49ers vs Cardinals Prediction and Pick, Week 11
49ers vs Cardinals Prediction and Pick, Week 11. Place a bet on this NFL football game with the best odds.
49ers vs Cardinals Prediction
Now we have the 49ers vs Cardinals Prediction for both teams.
The Week 11 matchup between the San Francisco 49ers and Arizona Cardinals brings together two NFC West rivals who have seen their share of tight battles and surprising results over the past few seasons.
During the most recent week, the San Francisco 49ers continued their trend of zigzagging, as they have not won consecutive games since Weeks 2 and 3. The fact that you have a backup quarterback, that you are missing your WR1 and TE1 for a significant portion of those games, if not all of them, and that you no longer have your two greatest players on defense is something that is partly to be expected.
Following a loss to the Los Angeles Rams by a score of 42 points in Week 10, the 49ers’ defense reached its lowest point of the season. When you give up forty or more at home, there are no moral triumphs to be had. In spite of the fact that everyone in the NFL is suffering from injuries, it did not appear that the Niners had any chance of defending against that offense.
The good news for San Francisco is that they will be facing an Arizona Cardinals squad that, like them, has let up more than forty points to a team from the same division. There were two fumbles that were lost by Jacoby Brissett, and the Seattle Seahawks were already up 35-0 before Sam Darnold could even attempt a ball with a touchdown touchdown.
The Cardinals are currently in fourth place in the NFC West, while the 49ers are currently in third place. Week 11 is about to begin. According to FanDuel Sportsbook, the Niners are a 2.5-point favorite on the road, and the total is 48.5. The Niners’ defense has recently gained the attention of oddsmakers, as this is the second-highest total for Week 11 of the season.
Despite the fact that the 49ers have been mired in inconsistency since October, the Cardinals have triumphed once under the leadership of Brissett and Kyler Murray during that span of time. Arizona’s game against the Green Bay Packers was a competitive one throughout. However, after Monday Night Football, that is not exactly a prestigious accomplishment to be proud of. The victory over the Dallas Cowboys is completely unworthy of anything more than a yawn. Both the Panthers and the Bears were able to defeat the Cowboys.
What exactly are we going to witness this week? It is anticipated that Marvin Harrison Jr. and Trey McBride will present San Francisco with a defensive challenge. In Week 3, McBride racked up 78 yards while playing with Fred Warner.
As a result of their pass rush, the Cardinals have the advantage defensively; yet, the offense should continue to hum as a result of the likely return of Brock Purdy and Ricky Pearsall, as well as an offensive line that is heading in the right direction. Week 3 saw Mac Jones throw for 284 yards and a touchdown. The responsibility for 117 of those was borne by Pearsall.
In their most recent matchup, these two clubs finished with a score of 16-15. At this point in time, it may be the score at the halftime break.
✅ Our 49ers vs Cardinals Pick: 49ERS
49ers vs Cardinals Odds
