
|
|
9/27/25
|
@PIT
|
W 34-27
|
W-6.5
|
O53.5
|
W-245
|
|
9/20/25
|
BGN
|
W 40-17
|
L-25.5
|
O51.5
|
W-4500
|
|
9/05/25
|
JM
|
W 28-14
|
L-14.5
|
U54.5
|
W-750
|
|
8/30/25
|
EKY
|
W 51-17
|
L-40.5
|
O56.5
|
W-12405
|
|
12/31/24
|
@WAS
|
W 35-34
|
L-5.0
|
O50.5
|
W-192
|
Clemson vs Louisville Prediction: Clemson Offense
Overall
| CLEM Offense | Off. Rank | Stat | Def. Rank | LOUIS Defense |
|---|---|---|---|---|
| 27.89 | 70 | Points Scored | 41 | 21.67 |
| 288.44 | 15 | Passing Yards | 28 | 188.11 |
| 120.89 | 112 | Rushing Yards | 22 | 108.67 |
| 30:45 | 43 | Time on Field | 55 | 29:27 |
| 67.78 | 52 | Number of Plays | 38 | 64.22 |
| 6.04 | 45 | Yards Per Play | 13 | 4.62 |
Scoring
| CLEM Offense | Off. Rank | Stat | Def. Rank | LOUIS Defense |
|---|---|---|---|---|
| 27.89 | 70 | Points Scored | 41 | 21.67 |
| 7.00 | 48 | First Quarter | 101 | 6.67 |
| 10.33 | 39 | Second Quarter | 31 | 5.67 |
| 5.22 | 85 | Third Quarter | 27 | 3.67 |
| 5.33 | 98 | Fourth Quarter | 24 | 4.33 |
Passing
| CLEM Offense | Off. Rank | Stat | Def. Rank | LOUIS Defense |
|---|---|---|---|---|
| 288.44 | 15 | Passing Yards | 28 | 188.11 |
| 36.22 | 20 | Pass Attempts | 84 | 31.44 |
| 24.22 | 17 | Pass Completions | 46 | 17.78 |
| 1.56 | 50 | Sacks | 60 | 2.11 |
| 9.56 | 93 | Sack Yards | 55 | 12.56 |
| 11.91 | 64 | Yards Per Pass | 25 | 10.58 |
Rushing
| CLEM Offense | Off. Rank | Stat | Def. Rank | LOUIS Defense |
|---|---|---|---|---|
| 120.89 | 112 | Rushing Yards | 22 | 108.67 |
| 31.56 | 113 | Rush Attempts | 31 | 32.78 |
| 3.83 | 103 | Yards Per Rush | 23 | 3.32 |
Turn Overs
| CLEM Offense | Off. Rank | Stat | Def. Rank | LOUIS Defense |
|---|---|---|---|---|
| 0.67 | 49 | Interceptions | 10 | 1.33 |
| 1.22 | 89 | Fumbles | 107 | 0.78 |
| 0.78 | 116 | Fumbles Lost | 82 | 0.44 |
| 1.44 | 89 | Total Turnovers | 21 | 1.78 |
| 4.56 | 15 | Penalties | 22 | 7.33 |
| 45.89 | 30 | Penalty Yards | 52 | 56.44 |
Drives & Special Teams
| CLEM Offense | Off. Rank | Stat | Def. Rank | LOUIS Defense |
|---|---|---|---|---|
| 30:45 | 43 | Time on Field | 55 | 29:27 |
| 67.78 | 52 | Number of Plays | 38 | 64.22 |
| 6.04 | 45 | Yards Per Play | 13 | 4.62 |
| 3.78 | 57 | Punts | 10 | 5.67 |
| 41.26 | 104 | Punt Average | 65 | 42.29 |
| 35.22 | 119 | Return Yards | 89 | 58.00 |
Clemson vs Louisville Prediction: Louisville Offense
Overall
| CLEM Defense | Def. Rank | Stat | Off. Rank | LOUIS Offense |
|---|---|---|---|---|
| 22.44 | 53 | Points Scored | 35 | 32.89 |
| 245.33 | 109 | Passing Yards | 50 | 246.56 |
| 106.33 | 20 | Rushing Yards | 71 | 154.89 |
| 29:14 | 49 | Time on Field | 51 | 30:32 |
| 67.22 | 86 | Number of Plays | 67 | 66.67 |
| 5.23 | 52 | Yards Per Play | 46 | 6.02 |
Scoring
| CLEM Defense | Def. Rank | Stat | Off. Rank | LOUIS Offense |
|---|---|---|---|---|
| 22.44 | 53 | Points Scored | 35 | 32.89 |
| 6.00 | 85 | First Quarter | 30 | 7.78 |
| 7.33 | 73 | Second Quarter | 57 | 9.33 |
| 3.44 | 23 | Third Quarter | 58 | 6.44 |
| 5.67 | 48 | Fourth Quarter | 29 | 8.67 |
Passing
| CLEM Defense | Def. Rank | Stat | Off. Rank | LOUIS Offense |
|---|---|---|---|---|
| 245.33 | 109 | Passing Yards | 50 | 246.56 |
| 37.33 | 133 | Pass Attempts | 24 | 36.00 |
| 22.56 | 126 | Pass Completions | 26 | 22.89 |
| 2.67 | 20 | Sacks | 85 | 2.00 |
| 16.44 | 98 | Sack Yards | 38 | 15.33 |
| 10.88 | 40 | Yards Per Pass | 98 | 10.77 |
Rushing
| CLEM Defense | Def. Rank | Stat | Off. Rank | LOUIS Offense |
|---|---|---|---|---|
| 106.33 | 20 | Rushing Yards | 71 | 154.89 |
| 29.89 | 4 | Rush Attempts | 120 | 30.67 |
| 3.56 | 32 | Yards Per Rush | 22 | 5.05 |
Turn Overs
| CLEM Defense | Def. Rank | Stat | Off. Rank | LOUIS Offense |
|---|---|---|---|---|
| 0.67 | 76 | Interceptions | 94 | 0.89 |
| 1.00 | 73 | Fumbles | 74 | 1.11 |
| 0.44 | 77 | Fumbles Lost | 102 | 0.67 |
| 1.11 | 84 | Total Turnovers | 106 | 1.56 |
| 6.22 | 59 | Penalties | 85 | 6.56 |
| 55.22 | 60 | Penalty Yards | 109 | 63.11 |
Drives & Special Teams
| CLEM Defense | Def. Rank | Stat | Off. Rank | LOUIS Offense |
|---|---|---|---|---|
| 29:14 | 49 | Time on Field | 51 | 30:32 |
| 67.22 | 86 | Number of Plays | 67 | 66.67 |
| 5.23 | 52 | Yards Per Play | 46 | 6.02 |
| 4.33 | 74 | Punts | 80 | 4.33 |
| 42.32 | 66 | Punt Average | 136 | 36.08 |
| 35.89 | 27 | Return Yards | 7 | 84.89 |
All NFL Week 12 Predictions
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Clemson vs Louisville Prediction and Pick, Week 12, by YouWager.lv.