Buffalo vs Central Michigan Prediction and Pick, Week 12
Buffalo vs Central Michigan Prediction and Pick, Week 12. Place a bet on this CFB football game with the best odds.
Buffalo vs Central Michigan Prediction: Trends
- Over the past seven games, Buffalo has a record of 1-5-1 against the spread.
- In four of Buffalo’s most recent six games, the total has been reported as UNDER.
- Buffalo has a winning record of 10-4 in its previous 14 games.
- The Buffalo Bills have a record of 4-8 versus Central Michigan in their last 12 games.
- Overall, Buffalo has a record of 5-1 on the road in its last six games.
- In its last nine games against teams from the Mid-American conference, Buffalo has a winning record of 8-1 versus the opponent.
- Six of Buffalo’s most recent six games against opponents from the West Division division have resulted in the total going over the point spread.
- After five games played in November, Buffalo has a record of 4-1 against the spread.
- On the road, Buffalo has a record of 0-9 in its last nine games played in week 12.
- Over the past six games, Central Michigan has a record of 5-1 against the spread.
- There have been six of Central Michigan’s last eight games in which the total has been above.
- In its previous six games, Central Michigan has a winning record of 4-2 against the spread.
- In each of Central Michigan’s last five games versus Buffalo, the total has been over in four of those contests.
- In its last six games played at home, Central Michigan has a perfect 6-0 record against the spread.
- With a total of seven games played against opponents from the Mid-American conference, Central Michigan has a record of 6-1 against the spread.
- In the last six games that Central Michigan has played against an opponent from the East Division, the team has a record of 1-5 on the road.
- After playing ten games in November, Central Michigan has a record of 1-9 against the spread.
- Twelve out of Central Michigan’s last fifteen games that have been played on a Wednesday have resulted in the total going over.
- All six of Central Michigan’s most recent seven games that have been played at home on a Wednesday have resulted in the total going over.
Buffalo vs Central Michigan Prediction
Now we have the Buffalo vs Central Michigan Prediction for both teams.
The Buffalo Bulls travel to Mount Pleasant to face the Central Michigan Chippewas in a pivotal Week 12 MAC showdown, where both teams are fighting to close out the season strong and gain late momentum. This matchup features two programs trending in different directions against the spread, but both have been competitive in conference play. Buffalo’s defense has quietly been one of the most efficient units in the MAC, allowing just 19.6 points per game, which ranks among the top 25 nationally. They’ve leaned heavily on their ability to control tempo, limit turnovers, and stay disciplined on the defensive front. Central Michigan, meanwhile, has been strong at home, covering the spread in all six of its most recent home contests, and its offense has been improving down the stretch behind a balanced rushing attack. This midweek MACtion clash sets up as a contrast in styles — Buffalo’s defensive efficiency and road resilience versus Central Michigan’s home-field dominance and ability to find offensive rhythm at Kelly/Shorts Stadium. Given how evenly matched these two are, turnovers, time of possession, and red-zone execution could ultimately determine who walks away victorious in Week 12.
For Buffalo, consistency has been a challenge, but their defense continues to give them a fighting chance in every game. The Bulls’ offense averages 24.8 points per game and is fairly balanced, posting 212 passing yards and 146 rushing yards per contest. While those aren’t eye-popping numbers, their success usually comes from taking care of the football and controlling drives. Quarterback play has been steady, with Buffalo ranking 89th in passing yards but excelling in protecting the quarterback, allowing just over one sack per game — a top-20 mark nationally. On the ground, their 4.19 yards per carry have been enough to keep defenses honest. The defense is where Buffalo truly shines, ranking 23rd in scoring defense and 25th in passing defense. They allow just 184 passing yards per game and have been particularly effective in the first half, limiting opponents to under seven points combined in the first two quarters. However, their struggles against the spread — just 1-5-1 in their last seven — and their inability to finish drives have hurt them. If Buffalo can find a rhythm offensively and sustain drives against a CMU defense that has been vulnerable at times, they’ll have a real shot to steal another road win.
Central Michigan enters this matchup as one of the more unpredictable teams in the MAC, but they’ve been a bettor’s friend recently, covering the spread in five of their last six. The Chippewas have been excellent at home, owning a perfect 6-0 ATS record at Kelly/Shorts Stadium. Their offense, while inconsistent, has shown big-play ability, averaging 185 rushing yards per game — good for 35th nationally. That ground attack, combined with timely scoring in the first half, has allowed them to build early leads and control the flow at home. Defensively, Central Michigan gives up just 24 points per game, but their secondary has shown vulnerability, ranking 47th against the pass. They’ll need to tighten up against a Buffalo team that tends to perform better on the road than at home. Still, CMU’s recent form — highlighted by a 38-13 win over UMass and a 27-6 win at Bowling Green — shows a team that can dominate when it executes its game plan. The key for CMU will be maintaining balance, avoiding turnovers, and forcing Buffalo to play from behind. Given their home success and strong recent ATS performance, the Chippewas enter this matchup with plenty of momentum and confidence.