Now, we have the 49ers vs Cardinals odds:
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| 49ers | -2.5 | -140 | 48.5 O |
| Cardinals | +2.5 | +120 | 48.5 U |
49ers Futures Odds, and Cardinals Futures Odds
49ers Division Odds, and Cardinals Division Odds
Now, we have the 49ers Division Odds, and Cardinals Division Odds:
| TEAM | DIVISION ODDS |
|---|---|
| 49ers Division Odds | +1000 |
| Cardinals Division Odds | +40000 |
49ers NFC Championship Odds, and Cardinals NFC Championship Odds
Now, we have the 49ers NFC Championship Odds, and Cardinals NFC Championship Odds:
| TEAM | CONFERENCE ODDS |
|---|---|
| 49ers NFC Championship Odds | +1800 |
| Cardinals NFC Championship Odds | +25000 |
49ers vs Cardinals Prediction: Head to Head
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
9/21/25
|
@SF
|
SF 16-15
|
SF-3.5
|
U47.5
|
SF-180
|
|
1/05/25
|
@ARI
|
ARI 47-24
|
ARI+1.0
|
O47
|
ARI+190
|
|
10/06/24
|
@SF
|
ARI 24-23
|
SF-9.5
|
P47
|
SF-425
|
|
12/17/23
|
@ARI
|
SF 45-29
|
ARI+6.5
|
O45.5
|
ARI+225
|
|
10/01/23
|
@SF
|
SF 35-16
|
SF-9.5
|
O43.5
|
SF-410
|
|
1/08/23
|
@SF
|
SF 38-13
|
SF-2.5
|
O40
|
SF-155
|
|
11/21/22
|
@ARI
|
SF 38-10
|
ARI+1.5
|
U49
|
ARI+102
|
|
11/07/21
|
@SF
|
ARI 31-17
|
SF-5.0
|
O47
|
SF+130
|
|
10/10/21
|
@ARI
|
ARI 17-10
|
ARI-5.0
|
U50
|
ARI-245
|
|
12/26/20
|
@ARI
|
SF 20-12
|
ARI-6.0
|
U48.5
|
ARI-278
|
49ers vs Cardinals Prediction: San Francisco Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
11/02/25
|
@NYG
|
W 34-24
|
W-3.5
|
O44.5
|
W-180
|
|
10/26/25
|
@HOU
|
L 26-15
|
L-1.5
|
U45.5
|
L-120
|
|
10/19/25
|
ATL
|
W 20-10
|
W-6.5
|
U47.5
|
W-278
|
|
10/12/25
|
@TB
|
L 30-19
|
L+1.5
|
O47.5
|
L+102
|
|
10/02/25
|
@LAR
|
W 26-23
|
W+1.5
|
O47.5
|
W+102
|
|
9/28/25
|
JAC
|
L 26-21
|
L-5.5
|
U48.5
|
L-218
|
|
9/21/25
|
ARI
|
W 16-15
|
L-3.5
|
U47.5
|
W-180
|
|
9/14/25
|
@NO
|
W 26-21
|
L-7.0
|
O44.5
|
W-340
|
|
9/07/25
|
@SEA
|
W 17-13
|
W-1.5
|
U45.5
|
W-124
|
|
1/05/25
|
@ARI
|
L 47-24
|
L-1.0
|
O47
|
L-230
|
49ers vs Cardinals Prediction: Arizona Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
11/03/25
|
@DAL
|
W 27-17
|
W+1.5
|
U52.5
|
W+102
|
|
10/19/25
|
GB
|
L 27-23
|
L+1.5
|
O47.5
|
LEVEN
|
|
10/12/25
|
@IND
|
L 31-27
|
L-1.5
|
O47.5
|
L-122
|
|
10/05/25
|
TEN
|
L 22-21
|
L-5.5
|
U46.5
|
L-225
|
|
9/25/25
|
SEA
|
L 23-20
|
L-2.5
|
U46.5
|
L-130
|
|
9/21/25
|
@SF
|
L 16-15
|
W+3.5
|
U47.5
|
L+150
|
|
9/14/25
|
CAR
|
W 27-22
|
W-4.5
|
O46.5
|
W-198
|
|
9/07/25
|
@NO
|
W 20-13
|
W-4.5
|
U41.5
|
W-200
|
|
1/05/25
|
SF
|
W 47-24
|
W+1.0
|
O47
|
W+190
|
|
12/28/24
|
@LAR
|
L 13-9
|
L+3.0
|
U49.5
|
L+195
|
49ers vs Cardinals Prediction: San Francisco Offense
Overall
| SF Offense | Off. Rank | Stat | Def. Rank | ARI Defense |
|---|---|---|---|---|
| 21.56 | 23 | Points Scored | 12 | 22.00 |
| 255.00 | 5 | Passing Yards | 24 | 234.86 |
| 97.11 | 26 | Rushing Yards | 12 | 100.86 |
| 30:54 | 14 | Time on Field | 7 | 28:19 |
| 65.56 | 3 | Number of Plays | 25 | 64.00 |
| 5.37 | 16 | Yards Per Play | 13 | 5.25 |
Scoring
| SF Offense | Off. Rank | Stat | Def. Rank | ARI Defense |
|---|---|---|---|---|
| 21.56 | 23 | Points Scored | 12 | 22.00 |
| 3.67 | 20 | First Quarter | 3 | 2.86 |
| 7.67 | 12 | Second Quarter | 7 | 5.57 |
| 3.44 | 23 | Third Quarter | 3 | 2.71 |
| 6.44 | 20 | Fourth Quarter | 30 | 10.86 |
