Falcons vs Colts Prediction and Pick, Week 10

The Falcons vs Colts matchup in Week 10 presents a game of contrasting momentum and identity. Atlanta enters this one still searching for consistency, especially on the offensive side of the ball where they’ve shown flashes of potential but have struggled to maintain rhythm week to week. Meanwhile, Indianapolis has been one of the hottest teams in the league, winning seven of their last eight games with convincing performances on both sides of the ball. The head-to-head history favors Atlanta recently thanks to last year’s 29-10 win, but historically the Colts have controlled the rivalry. However, this game is less about history and more about the current form of these two teams. The Colts have been dominant offensively, ranking first in the league in points per game and demonstrating strong balance with a top-tier passing game and a top-10 rushing attack. Atlanta’s defense has been respectable, particularly in the passing game where they rank first in yards allowed, but they will be tested by the creativity and tempo of the Colts’ offense. The question becomes whether Atlanta can control time of possession, establish their run game early, and avoid turnovers to prevent the game from getting away from them.

For the Falcons, the path to victory starts with leaning heavily on their strength: the run game. Atlanta ranks fourth in the league in rushing yards per game, and when they are able to control the line of scrimmage and dictate tempo, their offense looks entirely different. However, their inconsistency at quarterback has made it difficult to sustain this approach against high-powered offenses. Atlanta has scored just 18.3 points per game, ranking near the bottom of the league, and their second-quarter production has been almost nonexistent, averaging only 3.8 points in that frame. That lack of offensive efficiency has put constant pressure on the defense, which, while strong in pass coverage, has been vulnerable against physical rushing attacks and late-game drives. To stay competitive here, the Falcons need sustained drives early, avoid falling behind, and force the Colts into longer possessions — because if this turns into a scoring race, Atlanta likely does not have the firepower to keep up. Their special teams and penalty discipline will also play a role, as they have been one of the least penalized offenses this season, something that could help them extend drives and stay within striking distance.

On the other side, the Colts have been rolling, powered by one of the most explosive and efficient offenses in the league. Averaging 33.1 points per game, Indianapolis has thrived on balance, tempo, and versatility. Their passing attack ranks fifth in the league, while their ground game sits at seventh, giving them the flexibility to adjust to any defensive look. The Colts also excel in the second and third quarters, where they average over 20 combined points between those two periods, meaning they have the ability to take control of games before the fourth quarter even begins. The challenge for the Colts in this matchup will be attacking Atlanta’s elite pass defense. However, with the Colts’ strong run game and their ability to use motion, play-action, and layered route concepts, they should be able to create mismatches. Defensively, Indianapolis has been stout overall, especially in the red zone, and their ability to force turnovers and disrupt timing could make life difficult for a Falcons offense that already struggles with consistency. If the Colts simply play to their strengths, they have the advantage in talent, momentum, and execution heading into this matchup.

Falcons vs Colts Prediction: Head to Head

Date	Opponent	Score	Spread	Total	Moneyline
12/24/23	@ATL	ATL 29-10	ATL-2.5	U42.5	ATL-130
9/22/19	@IND	IND 27-24	IND-1.5	O47	IND-122
11/22/15	@ATL	IND 24-21	NL	NL	NL
11/06/11	@IND	ATL 31-7	NL	NL	NL
11/22/07	@ATL	IND 31-13	NL	NL	NL
12/14/03	@IND	IND 38-7	NL	NL	NL

Date	Opponent	Score	Spread	Total	Moneyline
10/26/25	TEN	W 38-14	W-3.5	O44.5	W-175
10/19/25	@LAC	W 38-24	W+6.0	O45.5	W+195
10/12/25	ARI	W 31-27	W+1.5	O47.5	W+102
10/05/25	LV	W 40-6	W-1.5	O44.5	W-122
9/28/25	@LAR	L 27-20	L+6.5	U48.5	L+230
9/21/25	@TEN	W 41-20	W+1.5	O45.5	W+102
9/14/25	DEN	W 29-28	W+3.5	O44.5	W+145
9/07/25	MIA	W 33-8	W-1.5	U45.5	W-116
1/05/25	JAC	W 26-23	W-1.5	O46.5	W-122
12/29/24	@NYG	L 45-33	L-2.0	O43.5	L-130

Falcons vs Colts Prediction: Atlanta Offense

Falcons vs Colts Prediction: Indianapolis Offense

Falcons vs Colts Prediction and Pick, Week 10, by YouWager.lv.