✅ Our CFB Week 12 Pick: CENTRAL MICHIGAN
Buffalo vs Central Michigan Prediction: Head to Head
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
10/07/23
|
@BUF
|
BUF 37-13
|
BUF+1.0
|
U57.5
|
BUF+102
|
|
11/09/22
|
@CMC
|
CMC 31-27
|
CMC-1.0
|
O55.5
|
CMCEVEN
|
|
10/26/19
|
@BUF
|
BUF 43-20
|
BUF-2.5
|
O47.5
|
BUF-135
|
|
10/06/18
|
@CMC
|
BUF 34-24
|
NL
|
NL
|
NL
|
|
10/17/15
|
@CMC
|
CMC 51-14
|
NL
|
NL
|
NL
|
Buffalo vs Central Michigan Prediction: Buffalo Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
11/01/25
|
@BGN
|
W 28-3
|
W+1.5
|
U45.5
|
W-113
|
|
10/25/25
|
AKR
|
L 24-16
|
L-10.0
|
U47.5
|
L-345
|
|
10/18/25
|
@UMASS
|
W 28-21
|
L-17.0
|
O45.5
|
W-1200
|
|
10/04/25
|
EMC
|
W 31-30
|
L-10.0
|
O48.5
|
W-330
|
|
9/27/25
|
UCONN
|
L 20-17
|
L+1.5
|
U52
|
L+114
|
|
9/20/25
|
TRY
|
L 21-17
|
L-6.5
|
U43.5
|
L-235
|
|
9/13/25
|
@KNT
|
W 31-28
|
L-20.5
|
O48.5
|
W-2800
|
|
9/06/25
|
STF
|
W 45-6
|
W-33.5
|
O47.5
|
W-20000
|
|
8/28/25
|
@MIN
|
L 23-10
|
W+17.5
|
U45
|
L+680
|
|
1/04/25
|
@LIB
|
W 26-7
|
W+3.5
|
U51.5
|
W+138
|
Buffalo vs Central Michigan Prediction: Central Michigan Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
11/01/25
|
@WMC
|
L 24-21
|
W+6.0
|
U45.5
|
L+138
|
|
10/25/25
|
UMASS
|
W 38-13
|
W-16.5
|
O47.5
|
W-1000
|
|
10/18/25
|
@BGN
|
W 27-6
|
W+5.5
|
U43.5
|
W+205
|
|
10/04/25
|
@AKR
|
L 28-22
|
L-6.5
|
O45.5
|
L-220
|
|
9/27/25
|
EMC
|
W 24-13
|
W-4.5
|
U55.5
|
W-160
|
|
9/20/25
|
WAG
|
W 49-10
|
W-26.5
|
O44.5
|
W-7000
|
|
9/13/25
|
@MICH
|
L 63-3
|
L+29.5
|
O41.5
|
L+3000
|
|
9/06/25
|
@PIT
|
L 45-17
|
L+21.5
|
O53.5
|
L+980
|
|
8/29/25
|
|
W 16-14
|
W+11.5
|
U51.5
|
W+330
|
|
11/30/24
|
@NIL
|
L 24-16
|
W+13.5
|
U45.5
|
L+420
|
Buffalo vs Central Michigan Prediction: Buffalo Offense
Overall
| BUFF Offense | Off. Rank | Stat | Def. Rank | CMU Defense |
|---|---|---|---|---|
| 24.78 | 88 | Points Scored | 65 | 24.00 |
| 212.56 | 89 | Passing Yards | 47 | 203.67 |
| 146.22 | 80 | Rushing Yards | 85 | 154.11 |
| 28:22 | 112 | Time on Field | 20 | 27:51 |
| 67.44 | 57 | Number of Plays | 61 | 65.89 |
| 5.32 | 96 | Yards Per Play | 63 | 5.43 |
Scoring
| BUFF Offense | Off. Rank | Stat | Def. Rank | CMU Defense |
|---|---|---|---|---|
| 24.78 | 88 | Points Scored | 65 | 24.00 |
| 4.78 | 99 | First Quarter | 39 | 3.78 |
| 7.00 | 95 | Second Quarter | 94 | 8.67 |
| 8.00 | 26 | Third Quarter | 103 | 6.56 |
| 4.22 | 122 | Fourth Quarter | 37 | 5.00 |
Passing
| BUFF Offense | Off. Rank | Stat | Def. Rank | CMU Defense |
|---|---|---|---|---|
| 212.56 | 89 | Passing Yards | 47 | 203.67 |
| 32.56 | 50 | Pass Attempts | 80 | 31.22 |
| 19.22 | 75 | Pass Completions | 61 | 18.67 |
| 1.11 | 20 | Sacks | 78 | 1.89 |
| 6.00 | 121 | Sack Yards | 49 | 11.67 |
| 11.06 | 87 | Yards Per Pass | 43 | 10.91 |
Rushing
| BUFF Offense | Off. Rank | Stat | Def. Rank | CMU Defense |
|---|---|---|---|---|
| 146.22 | 80 | Rushing Yards | 85 | 154.11 |
| 34.89 | 75 | Rush Attempts | 61 | 34.67 |
