49ers vs Rams Betting Prediction and Pick Week 5, 2025
49ers vs Rams Betting Prediction Week 5, 2025. Place a bet on this NFL football game with the best odds.
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The San Francisco 49ers and Los Angeles Rams meet in Week 5 of the 2025 NFL season in a divisional battle that has massive implications for the NFC West.
49ers vs Rams Betting Prediction
Recent history between these two rivals has been back and forth, but the edge has shifted in favor of the Rams. San Francisco has dropped four of their last five games against Los Angeles, and their lack of offensive balance has become increasingly clear in these meetings. The Rams have also thrived at home against the 49ers, especially against the spread, making this matchup even tougher for San Francisco. Unless the 49ers can control the turnover battle and establish their running game, it’s hard to see them keeping pace with a Rams team firing on all cylinders. The divisional stakes are high, but Los Angeles looks poised to continue its hot start to the season with another big win.
49ers vs Rams Betting Prediction: Head to Head
| Date | Team | Opp | Close | Result | ATS/OU |
|---|---|---|---|---|---|
| Dec 12, 2024 | 49ers | Rams | -3 / 48.5 | Lost 6-12 | Lost / Under |
| Sep 22, 2024 | 49ers | @Rams | -6 / 44.5 | Lost 24-27 | Lost / Over |
| Jan 7, 2024 | 49ers | Rams | -5.5 / 40 | Lost 20-21 | Lost / Over |
| Sep 17, 2023 | 49ers | @Rams | -7.5 / 45 | Won 30-23 | Lost / Over |
| Oct 30, 2022 | 49ers | @Rams | +1 / 42 | Won 31-14 | Won / Over |
| Oct 3, 2022 | 49ers | Rams | -1.5 / 41.5 | Won 24-9 | Won / Under |
| Jan 30, 2022 | 49ers | @Rams | +3.5 / 45.5 | Lost 17-20 | Won / Under |
| Jan 9, 2022 | 49ers | @Rams | +3.5 / 46.5 | Won 27-24 | Won / Over |
| Nov 15, 2021 | 49ers | Rams | +3.5 / 50.5 | Won 31-10 | Won / Under |
| Nov 29, 2020 | 49ers | @Rams | +5 / 44.5 | Won 23-20 | Won / Under |
49ers vs Rams Betting Prediction: San Francisco
San Francisco enters the matchup with a talented passing game but plagued by turnovers and inconsistency on the ground. Their offensive line has struggled to open rushing lanes, and the 49ers are averaging just 3.3 yards per carry, one of the lowest marks in the league. While the defense has kept them competitive by holding opponents under 19 points on average, the offense has repeatedly left points on the field due to giveaways. The last time these two teams met, the 49ers were held to only six points, a concerning trend that highlights their struggles against this Rams defense.
49ers vs Rams Betting Prediction: San Francisco Trends
- The over/under record for San Francisco’s last 13 games is 3-10.
- Since San Francisco’s last seven games, the total has been over in five of those games.
- In its last 12 games, San Francisco has a record of 4-8 while SU.
- San Francisco has a record of 1-4 versus the Los Angeles Rams in their last five games.
- The San Francisco 49ers have a winning record of 9-4 versus the Los Angeles Rams in their last 13 games.
- In its last 11 games played away from home, San Francisco has a record of 3-8 against the spread.
- In four of San Francisco’s last five games against the Los Angeles Rams, the total has been over. These games have been played away from home.
- In the last 18 games that San Francisco has played against an opponent from the National Football Conference, the team has a record of 5-13 adjusted points.
- There have been four out of San Francisco’s last five games against opponents from the National Football Conference West division in which the total has been reported as UNDER.
- With seven games played in October, San Francisco has a record of 2-5 on the road.
