Jaguars vs 49ers Betting Prediction Week 4, 2025
Jaguars vs 49ers Betting Prediction Week 4, 2025. Place a bet on this NFL football game with the best odds.
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The Week 4 clash between the Jacksonville Jaguars and San Francisco 49ers carries plenty of intrigue for bettors and fans alike.
Jaguars vs 49ers Betting Prediction
For bettors, this matchup presents a fascinating contrast. The Jaguars have shown improvement against the spread, covering in four of their last five games, but their dismal road record is difficult to ignore. San Francisco, while just 1-4 ATS at home recently, has a proven ability to win outright in these situations and has dominated the Jaguars historically. Total bettors should note that the UNDER has cashed consistently in head-to-head meetings, with six straight unders in this series. Ultimately, Jacksonville will need a near-flawless performance to keep pace with the 49ers’ passing attack, and unless they can establish the run early, San Francisco’s defense is likely to dictate the outcome. This looks like another opportunity for the Niners to flex their strength and continue their push as one of the NFC’s elite contenders.
Jaguars vs 49ers Betting Prediction: Head to Head
| Date | Team | Opp | Close | Result | ATS/OU |
|---|---|---|---|---|---|
| Nov 12, 2023 | 49ers | @Jaguars | -3 / 44.5 | Won 34-3 | Won / Under |
| Nov 21, 2021 | 49ers | @Jaguars | -6.5 / 45.5 | Won 30-10 | Won / Under |
| Dec 24, 2017 | 49ers | Jaguars | +4 / 43 | Won 44-33 | Won / Over |
| Oct 27, 2013 | 49ers | Jaguars | +16 / 40 | Lost 0-0 | Won / Under |
| Nov 29, 2009 | 49ers | @Jaguars | +3 / 42.5 | Lost 0-0 | Won / Under |
| Dec 18, 2005 | 49ers | Jaguars | -16 / 36.5 | Lost 0-0 | Lost / Under |
Jaguars vs 49ers Betting Prediction: Jacksonville
Jacksonville enters the game with a balanced offense, averaging over 140 rushing yards and 214 passing yards per contest. Their ability to control possession and run efficient plays has allowed them to stay competitive even in tough matchups. However, the Jaguars’ biggest obstacle continues to be their struggles on the road. With just one win in their last thirteen road games, Jacksonville faces a major uphill climb traveling across the country to face one of the NFC’s most disciplined teams. Their defense has been reliable, holding opponents to just 17 points per game, but facing a quarterback and passing unit as sharp as San Francisco’s will test that consistency to the fullest.
Jaguars vs 49ers Betting Prediction: Jacksonville Trends
- Over the past five games, Jacksonville has a record of 4-1 against the spread.
- In six of Jacksonville’s most recent nine games, the total has been reported as UNDER.
- Overall, Jacksonville has a record of 6-14 in its last 20 games.
- The over/under record for Jacksonville’s last six games versus San Francisco is a 0-6 record.
- The last five games that Jacksonville has played versus San Francisco have resulted in a losing record of 0-5 on the road.
- Overall, Jacksonville has a record of 1-12 on the road in its last 13 games.
- In Jacksonville’s last six games against teams from the National Football Conference, the Jaguars have a winning percentage of 1-5 against the opponent.
- When it comes to the National Football Conference West division, Jacksonville has a record of 0-6 against the spread in its last six games versus opponents.
- Five out of Jacksonville’s seven most recent games played in September have resulted in the total going UNDER.
- After seven games played in week 4, Jacksonville has a record of 5-2 against the spread.
