Cardinals vs 49ers Predictions NFL Week 3 Picks, and Best Bets
Cardinals vs 49ers Predictions NFL Week 3. Place a bet on this NFL football game with the best lines and bonuses at YouWager.lv.
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The Arizona Cardinals and San Francisco 49ers enter Week 3 of the NFL season with very different betting profiles.
Cardinals vs 49ers Predictions NFL Week 3
This matchup also has an interesting history when it comes to totals. Six of the last seven meetings between these teams have gone over the posted number, suggesting a track record of high-scoring divisional clashes. Arizona’s defensive issues in stopping the pass, combined with San Francisco’s inconsistency in slowing down the run, point toward another game where points could come in bunches. Bettors will need to decide whether Arizona’s momentum and ATS strength outweigh San Francisco’s offensive firepower and desperation for a statement win at home.
Cardinals vs 49ers Predictions NFL Week 3: Head to Head
| Date | Team | Opp | Close | Result | ATS/OU |
|---|---|---|---|---|---|
| Jan 5, 2025 | 49ers | @Cardinals | +5.5 / 43.5 | Lost 24-47 | Lost / Over |
| Oct 6, 2024 | 49ers | Cardinals | -7.5 / 49 | Lost 23-24 | Lost / Under |
| Dec 17, 2023 | 49ers | @Cardinals | -12.5 / 48 | Won 45-29 | Won / Over |
| Oct 1, 2023 | 49ers | Cardinals | -15 / 44 | Won 35-16 | Won / Over |
| Jan 8, 2023 | 49ers | Cardinals | -14.5 / 39.5 | Won 38-13 | Won / Over |
| Nov 21, 2022 | 49ers | @Cardinals | -9.5 / 43 | Won 38-10 | Won / Over |
| Nov 7, 2021 | 49ers | Cardinals | -5.5 / 44.5 | Lost 17-31 | Lost / Over |
| Oct 10, 2021 | 49ers | @Cardinals | +5.5 / 48.5 | Lost 10-17 | Lost / Under |
| Dec 26, 2020 | 49ers | @Cardinals | +6 / 49 | Won 20-12 | Won / Under |
| Sep 13, 2020 | 49ers | Cardinals | -6.5 / 49.5 | Lost 20-24 | Lost / Under |
Cardinals vs 49ers Predictions NFL Week 3: Arizona
Now in this Cardinals vs 49ers Predictions NFL Week 3, we have the Arizona betting preview.
Arizona has been a strong team against the spread over the last year, going 9-4 in their past 13 games, and even pulled off a stunning 47-24 upset over San Francisco in January. The Cardinals have leaned on a balanced offense that mixes a solid run game with opportunistic passing, though they still rank just 27th in passing yards. Their ability to avoid costly mistakes, especially turnovers, has made them competitive in nearly every game, and their track record at Levi’s Stadium—seven wins in their last ten trips—suggests they can once again push the 49ers.
Cardinals vs 49ers Predictions NFL Week 3: Arizona Trends
Next in this Cardinals vs 49ers Predictions NFL Week 3, we have the Arizona trends:
- Over the course of its last 13 games, Arizona has accumulated a record of 9–4 against the spread.
- The total has gone over in five of Arizona’s last seven games.
- Over the course of its last six games, Arizona has had a record of 4 wins and 2 losses.
- In the last six games between Arizona and San Francisco, Arizona has achieved an ATS record of 2-4.
- In the past six games between the two teams, Arizona has a straight-up record of 2 wins and 4 losses.
- The total has gone under in four of Arizona’s last five games played away from home.
- When playing on the road versus San Francisco, Arizona has a record of seven wins and three losses in their last ten games.
- The total has gone OVER in four of the last six times that Arizona has faced a team from the National Football Conference.
- Arizona has a record of 4–16 in their previous twenty matchups versus teams that are in the National Football Conference West division.
- In the last nine games that Arizona has played in September, they have had an ATS record of 6–3.
Cardinals vs 49ers Predictions NFL Week 3: Arizona Picks and Best Bets
- Best Bet: Cardinals + points spread – Arizona has covered consistently.
- Secondary Bet: Over the total – 6 of last 7 meetings went over.
- Player Prop Angle: Look for Arizona’s rushing game to exceed expectations against a shaky front.