| 4.19 | 77 | Yards Per Rush | 90 | 4.45 |
Turn Overs
| BUFF Offense | Off. Rank | Stat | Def. Rank | CMU Defense |
|---|---|---|---|---|
| 1.00 | 106 | Interceptions | 20 | 1.11 |
| 0.89 | 38 | Fumbles | 116 | 0.67 |
| 0.44 | 42 | Fumbles Lost | 98 | 0.33 |
| 1.44 | 88 | Total Turnovers | 40 | 1.44 |
| 5.22 | 33 | Penalties | 48 | 6.56 |
| 45.44 | 28 | Penalty Yards | 44 | 58.00 |
Drives & Special Teams
| BUFF Offense | Off. Rank | Stat | Def. Rank | CMU Defense |
|---|---|---|---|---|
| 28:22 | 112 | Time on Field | 20 | 27:51 |
| 67.44 | 57 | Number of Plays | 61 | 65.89 |
| 5.32 | 96 | Yards Per Play | 63 | 5.43 |
| 5.44 | 124 | Punts | 117 | 3.44 |
| 44.48 | 42 | Punt Average | 127 | 45.13 |
| 59.11 | 63 | Return Yards | 70 | 48.44 |
Buffalo vs Central Michigan Prediction: Central Michigan Offense
Overall
| BUFF Defense | Def. Rank | Stat | Off. Rank | CMU Offense |
|---|---|---|---|---|
| 19.56 | 23 | Points Scored | 92 | 24.11 |
| 184.22 | 25 | Passing Yards | 125 | 153.56 |
| 140.11 | 55 | Rushing Yards | 35 | 185.33 |
| 31:33 | 113 | Time on Field | 21 | 32:04 |
| 71.22 | 117 | Number of Plays | 129 | 61.11 |
| 4.55 | 12 | Yards Per Play | 79 | 5.55 |
Scoring
| BUFF Defense | Def. Rank | Stat | Off. Rank | CMU Offense |
|---|---|---|---|---|
| 19.56 | 23 | Points Scored | 92 | 24.11 |
| 1.89 | 5 | First Quarter | 31 | 7.67 |
| 5.00 | 17 | Second Quarter | 70 | 8.67 |
| 5.33 | 70 | Third Quarter | 83 | 5.33 |
| 6.67 | 73 | Fourth Quarter | 135 | 2.44 |
Passing
| BUFF Defense | Def. Rank | Stat | Off. Rank | CMU Offense |
|---|---|---|---|---|
| 184.22 | 25 | Passing Yards | 125 | 153.56 |
| 30.22 | 61 | Pass Attempts | 132 | 16.89 |
| 16.67 | 23 | Pass Completions | 132 | 11.78 |
| 3.22 | 7 | Sacks | 49 | 1.56 |
| 21.56 | 124 | Sack Yards | 86 | 10.11 |
| 11.05 | 53 | Yards Per Pass | 22 | 13.04 |
Rushing
| BUFF Defense | Def. Rank | Stat | Off. Rank | CMU Offense |
|---|---|---|---|---|
| 140.11 | 55 | Rushing Yards | 35 | 185.33 |
| 41.00 | 126 | Rush Attempts | 10 | 44.22 |
| 3.42 | 26 | Yards Per Rush | 78 | 4.19 |
Turn Overs
| BUFF Defense | Def. Rank | Stat | Off. Rank | CMU Offense |
|---|---|---|---|---|
| 0.44 | 109 | Interceptions | 4 | 0.22 |
| 1.44 | 20 | Fumbles | 69 | 1.11 |
| 0.67 | 30 | Fumbles Lost | 98 | 0.67 |
| 1.11 | 83 | Total Turnovers | 15 | 0.89 |
| 5.22 | 101 | Penalties | 83 | 6.56 |
| 37.78 | 123 | Penalty Yards | 64 | 53.44 |
Drives & Special Teams
| BUFF Defense | Def. Rank | Stat | Off. Rank | CMU Offense |
|---|---|---|---|---|
| 31:33 | 113 | Time on Field | 21 | 32:04 |
| 71.22 | 117 | Number of Plays | 129 | 61.11 |
| 4.55 | 12 | Yards Per Play | 79 | 5.55 |
| 6.56 | 3 | Punts | 75 | 4.22 |
| 42.13 | 59 | Punt Average | 121 | 39.88 |
| 35.33 | 25 | Return Yards | 116 | 37.22 |
All NFL Week 12 Predictions
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Buffalo vs Central Michigan Prediction and Pick, Week 12, by YouWager.lv.