Jacksonville Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
9/21/25
|
HOU
|
W 17-10
|
W-1.5
|
U46.5
|
W-127
|
|
9/14/25
|
@CIN
|
L 31-27
|
W+5.5
|
O49.5
|
L+198
|
|
9/07/25
|
CAR
|
W 26-10
|
W-2.5
|
U46.5
|
W-161
|
|
1/05/25
|
@IND
|
L 26-23
|
L+1.5
|
O46.5
|
L+102
|
|
12/29/24
|
TEN
|
W 20-13
|
W-4.0
|
U46
|
W-192
|
|
12/22/24
|
@LV
|
L 19-14
|
L-1.0
|
U45.5
|
L-115
|
|
12/15/24
|
NYJ
|
L 32-25
|
L+1.0
|
O46
|
L-105
|
|
12/08/24
|
@TEN
|
W 10-6
|
W-2.0
|
U45
|
W-125
|
|
12/01/24
|
HOU
|
L 23-20
|
L-1.0
|
U47
|
L-115
|
|
11/17/24
|
@DET
|
L 52-6
|
L+4.0
|
O50
|
L+160
|
Jaguars vs 49ers Betting Prediction: Jacksonville Offense
Overall
| JAC Offense | Off. Rank | Stat | Def. Rank | SF Defense |
|---|---|---|---|---|
| 23.33 | 14 | Points Scored | 3 | 16.33 |
| 214.67 | 13 | Passing Yards | 5 | 162.00 |
| 141.67 | 4 | Rushing Yards | 14 | 103.67 |
| 31:49 | 8 | Time on Field | 12 | 28:38 |
| 66.33 | 7 | Number of Plays | 15 | 60.33 |
| 5.37 | 13 | Yards Per Play | 5 | 4.40 |
Scoring
| JAC Offense | Off. Rank | Stat | Def. Rank | SF Defense |
|---|---|---|---|---|
| 23.33 | 14 | Points Scored | 3 | 16.33 |
| 5.67 | 11 | First Quarter | 2 | 0.00 |
| 9.00 | 8 | Second Quarter | 18 | 6.67 |
| 3.33 | 20 | Third Quarter | 15 | 3.33 |
| 5.33 | 26 | Fourth Quarter | 14 | 6.33 |
Passing
| JAC Offense | Off. Rank | Stat | Def. Rank | SF Defense |
|---|---|---|---|---|
| 214.67 | 13 | Passing Yards | 5 | 162.00 |
| 37.67 | 6 | Pass Attempts | 14 | 30.67 |
| 21.00 | 15 | Pass Completions | 16 | 21.00 |
| 1.00 | 3 | Sacks | 27 | 1.67 |
| 9.00 | 27 | Sack Yards | 8 | 10.00 |
| 10.22 | 13 | Yards Per Pass | 2 | 7.71 |
Rushing
| JAC Offense | Off. Rank | Stat | Def. Rank | SF Defense |
|---|---|---|---|---|
| 141.67 | 4 | Rushing Yards | 14 | 103.67 |
| 27.67 | 8 | Rush Attempts | 23 | 28.00 |
| 5.12 | 6 | Yards Per Rush | 7 | 3.70 |
Turn Overs
| JAC Offense | Off. Rank | Stat | Def. Rank | SF Defense |
|---|---|---|---|---|
| 1.33 | 29 | Interceptions | 31 | 0.00 |
| 0.33 | 6 | Fumbles | 3 | 2.00 |
| 0.00 | 6 | Fumbles Lost | 6 | 1.00 |
| 1.33 | 18 | Total Turnovers | 21 | 1.00 |
| 8.67 | 25 | Penalties | 28 | 5.33 |
| 72.67 | 29 | Penalty Yards | 30 | 35.00 |
Drives & Special Teams
| JAC Offense | Off. Rank | Stat | Def. Rank | SF Defense |
|---|---|---|---|---|
| 31:49 | 8 | Time on Field | 12 | 28:38 |
| 66.33 | 7 | Number of Plays | 15 | 60.33 |
| 5.37 | 13 | Yards Per Play | 5 | 4.40 |
| 3.33 | 12 | Punts | 7 | 4.67 |
| 49.88 | 8 | Punt Average | 23 | 49.16 |
| 101.00 | 26 | Return Yards | 7 | 108.00 |
Jaguars vs 49ers Betting Prediction: San Francisco
San Francisco is coming into this matchup with a perfect 3-0 start and a well-rounded identity that makes them one of the most difficult teams to prepare for. The 49ers’ passing game has been elite, averaging over 270 yards per outing and consistently moving the chains with efficiency. While their rushing attack has not been as strong, the Niners have made up for it with their ability to execute in late-game situations, posting an impressive nine points per fourth quarter on average. The defense has also been stout, limiting opponents to just 16.3 points per contest and under 4.5 yards per play. History favors San Francisco as well, as they have won five straight meetings against Jacksonville, including a 34-3 blowout in 2023.
Jaguars vs 49ers Betting Prediction: San Francisco Trends
- The over/under record for San Francisco’s last 12 games is 3-9.
- For San Francisco’s last six games, the total has been over in four of those games.
- When San Francisco has played Jacksonville in the past seven games, the total has been UNDER in five of those games.
- In its previous five games played at home, San Francisco has a record of 1-4 against the spread.
- There have been five out of San Francisco’s last seven games against opponents in the American Football Conference that have resulted in the total going over.
- San Francisco’s last five games against teams in the American Football Conference South division have all resulted with the total going UNDER in four of those games.
- In its previous ten games played in September, San Francisco has a head-to-head record of 8-2.