Passing
| SF Offense | Off. Rank | Stat | Def. Rank | ARI Defense |
|---|---|---|---|---|
| 255.00 | 5 | Passing Yards | 24 | 234.86 |
| 35.89 | 6 | Pass Attempts | 30 | 38.00 |
| 24.00 | 3 | Pass Completions | 27 | 24.14 |
| 2.00 | 11 | Sacks | 26 | 1.71 |
| 13.67 | 20 | Sack Yards | 10 | 11.43 |
| 10.63 | 9 | Yards Per Pass | 8 | 9.73 |
Rushing
| SF Offense | Off. Rank | Stat | Def. Rank | ARI Defense |
|---|---|---|---|---|
| 97.11 | 26 | Rushing Yards | 12 | 100.86 |
| 27.67 | 9 | Rush Attempts | 10 | 24.29 |
| 3.51 | 32 | Yards Per Rush | 14 | 4.15 |
Turn Overs
| SF Offense | Off. Rank | Stat | Def. Rank | ARI Defense |
|---|---|---|---|---|
| 1.00 | 28 | Interceptions | 18 | 0.57 |
| 1.00 | 22 | Fumbles | 20 | 0.86 |
| 0.44 | 20 | Fumbles Los49ers | 9 | 0.43 |
| 1.44 | 25 | Total Turnovers | 17 | 1.00 |
| 6.00 | 5 | Penalties | 12 | 7.43 |
| 46.89 | 7 | Penalty Yards | 4 | 69.14 |
Drives & Special Teams
| SF Offense | Off. Rank | Stat | Def. Rank | ARI Defense |
|---|---|---|---|---|
| 30:54 | 14 | Time on Field | 7 | 28:19 |
| 65.56 | 3 | Number of Plays | 25 | 64.00 |
| 5.37 | 16 | Yards Per Play | 13 | 5.25 |
| 3.00 | 6 | Punts | 20 | 3.29 |
| 44.94 | 25 | Punt Average | 32 | 51.40 |
| 105.78 | 29 | Return Yards | 19 | 137.43 |
49ers vs Cardinals Prediction: Arizona Offense
Overall
| SF Defense | Def. Rank | Stat | Off. Rank | ARI Offense |
|---|---|---|---|---|
| 20.89 | 10 | Points Scored | 22 | 21.86 |
| 223.67 | 20 | Passing Yards | 21 | 199.86 |
| 108.89 | 15 | Rushing Yards | 20 | 110.43 |
| 29:48 | 12 | Time on Field | 8 | 31:40 |
| 61.00 | 14 | Number of Plays | 13 | 63.00 |
| 5.45 | 20 | Yards Per Play | 27 | 4.93 |
Scoring
| SF Defense | Def. Rank | Stat | Off. Rank | ARI Offense |
|---|---|---|---|---|
| 20.89 | 10 | Points Scored | 22 | 21.86 |
| 1.89 | 2 | First Quarter | 10 | 5.71 |
| 8.11 | 24 | Second Quarter | 20 | 6.71 |
| 5.56 | 23 | Third Quarter | 14 | 5.29 |
| 5.33 | 9 | Fourth Quarter | 31 | 4.14 |
Passing
| SF Defense | Def. Rank | Stat | Off. Rank | ARI Offense |
|---|---|---|---|---|
| 223.67 | 20 | Passing Yards | 21 | 199.86 |
| 33.67 | 20 | Pass Attempts | 10 | 34.57 |
| 22.89 | 23 | Pass Completions | 5 | 23.14 |
| 1.22 | 32 | Sacks | 28 | 3.43 |
| 8.00 | 2 | Sack Yards | 4 | 23.14 |
| 9.77 | 12 | Yards Per Pass | 28 | 8.64 |
Rushing
| SF Defense | Def. Rank | Stat | Off. Rank | ARI Offense |
|---|---|---|---|---|
| 108.89 | 15 | Rushing Yards | 20 | 110.43 |
| 26.11 | 17 | Rush Attempts | 24 | 25.00 |
| 4.17 | 15 | Yards Per Rush | 14 | 4.42 |
Turn Overs
| SF Defense | Def. Rank | Stat | Off. Rank | ARI Offense |
|---|---|---|---|---|
| 0.11 | 31 | Interceptions | 12 | 0.57 |
| 1.22 | 10 | Fumbles | 7 | 0.71 |
| 0.67 | 7 | Fumbles LosCardinals | 3 | 0.57 |
| 0.78 | 28 | Total Turnovers | 17 | 1.14 |
| 6.33 | 22 | Penalties | 26 | 7.71 |
| 42.56 | 29 | Penalty Yards | 19 | 56.14 |
Drives & Special Teams
| SF Defense | Def. Rank | Stat | Off. Rank | ARI Offense |
|---|---|---|---|---|
| 29:48 | 12 | Time on Field | 8 | 31:40 |
| 61.00 | 14 | Number of Plays | 13 | 63.00 |
| 5.45 | 20 | Yards Per Play | 27 | 4.93 |
| 3.78 | 10 | Punts | 19 | 3.57 |
| 49.48 | 28 | Punt Average | 5 | 50.87 |
| 140.00 | 23 | Return Yards | 20 | 121.00 |
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