Arizona Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
9/14/25
|
CAR
|
W 27-22
|
W-4.5
|
O46.5
|
W-198
|
|
9/07/25
|
@NO
|
W 20-13
|
W-4.5
|
U41.5
|
W-200
|
|
1/05/25
|
SF
|
W 47-24
|
W+5.5
|
O43
|
W+190
|
|
12/28/24
|
@LAR
|
L 13-9
|
W+5.5
|
U48.5
|
L+195
|
|
12/22/24
|
@CAR
|
L 36-30
|
L-1.0
|
O45.5
|
L-118
|
|
12/15/24
|
NE
|
W 30-17
|
W-3.0
|
O44
|
W-155
|
|
12/08/24
|
SEA
|
L 30-18
|
L-1.0
|
O47.5
|
L-112
|
|
12/01/24
|
@MIN
|
L 23-22
|
W+1.5
|
U45.5
|
LEVEN
|
|
11/24/24
|
@SEA
|
L 16-6
|
L-1.0
|
U45.5
|
L-115
|
|
11/10/24
|
NYJ
|
W 31-6
|
W+3.0
|
U46.5
|
W+130
|
Cardinals vs 49ers Predictions NFL Week 3: Arizona Offense
Overall
| ARI Offense | Off. Rank | Stat | Def. Rank | SF Defense |
|---|---|---|---|---|
| 23.50 | 11 | Points Scored | 8 | 17.00 |
| 170.50 | 27 | Passing Yards | 6 | 166.00 |
| 114.00 | 13 | Rushing Yards | 13 | 102.50 |
| 30:15 | 17 | Time on Field | 4 | 25:38 |
| 54.50 | 27 | Number of Plays | 10 | 58.50 |
| 5.22 | 15 | Yards Per Play | 6 | 4.59 |
Scoring
| ARI Offense | Off. Rank | Stat | Def. Rank | SF Defense |
|---|---|---|---|---|
| 23.50 | 11 | Points Scored | 8 | 17.00 |
| 6.50 | 9 | First Quarter | 3 | 0.00 |
| 12.00 | 3 | Second Quarter | 21 | 8.50 |
| 5.00 | 6 | Third Quarter | 20 | 3.50 |
| 0.00 | 32 | Fourth Quarter | 12 | 5.00 |
Passing
| ARI Offense | Off. Rank | Stat | Def. Rank | SF Defense |
|---|---|---|---|---|
| 170.50 | 27 | Passing Yards | 6 | 166.00 |
| 27.00 | 26 | Pass Attempts | 12 | 28.50 |
| 19.00 | 24 | Pass Completions | 18 | 20.50 |
| 3.00 | 22 | Sacks | 21 | 2.00 |
| 21.00 | 7 | Sack Yards | 11 | 12.50 |
| 8.97 | 25 | Yards Per Pass | 3 | 8.10 |
Rushing
| ARI Offense | Off. Rank | Stat | Def. Rank | SF Defense |
|---|---|---|---|---|
| 114.00 | 13 | Rushing Yards | 13 | 102.50 |
| 24.50 | 20 | Rush Attempts | 24 | 28.00 |
| 4.65 | 11 | Yards Per Rush | 8 | 3.66 |
Turn Overs
| ARI Offense | Off. Rank | Stat | Def. Rank | SF Defense |
|---|---|---|---|---|
| 0.50 | 13 | Interceptions | 30 | 0.00 |
| 0.00 | 1 | Fumbles | 2 | 2.50 |
| 0.00 | 1 | Fumbles Lost | 1 | 1.50 |
| 0.50 | 7 | Total Turnovers | 10 | 1.50 |
| 10.50 | 30 | Penalties | 26 | 5.50 |
| 75.00 | 28 | Penalty Yards | 28 | 37.50 |
Drives & Special Teams
| ARI Offense | Off. Rank | Stat | Def. Rank | SF Defense |
|---|---|---|---|---|
| 30:15 | 17 | Time on Field | 4 | 25:38 |
| 54.50 | 27 | Number of Plays | 10 | 58.50 |
| 5.22 | 15 | Yards Per Play | 6 | 4.59 |
| 3.00 | 6 | Punts | 11 | 4.50 |
| 51.83 | 6 | Punt Average | 12 | 47.80 |
| 111.50 | 20 | Return Yards | 6 | 91.50 |
Cardinals vs 49ers Predictions NFL Week 3: San Francisco
Now in this Cardinals vs 49ers Predictions NFL Week 3, we have the San Francisco betting preview.
San Francisco, on the other hand, has been unreliable at the betting window. The 49ers are just 3-8 ATS in their last 11 and have struggled against NFC West opponents with a 2-6 record over their past eight divisional games. However, their offense has shown flashes, ranking sixth in the league in passing yards per game at 266, and they have one of the NFL’s best time-of-possession advantages. Their home-field record against Arizona, however, has been a point of concern, especially with five of the last seven games at Levi’s going over the total. That combination makes totals betting just as intriguing as picking a side.
Cardinals vs 49ers Predictions NFL Week 3: San Francisco Trends
Next in this Cardinals vs 49ers Predictions NFL Week 3, we have the San Francisco trends:
- Over the course of their most recent eleven games, San Francisco has achieved a win-loss record of 3 to 8 against the spread.
- The total has gone over in four out of the past five games played by San Francisco.
- The San Francisco team has a record of 3 wins and 7 losses over its most recent ten games.
- The total has gone over in six out of the last seven matches between Arizona and San Francisco.
- In its last sixteen home games, San Francisco has had an ATS record of 4-12.
- In five out of the past seven home games against Arizona, the total points scored in the match has gone OVER.
- The total has gone OVER in five of the past seven contests that San Francisco has played against a team in the National Football Conference.