- After seven games played in week 4, San Francisco has a record of 5-2 against the spread.
- In the last six games that San Francisco has played on a Sunday, the team has a winning record of 4-2 against the spread.
San Francisco Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
9/21/25
|
ARI
|
W 16-15
|
L-3.5
|
U47.5
|
W-180
|
|
9/14/25
|
@NO
|
W 26-21
|
L-7.0
|
O44.5
|
W-340
|
|
9/07/25
|
@SEA
|
W 17-13
|
W-1.5
|
U45.5
|
W-124
|
|
1/05/25
|
@ARI
|
L 47-24
|
L-5.5
|
O43
|
L-230
|
|
12/30/24
|
DET
|
L 40-34
|
L-4.5
|
O49.5
|
L-205
|
|
12/22/24
|
@MIA
|
L 29-17
|
L-1.0
|
U49
|
L-115
|
|
12/12/24
|
LAR
|
L 12-6
|
L-7.0
|
U47.5
|
L-335
|
|
12/08/24
|
CHI
|
W 38-13
|
W-5.5
|
O47.5
|
W-230
|
|
12/01/24
|
@BUF
|
L 35-10
|
L-2.0
|
U47
|
L-125
|
|
11/24/24
|
@GB
|
L 38-10
|
L-2.5
|
O47
|
L-130
|
Jaguars vs 49ers Betting Prediction: San Francisco Offense
Overall
| JAC Defense | Def. Rank | Stat | Off. Rank | SF Offense |
|---|---|---|---|---|
| 17.00 | 7 | Points Scored | 23 | 19.67 |
| 209.33 | 16 | Passing Yards | 1 | 271.33 |
| 82.67 | 5 | Rushing Yards | 27 | 89.67 |
| 28:10 | 8 | Time on Field | 13 | 31:21 |
| 61.67 | 21 | Number of Plays | 4 | 67.33 |
| 4.74 | 8 | Yards Per Play | 14 | 5.36 |
Scoring
| JAC Defense | Def. Rank | Stat | Off. Rank | SF Offense |
|---|---|---|---|---|
| 17.00 | 7 | Points Scored | 23 | 19.67 |
| 3.33 | 9 | First Quarter | 21 | 4.33 |
| 2.00 | 2 | Second Quarter | 25 | 5.33 |
| 4.67 | 20 | Third Quarter | 30 | 1.00 |
| 7.00 | 19 | Fourth Quarter | 8 | 9.00 |
Passing
| JAC Defense | Def. Rank | Stat | Off. Rank | SF Offense |
|---|---|---|---|---|
| 209.33 | 16 | Passing Yards | 1 | 271.33 |
| 39.33 | 29 | Pass Attempts | 4 | 38.33 |
| 23.67 | 27 | Pass Completions | 5 | 26.33 |
| 2.00 | 21 | Sacks | 10 | 1.67 |
| 15.67 | 21 | Sack Yards | 28 | 8.67 |
| 8.85 | 9 | Yards Per Pass | 12 | 10.30 |
Rushing
| JAC Defense | Def. Rank | Stat | Off. Rank | SF Offense |
|---|---|---|---|---|
| 82.67 | 5 | Rushing Yards | 27 | 89.67 |
| 20.33 | 5 | Rush Attempts | 12 | 27.33 |
| 4.07 | 14 | Yards Per Rush | 28 | 3.28 |
Turn Overs
| JAC Defense | Def. Rank | Stat | Off. Rank | SF Offense |
|---|---|---|---|---|
| 2.33 | 1 | Interceptions | 26 | 1.00 |
| 0.67 | 19 | Fumbles | 22 | 1.00 |
| 0.67 | 8 | Fumbles Lost | 17 | 0.33 |
| 3.00 | 1 | Total Turnovers | 21 | 1.33 |
| 4.67 | 30 | Penalties | 13 | 6.33 |
| 43.33 | 27 | Penalty Yards | 12 | 56.67 |
Drives & Special Teams
| JAC Defense | Def. Rank | Stat | Off. Rank | SF Offense |
|---|---|---|---|---|
| 28:10 | 8 | Time on Field | 13 | 31:21 |
| 61.67 | 21 | Number of Plays | 4 | 67.33 |
| 4.74 | 8 | Yards Per Play | 14 | 5.36 |
| 3.67 | 17 | Punts | 11 | 3.00 |
| 46.63 | 10 | Punt Average | 27 | 44.14 |
| 95.33 | 5 | Return Yards | 30 | 77.67 |
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Jaguars vs 49ers Betting Prediction, NFL Week 18, by YouWager.lv.