San Francisco Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
9/28/25
|
JAC
|
L 26-21
|
L-5.5
|
U48.5
|
L-218
|
|
9/21/25
|
ARI
|
W 16-15
|
L-3.5
|
U47.5
|
W-180
|
|
9/14/25
|
@NO
|
W 26-21
|
L-7.0
|
O44.5
|
W-340
|
|
9/07/25
|
@SEA
|
W 17-13
|
W-1.5
|
U45.5
|
W-124
|
|
1/05/25
|
@ARI
|
L 47-24
|
L-5.5
|
O43
|
L-230
|
|
12/30/24
|
DET
|
L 40-34
|
L-4.5
|
O49.5
|
L-205
|
|
12/22/24
|
@MIA
|
L 29-17
|
L-1.0
|
U49
|
L-115
|
|
12/12/24
|
LAR
|
L 12-6
|
L-7.0
|
U47.5
|
L-335
|
|
12/08/24
|
CHI
|
W 38-13
|
W-5.5
|
O47.5
|
W-230
|
|
12/01/24
|
@BUF
|
L 35-10
|
L-2.0
|
U47
|
L-125
|
49ers vs Rams Betting Prediction: San Francisco Offense
Overall
| SF Offense | Off. Rank | Stat | Def. Rank | LAR Defense |
|---|---|---|---|---|
| 20.00 | 23 | Points Scored | 10 | 20.25 |
| 280.00 | 2 | Passing Yards | 10 | 186.00 |
| 88.00 | 28 | Rushing Yards | 10 | 98.50 |
| 30:23 | 17 | Time on Field | 19 | 30:05 |
| 66.25 | 4 | Number of Plays | 14 | 60.00 |
| 5.55 | 13 | Yards Per Play | 10 | 4.74 |
Scoring
| SF Offense | Off. Rank | Stat | Def. Rank | LAR Defense |
|---|---|---|---|---|
| 20.00 | 23 | Points Scored | 10 | 20.25 |
| 4.00 | 22 | First Quarter | 9 | 3.25 |
| 4.75 | 26 | Second Quarter | 15 | 6.50 |
| 2.75 | 30 | Third Quarter | 14 | 4.25 |
| 8.50 | 11 | Fourth Quarter | 13 | 6.25 |
Passing
| SF Offense | Off. Rank | Stat | Def. Rank | LAR Defense |
|---|---|---|---|---|
| 280.00 | 2 | Passing Yards | 10 | 186.00 |
| 38.25 | 3 | Pass Attempts | 14 | 31.25 |
| 25.25 | 2 | Pass Completions | 16 | 20.75 |
| 1.50 | 8 | Sacks | 3 | 3.50 |
| 7.25 | 29 | Sack Yards | 31 | 26.75 |
| 11.09 | 5 | Yards Per Pass | 7 | 8.96 |
Rushing
| SF Offense | Off. Rank | Stat | Def. Rank | LAR Defense |
|---|---|---|---|---|
| 88.00 | 28 | Rushing Yards | 10 | 98.50 |
| 26.50 | 16 | Rush Attempts | 11 | 25.25 |
| 3.32 | 31 | Yards Per Rush | 9 | 3.90 |
Turn Overs
| SF Offense | Off. Rank | Stat | Def. Rank | LAR Defense |
|---|---|---|---|---|
| 1.25 | 30 | Interceptions | 12 | 0.75 |
| 1.50 | 29 | Fumbles | 11 | 1.25 |
| 0.75 | 28 | Fumbles Lost | 4 | 1.00 |
| 2.00 | 32 | Total Turnovers | 4 | 1.75 |
| 6.00 | 8 | Penalties | 3 | 9.25 |
| 56.00 | 15 | Penalty Yards | 6 | 70.00 |
Drives & Special Teams
| SF Offense | Off. Rank | Stat | Def. Rank | LAR Defense |
|---|---|---|---|---|
| 30:23 | 17 | Time on Field | 19 | 30:05 |
| 66.25 | 4 | Number of Plays | 14 | 60.00 |
| 5.55 | 13 | Yards Per Play | 10 | 4.74 |
| 2.75 | 6 | Punts | 11 | 4.25 |
| 44.39 | 28 | Punt Average | 31 | 52.31 |
| 82.25 | 31 | Return Yards | 1 | 82.00 |
49ers vs Rams Betting Prediction: Los Angeles
The Rams, on the other hand, have been one of the league’s most efficient and balanced teams through the first month of the season. They have covered six of their last seven spreads and come into this matchup with a strong passing attack that ranks top three in the NFL. Quarterback play has been efficient, spreading the ball around effectively while also getting solid production on the ground. Defensively, Los Angeles is allowing just 20 points per game, a number that matches up well against the 49ers’ inconsistent offense. With their ability to win both through the air and on the ground, the Rams have the kind of balance that gives them an advantage in this divisional showdown.
49ers vs Rams Betting Prediction: Los Angeles Trends
- After seven games, the Los Angeles Rams have a record of 6-1 against the spread.
- The Los Angeles Rams have a winning record of 9-3 in their previous 12 games.
- Four of the last five games that the Los Angeles Rams have played versus San Francisco have resulted in the total going over.
- Over the past six games played at home, the Los Angeles Rams have a record of 5-1 against the spread.
- When playing at home against San Francisco, the total has gone over in four of the last five games that the Los Angeles Rams have played.
- When playing against teams from the National Football Conference, the Los Angeles Rams have a record of 5-2 against the spread in their last seven games.
- The Los Angeles Rams have a winning record of 8-2 in their previous ten games against teams that are members of the National Football Conference West division.
