49ers vs Cardinals Prediction and Pick, Week 11

49ers vs Cardinals Prediction and Pick, Week 11

49ers vs Cardinals Prediction and Pick, Week 11. Place a bet on this NFL football game with the best odds.

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49ers vs Cardinals Prediction

Now we have the 49ers vs Cardinals Prediction for both teams.

The Week 11 matchup between the San Francisco 49ers and Arizona Cardinals brings together two NFC West rivals who have seen their share of tight battles and surprising results over the past few seasons.

During the most recent week, the San Francisco 49ers continued their trend of zigzagging, as they have not won consecutive games since Weeks 2 and 3. The fact that you have a backup quarterback, that you are missing your WR1 and TE1 for a significant portion of those games, if not all of them, and that you no longer have your two greatest players on defense is something that is partly to be expected.

Following a loss to the Los Angeles Rams by a score of 42 points in Week 10, the 49ers’ defense reached its lowest point of the season. When you give up forty or more at home, there are no moral triumphs to be had. In spite of the fact that everyone in the NFL is suffering from injuries, it did not appear that the Niners had any chance of defending against that offense.

The good news for San Francisco is that they will be facing an Arizona Cardinals squad that, like them, has let up more than forty points to a team from the same division. There were two fumbles that were lost by Jacoby Brissett, and the Seattle Seahawks were already up 35-0 before Sam Darnold could even attempt a ball with a touchdown touchdown.

The Cardinals are currently in fourth place in the NFC West, while the 49ers are currently in third place. Week 11 is about to begin. According to FanDuel Sportsbook, the Niners are a 2.5-point favorite on the road, and the total is 48.5. The Niners’ defense has recently gained the attention of oddsmakers, as this is the second-highest total for Week 11 of the season.

Despite the fact that the 49ers have been mired in inconsistency since October, the Cardinals have triumphed once under the leadership of Brissett and Kyler Murray during that span of time. Arizona’s game against the Green Bay Packers was a competitive one throughout. However, after Monday Night Football, that is not exactly a prestigious accomplishment to be proud of. The victory over the Dallas Cowboys is completely unworthy of anything more than a yawn. Both the Panthers and the Bears were able to defeat the Cowboys.

What exactly are we going to witness this week? It is anticipated that Marvin Harrison Jr. and Trey McBride will present San Francisco with a defensive challenge. In Week 3, McBride racked up 78 yards while playing with Fred Warner.

As a result of their pass rush, the Cardinals have the advantage defensively; yet, the offense should continue to hum as a result of the likely return of Brock Purdy and Ricky Pearsall, as well as an offensive line that is heading in the right direction. Week 3 saw Mac Jones throw for 284 yards and a touchdown. The responsibility for 117 of those was borne by Pearsall.

In their most recent matchup, these two clubs finished with a score of 16-15. At this point in time, it may be the score at the halftime break.

Our 49ers vs Cardinals Pick: 49ERS

49ers vs Cardinals Odds

Now, we have the 49ers vs Cardinals odds:

TEAM SPREAD MONEYLINE TOTAL
49ers -2.5 -140 48.5 O
Cardinals +2.5 +120 48.5 U

49ers Futures Odds, and Cardinals Futures Odds

49ers Division Odds, and Cardinals Division Odds

Now, we have the 49ers Division Odds, and Cardinals Division Odds:

TEAM DIVISION ODDS
49ers Division Odds +1000
Cardinals Division Odds +40000

49ers NFC Championship Odds, and Cardinals NFC Championship Odds

Now, we have the 49ers NFC Championship Odds, and Cardinals NFC Championship Odds:

TEAM CONFERENCE ODDS
49ers NFC Championship Odds +1800
Cardinals NFC Championship Odds +25000

49ers vs Cardinals Prediction: Head to Head

Date Opponent Score Spread Total Moneyline
9/21/25
SF 16-15
SF-3.5
U47.5
SF-180
1/05/25
ARI 47-24
ARI+1.0
O47
ARI+190
10/06/24
ARI 24-23
SF-9.5
P47
SF-425
12/17/23
SF 45-29
ARI+6.5
O45.5
ARI+225
10/01/23
SF 35-16
SF-9.5
O43.5
SF-410
1/08/23
SF 38-13
SF-2.5
O40
SF-155
11/21/22
SF 38-10
ARI+1.5
U49
ARI+102
11/07/21
ARI 31-17
SF-5.0
O47
SF+130
10/10/21
ARI 17-10
ARI-5.0
U50
ARI-245
12/26/20
SF 20-12
ARI-6.0
U48.5
ARI-278

49ers vs Cardinals Prediction: San Francisco Last 10 Games

Date Opponent Score Spread Total Moneyline
11/02/25
W 34-24
W-3.5
O44.5
W-180
10/26/25
L 26-15
L-1.5
U45.5
L-120
10/19/25
W 20-10
W-6.5
U47.5
W-278
10/12/25
L 30-19
L+1.5
O47.5
L+102
10/02/25
W 26-23
W+1.5
O47.5
W+102
9/28/25
L 26-21
L-5.5
U48.5
L-218
9/21/25
W 16-15
L-3.5
U47.5
W-180
9/14/25
W 26-21
L-7.0
O44.5
W-340
9/07/25
W 17-13
W-1.5
U45.5
W-124
1/05/25
L 47-24
L-1.0
O47
L-230

