Cardinals vs Seahawks Prediction and Pick, Week 10

This NFC West matchup has consistently been one of the more quietly intense rivalries in the division, and the history between these two teams has leaned heavily toward Seattle in recent years. Looking at the head-to-head results, the Seahawks have won seven of the last ten meetings, including a close 23-20 win earlier this season in Week 3. That trend fits how these teams often play each other: tough, physical games where defensive stops and late-game execution matter just as much as big plays. Arizona tends to keep games close but has struggled to finish in the final quarter, while Seattle has shown more late-game composure and resilience. Entering this Week 10 matchup, both teams are trending in different directions as well. The Cardinals are coming off a rough stretch, dropping three straight, while the Seahawks have won back-to-back games and appear to be stabilizing on both sides of the ball. When we look at the advanced metrics, Seattle’s defense has proven to be one of the better units in the league, particularly against the run, while the Cardinals have struggled to create explosive passing plays consistently. With divisional implications and momentum on the line, this game could be pivotal in shaping the middle of the NFC playoff race.

For Arizona, the frustration has been mounting, despite flashes of potential that suggest they’re not far from turning things around. Their offense ranks middle of the pack in both scoring and rushing efficiency, averaging just under 22 points per game, but they’ve struggled to generate chunk passing plays, ranking 29th in yards per pass attempt. The Cardinals do a solid job of staying balanced and controlling the clock — ranking 8th in time of possession — but these long drives haven’t translated into late-game scoring, particularly in the fourth quarter where they average only 4.14 points. Arizona’s inability to close games is evident in their recent losses; they’ve dropped multiple contests by a field goal or less, including the earlier matchup with Seattle. The defense hasn’t been bad, either. They sit 15th in scoring defense and have done a respectable job limiting explosive passing plays, but they’ve had issues defending efficient offenses in the second half. The main challenge for Arizona here will be sustaining drives without turnovers and forcing Seattle into uncomfortable third-down situations. If they can dictate pace and avoid the fourth-quarter collapses that have haunted them, they’ll have a chance — but recent form suggests that’s easier said than done.

Seattle, on the other hand, has shown steady offensive growth and efficiency. They’re scoring over 27 points per game, ranking top five offensively, and are one of the most explosive passing teams in the league, averaging a massive 12.86 yards per pass attempt. Their ability to stretch defenses vertically and create mismatches outside has allowed them to take control of games early, often jumping ahead in the first quarter. Meanwhile, the defense has been elite against the run, allowing just 75.71 rushing yards per contest, which is the best mark in the league. If Seattle forces Arizona into a pass-heavy script, it could turn into the kind of game where the Cardinals struggle to keep pace. One area to monitor, however, is Seattle’s fourth-quarter scoring and turnovers, as they have occasionally allowed teams to creep back in late. If Seattle protects the ball and plays to their identity — efficiency on offense, discipline on defense — they’ll likely control this game. They’ve already proven their ability to do so against this opponent earlier in the season.

Cardinals vs Seahawks Prediction: Head to Head

Date	Opponent	Score	Spread	Total	Moneyline
9/25/25	@ARI	SEA 23-20	ARI-2.5	U46.5	ARI-130
12/08/24	@ARI	SEA 30-18	ARI-1.0	O47.5	ARI-112
11/24/24	@SEA	SEA 16-6	SEA-1.0	U48.5	SEA-105
1/07/24	@ARI	SEA 21-20	ARI+4.5	U46.5	ARI+165
10/22/23	@SEA	SEA 20-10	SEA-7.0	U46	SEA-300
11/06/22	@ARI	SEA 31-21	ARI-7.0	O49	ARI-240
10/16/22	@SEA	SEA 19-9	SEA+3.0	U47	SEA+115
1/09/22	@ARI	SEA 38-30	ARI-5.0	O46.5	ARI-220
11/21/21	@SEA	ARI 23-13	SEA-3.5	U50.5	SEA-108
11/19/20	@SEA	SEA 28-21	SEA-3.0	U57	SEA-165

Date	Opponent	Score	Spread	Total	Moneyline
10/20/25	HOU	W 27-19	W-1.5	O44.5	W-122
10/12/25	@JAC	W 20-12	W+1.5	U46.5	W+102
10/05/25	TB	L 38-35	L+1.5	O47.5	L+102
9/25/25	@ARI	W 23-20	W+2.5	U46.5	W+110
9/21/25	NO	W 44-13	W-6.5	O43.5	W-258
9/14/25	@PIT	W 31-17	W+1.5	O43.5	W+102
9/07/25	SF	L 17-13	L+1.5	U45.5	L+106
1/05/25	@LAR	W 30-25	W+5.5	O47	W+185
12/26/24	@CHI	W 6-3	W-1.0	U40.5	W+145
12/22/24	MIN	L 27-24	L-2.0	O45.5	L-125

Cardinals vs Seahawks Prediction: Arizona Offense

Cardinals vs Seahawks Prediction: Seattle Offense

Cardinals vs Seahawks Prediction and Pick, Week 10, by YouWager.lv.