- In five of the last seven games that the Los Angeles Rams have played in the month of October, the total has been under.
- The Los Angeles Rams have a winning percentage of 3-8 in their previous 11 games played in week 5.
Los Angeles Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
9/28/25
|
IND
|
W 27-20
|
W-6.5
|
O46.5
|
W-285
|
|
9/21/25
|
@PHI
|
L 33-26
|
L+4.5
|
O46.5
|
L+170
|
|
9/14/25
|
@TEN
|
W 33-19
|
W-4.5
|
O45.5
|
W-205
|
|
9/07/25
|
HOU
|
W 14-9
|
W-2.5
|
U46.5
|
W-146
|
|
1/19/25
|
@PHI
|
L 28-22
|
L+5.5
|
O44.5
|
L+198
|
|
1/13/25
|
MIN
|
W 27-9
|
W+2.5
|
U47.5
|
W+110
|
|
1/05/25
|
SEA
|
L 30-25
|
L-5.5
|
O47
|
L-225
|
|
12/28/24
|
ARI
|
W 13-9
|
L-5.5
|
U48.5
|
W-238
|
|
12/22/24
|
@NYJ
|
W 19-9
|
W+3.0
|
U47.5
|
W+130
|
|
12/12/24
|
@SF
|
W 12-6
|
W+7.0
|
U47.5
|
W+260
|
49ers vs Rams Betting Prediction: Los Angeles Offense
Overall
| SF Defense | Def. Rank | Stat | Off. Rank | LAR Offense |
|---|---|---|---|---|
| 18.75 | 7 | Points Scored | 13 | 25.00 |
| 165.00 | 6 | Passing Yards | 3 | 267.50 |
| 115.50 | 17 | Rushing Yards | 13 | 120.75 |
| 29:36 | 14 | Time on Field | 22 | 29:54 |
| 61.00 | 18 | Number of Plays | 14 | 63.00 |
| 4.60 | 6 | Yards Per Play | 3 | 6.16 |
Scoring
| SF Defense | Def. Rank | Stat | Off. Rank | LAR Offense |
|---|---|---|---|---|
| 18.75 | 7 | Points Scored | 13 | 25.00 |
| 0.00 | 2 | First Quarter | 13 | 5.00 |
| 9.25 | 27 | Second Quarter | 15 | 7.25 |
| 4.75 | 17 | Third Quarter | 3 | 6.00 |
| 4.75 | 9 | Fourth Quarter | 15 | 6.75 |
Passing
| SF Defense | Def. Rank | Stat | Off. Rank | LAR Offense |
|---|---|---|---|---|
| 165.00 | 6 | Passing Yards | 3 | 267.50 |
| 30.75 | 12 | Pass Attempts | 11 | 34.25 |
| 21.00 | 19 | Pass Completions | 7 | 23.00 |
| 1.25 | 29 | Sacks | 14 | 2.00 |
| 7.50 | 5 | Sack Yards | 22 | 11.00 |
| 7.86 | 2 | Yards Per Pass | 3 | 11.63 |
Rushing
| SF Defense | Def. Rank | Stat | Off. Rank | LAR Offense |
|---|---|---|---|---|
| 115.50 | 17 | Rushing Yards | 13 | 120.75 |
| 29.00 | 23 | Rush Attempts | 15 | 26.75 |
| 3.98 | 10 | Yards Per Rush | 12 | 4.51 |
Turn Overs
| SF Defense | Def. Rank | Stat | Off. Rank | LAR Offense |
|---|---|---|---|---|
| 0.00 | 32 | Interceptions | 12 | 0.50 |
| 1.75 | 5 | Fumbles | 16 | 1.00 |
| 0.75 | 9 | Fumbles Lost | 23 | 0.50 |
| 0.75 | 25 | Total Turnovers | 16 | 1.00 |
| 7.00 | 18 | Penalties | 6 | 5.50 |
| 48.75 | 24 | Penalty Yards | 8 | 48.25 |
Drives & Special Teams
| SF Defense | Def. Rank | Stat | Off. Rank | LAR Offense |
|---|---|---|---|---|
| 29:36 | 14 | Time on Field | 22 | 29:54 |
| 61.00 | 18 | Number of Plays | 14 | 63.00 |
| 4.60 | 6 | Yards Per Play | 3 | 6.16 |
| 4.75 | 4 | Punts | 10 | 3.25 |
| 48.69 | 19 | Punt Average | 21 | 47.08 |
| 130.50 | 13 | Return Yards | 23 | 116.25 |
Our Pick: Los Angeles Rams ML and ATS ✅
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49ers vs Rams Betting Prediction, NFL Week 5, by YouWager.lv.