49ers vs Cardinals Prediction: Arizona Last 10 Games

Date Opponent Score Spread Total Moneyline
11/03/25
W 27-17
W+1.5
U52.5
W+102
10/19/25
L 27-23
L+1.5
O47.5
LEVEN
10/12/25
L 31-27
L-1.5
O47.5
L-122
10/05/25
L 22-21
L-5.5
U46.5
L-225
9/25/25
L 23-20
L-2.5
U46.5
L-130
9/21/25
L 16-15
W+3.5
U47.5
L+150
9/14/25
W 27-22
W-4.5
O46.5
W-198
9/07/25
W 20-13
W-4.5
U41.5
W-200
1/05/25
W 47-24
W+1.0
O47
W+190
12/28/24
L 13-9
L+3.0
U49.5
L+195

49ers vs Cardinals Prediction: San Francisco Offense

Overall

SF Offense Off. Rank Stat Def. Rank ARI Defense
21.56 23 Points Scored 12 22.00
255.00 5 Passing Yards 24 234.86
97.11 26 Rushing Yards 12 100.86
30:54 14 Time on Field 7 28:19
65.56 3 Number of Plays 25 64.00
5.37 16 Yards Per Play 13 5.25

Scoring

SF Offense Off. Rank Stat Def. Rank ARI Defense
21.56 23 Points Scored 12 22.00
3.67 20 First Quarter 3 2.86
7.67 12 Second Quarter 7 5.57
3.44 23 Third Quarter 3 2.71
6.44 20 Fourth Quarter 30 10.86

Passing

SF Offense Off. Rank Stat Def. Rank ARI Defense
255.00 5 Passing Yards 24 234.86
35.89 6 Pass Attempts 30 38.00
24.00 3 Pass Completions 27 24.14
2.00 11 Sacks 26 1.71
13.67 20 Sack Yards 10 11.43
10.63 9 Yards Per Pass 8 9.73

Rushing

SF Offense Off. Rank Stat Def. Rank ARI Defense
97.11 26 Rushing Yards 12 100.86
27.67 9 Rush Attempts 10 24.29
3.51 32 Yards Per Rush 14 4.15

Turn Overs

SF Offense Off. Rank Stat Def. Rank ARI Defense
1.00 28 Interceptions 18 0.57
1.00 22 Fumbles 20 0.86
0.44 20 Fumbles Los49ers 9 0.43
1.44 25 Total Turnovers 17 1.00
6.00 5 Penalties 12 7.43
46.89 7 Penalty Yards 4 69.14

Drives & Special Teams

SF Offense Off. Rank Stat Def. Rank ARI Defense
30:54 14 Time on Field 7 28:19
65.56 3 Number of Plays 25 64.00
5.37 16 Yards Per Play 13 5.25
3.00 6 Punts 20 3.29
44.94 25 Punt Average 32 51.40
105.78 29 Return Yards 19 137.43

49ers vs Cardinals Prediction: Arizona Offense

Overall

SF Defense Def. Rank Stat Off. Rank ARI Offense
20.89 10 Points Scored 22 21.86
223.67 20 Passing Yards 21 199.86
108.89 15 Rushing Yards 20 110.43
29:48 12 Time on Field 8 31:40
61.00 14 Number of Plays 13 63.00
5.45 20 Yards Per Play 27 4.93

Scoring

SF Defense Def. Rank Stat Off. Rank ARI Offense
20.89 10 Points Scored 22 21.86
1.89 2 First Quarter 10 5.71
8.11 24 Second Quarter 20 6.71
5.56 23 Third Quarter 14 5.29
5.33 9 Fourth Quarter 31 4.14

Passing

SF Defense Def. Rank Stat Off. Rank ARI Offense
223.67 20 Passing Yards 21 199.86
33.67 20 Pass Attempts 10 34.57
22.89 23 Pass Completions 5 23.14
1.22 32 Sacks 28 3.43
8.00 2 Sack Yards 4 23.14
9.77 12 Yards Per Pass 28 8.64

Rushing

SF Defense Def. Rank Stat Off. Rank ARI Offense
108.89 15 Rushing Yards 20 110.43
26.11 17 Rush Attempts 24 25.00
4.17 15 Yards Per Rush 14 4.42

Turn Overs

SF Defense Def. Rank Stat Off. Rank ARI Offense
0.11 31 Interceptions 12 0.57
1.22 10 Fumbles 7 0.71
0.67 7 Fumbles LosCardinals 3 0.57
0.78 28 Total Turnovers 17 1.14
6.33 22 Penalties 26 7.71
42.56 29 Penalty Yards 19 56.14

Drives & Special Teams

SF Defense Def. Rank Stat Off. Rank ARI Offense
29:48 12 Time on Field 8 31:40
61.00 14 Number of Plays 13 63.00
5.45 20 Yards Per Play 27 4.93
3.78 10 Punts 19 3.57
49.48 28 Punt Average 5 50.87
140.00 23 Return Yards 20 121.00

 

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49ers vs Cardinals Prediction and Pick, Week 11, by YouWager.lv.

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