- In their last eight matchups with a National Football Conference West team, San Francisco has had a record of two wins and six losses.
- Over the course of the last nine games that San Francisco has played in September, they have a win-loss record of 7 to 2.
- Over the course of the last thirteen games that they have played in week three, San Francisco has a record of three wins and ten losses.
Cardinals vs 49ers Predictions NFL Week 3: San Francisco Picks and Best Bets
- Best Bet: San Francisco moneyline – safer than spread given ATS struggles.
- Secondary Bet: Over the total – passing efficiency should help push this game high-scoring.
- Player Prop Angle: Target San Francisco passing overs, especially yardage props against Arizona’s defense.
San Francisco Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
9/14/25
|
@NO
|
W 26-21
|
L-7.0
|
O44.5
|
W-340
|
|
9/07/25
|
@SEA
|
W 17-13
|
W-1.5
|
U45.5
|
W-124
|
|
1/05/25
|
@ARI
|
L 47-24
|
L-5.5
|
O43
|
L-230
|
|
12/30/24
|
DET
|
L 40-34
|
L-4.5
|
O49.5
|
L-205
|
|
12/22/24
|
@MIA
|
L 29-17
|
L-1.0
|
U49
|
L-115
|
|
12/12/24
|
LAR
|
L 12-6
|
L-7.0
|
U47.5
|
L-335
|
|
12/08/24
|
CHI
|
W 38-13
|
W-5.5
|
O47.5
|
W-230
|
|
12/01/24
|
@BUF
|
L 35-10
|
L-2.0
|
U47
|
L-125
|
|
11/24/24
|
@GB
|
L 38-10
|
L-2.5
|
O47
|
L-130
|
|
11/17/24
|
SEA
|
L 20-17
|
L-9.0
|
U47.5
|
L-410
|
Cardinals vs 49ers Predictions NFL Week 3: San Francisco Offense
Overall
| ARI Defense | Def. Rank | Stat | Off. Rank | SF Offense |
|---|---|---|---|---|
| 17.50 | 10 | Points Scored | 19 | 21.50 |
| 255.50 | 26 | Passing Yards | 6 | 266.00 |
| 78.00 | 6 | Rushing Yards | 22 | 98.00 |
| 29:44 | 15 | Time on Field | 4 | 34:21 |
| 73.00 | 30 | Number of Plays | 3 | 70.00 |
| 4.57 | 5 | Yards Per Play | 16 | 5.20 |
Scoring
| ARI Defense | Def. Rank | Stat | Off. Rank | SF Offense |
|---|---|---|---|---|
| 17.50 | 10 | Points Scored | 19 | 21.50 |
| 1.50 | 4 | First Quarter | 13 | 6.50 |
| 5.00 | 9 | Second Quarter | 25 | 5.00 |
| 3.00 | 9 | Third Quarter | 28 | 1.50 |
| 8.00 | 19 | Fourth Quarter | 13 | 8.50 |
Passing
| ARI Defense | Def. Rank | Stat | Off. Rank | SF Offense |
|---|---|---|---|---|
| 255.50 | 26 | Passing Yards | 6 | 266.00 |
| 50.50 | 32 | Pass Attempts | 7 | 37.00 |
| 31.00 | 32 | Pass Completions | 6 | 26.00 |
| 2.00 | 16 | Sacks | 16 | 2.00 |
| 15.50 | 16 | Sack Yards | 21 | 12.00 |
| 8.24 | 4 | Yards Per Pass | 13 | 10.23 |
Rushing
| ARI Defense | Def. Rank | Stat | Off. Rank | SF Offense |
|---|---|---|---|---|
| 78.00 | 6 | Rushing Yards | 22 | 98.00 |
| 20.50 | 4 | Rush Attempts | 5 | 31.00 |
| 3.80 | 10 | Yards Per Rush | 29 | 3.16 |
Turn Overs
| ARI Defense | Def. Rank | Stat | Off. Rank | SF Offense |
|---|---|---|---|---|
| 0.50 | 11 | Interceptions | 23 | 1.00 |
| 0.50 | 17 | Fumbles | 28 | 1.50 |
| 0.50 | 8 | Fumbles Lost | 25 | 0.50 |
| 1.00 | 11 | Total Turnovers | 24 | 1.50 |
| 10.00 | 6 | Penalties | 18 | 7.00 |
| 86.00 | 5 | Penalty Yards | 12 | 50.50 |
Drives & Special Teams
| ARI Defense | Def. Rank | Stat | Off. Rank | SF Offense |
|---|---|---|---|---|
| 29:44 | 15 | Time on Field | 4 | 34:21 |
| 73.00 | 30 | Number of Plays | 3 | 70.00 |
| 4.57 | 5 | Yards Per Play | 16 | 5.20 |
| 3.00 | 21 | Punts | 12 | 3.00 |
| 49.50 | 21 | Punt Average | 28 | 44.87 |
| 135.50 | 20 | Return Yards | 32 | 63.50 |
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Cardinals vs 49ers Predictions NFL Week 3, by YouWager.lv.