Jaguars vs 49ers Betting Prediction Week 4, 2025

Jaguars vs 49ers Betting Prediction Week 4, 2025

Jaguars vs 49ers Betting Prediction Week 4, 2025. Place a bet on this NFL football game with the best odds.

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The Week 4 clash between the Jacksonville Jaguars and San Francisco 49ers carries plenty of intrigue for bettors and fans alike.

Jaguars vs 49ers Betting Prediction

For bettors, this matchup presents a fascinating contrast. The Jaguars have shown improvement against the spread, covering in four of their last five games, but their dismal road record is difficult to ignore. San Francisco, while just 1-4 ATS at home recently, has a proven ability to win outright in these situations and has dominated the Jaguars historically. Total bettors should note that the UNDER has cashed consistently in head-to-head meetings, with six straight unders in this series. Ultimately, Jacksonville will need a near-flawless performance to keep pace with the 49ers’ passing attack, and unless they can establish the run early, San Francisco’s defense is likely to dictate the outcome. This looks like another opportunity for the Niners to flex their strength and continue their push as one of the NFC’s elite contenders.

Jaguars vs 49ers Betting Prediction: Head to Head

Date Team Opp Close Result ATS/OU
Nov 12, 2023 49ers @Jaguars -3 / 44.5 Won 34-3 Won / Under
Nov 21, 2021 49ers @Jaguars -6.5 / 45.5 Won 30-10 Won / Under
Dec 24, 2017 49ers Jaguars +4 / 43 Won 44-33 Won / Over
Oct 27, 2013 49ers Jaguars +16 / 40 Lost 0-0 Won / Under
Nov 29, 2009 49ers @Jaguars +3 / 42.5 Lost 0-0 Won / Under
Dec 18, 2005 49ers Jaguars -16 / 36.5 Lost 0-0 Lost / Under

Jaguars vs 49ers Betting Prediction: Jacksonville

Jacksonville enters the game with a balanced offense, averaging over 140 rushing yards and 214 passing yards per contest. Their ability to control possession and run efficient plays has allowed them to stay competitive even in tough matchups. However, the Jaguars’ biggest obstacle continues to be their struggles on the road. With just one win in their last thirteen road games, Jacksonville faces a major uphill climb traveling across the country to face one of the NFC’s most disciplined teams. Their defense has been reliable, holding opponents to just 17 points per game, but facing a quarterback and passing unit as sharp as San Francisco’s will test that consistency to the fullest.

Jaguars vs 49ers Betting Prediction: Jacksonville Trends

  • Over the past five games, Jacksonville has a record of 4-1 against the spread.
  • In six of Jacksonville’s most recent nine games, the total has been reported as UNDER.
  • Overall, Jacksonville has a record of 6-14 in its last 20 games.
  • The over/under record for Jacksonville’s last six games versus San Francisco is a 0-6 record.
  • The last five games that Jacksonville has played versus San Francisco have resulted in a losing record of 0-5 on the road.
  • Overall, Jacksonville has a record of 1-12 on the road in its last 13 games.
  • In Jacksonville’s last six games against teams from the National Football Conference, the Jaguars have a winning percentage of 1-5 against the opponent.
  • When it comes to the National Football Conference West division, Jacksonville has a record of 0-6 against the spread in its last six games versus opponents.
  • Five out of Jacksonville’s seven most recent games played in September have resulted in the total going UNDER.
  • After seven games played in week 4, Jacksonville has a record of 5-2 against the spread.

Jacksonville Last 10 Games

Date Opponent Score Spread Total Moneyline
9/21/25
W 17-10
W-1.5
U46.5
W-127
9/14/25
L 31-27
W+5.5
O49.5
L+198
9/07/25
W 26-10
W-2.5
U46.5
W-161
1/05/25
L 26-23
L+1.5
O46.5
L+102
12/29/24
W 20-13
W-4.0
U46
W-192
12/22/24
L 19-14
L-1.0
U45.5
L-115
12/15/24
L 32-25
L+1.0
O46
L-105
12/08/24
W 10-6
W-2.0
U45
W-125
12/01/24
L 23-20
L-1.0
U47
L-115
11/17/24
L 52-6
L+4.0
O50
L+160

Jaguars vs 49ers Betting Prediction: Jacksonville Offense

Overall

JAC Offense Off. Rank Stat Def. Rank SF Defense
23.33 14 Points Scored 3 16.33
214.67 13 Passing Yards 5 162.00
141.67 4 Rushing Yards 14 103.67
31:49 8 Time on Field 12 28:38
66.33 7 Number of Plays 15 60.33
5.37 13 Yards Per Play 5 4.40

Scoring

JAC Offense Off. Rank Stat Def. Rank SF Defense
23.33 14 Points Scored 3 16.33
5.67 11 First Quarter 2 0.00
9.00 8 Second Quarter 18 6.67
3.33 20 Third Quarter 15 3.33
5.33 26 Fourth Quarter 14 6.33

Passing

JAC Offense Off. Rank Stat Def. Rank SF Defense
214.67 13 Passing Yards 5 162.00
37.67 6 Pass Attempts 14 30.67
21.00 15 Pass Completions 16 21.00
1.00 3 Sacks 27 1.67
9.00 27 Sack Yards 8 10.00
10.22 13 Yards Per Pass 2 7.71

Rushing

JAC Offense Off. Rank Stat Def. Rank SF Defense
141.67 4 Rushing Yards 14 103.67
27.67 8 Rush Attempts 23 28.00
5.12 6 Yards Per Rush 7 3.70

Turn Overs

JAC Offense Off. Rank Stat Def. Rank SF Defense
1.33 29 Interceptions 31 0.00
0.33 6 Fumbles 3 2.00
0.00 6 Fumbles Lost 6 1.00
1.33 18 Total Turnovers 21 1.00
8.67 25 Penalties 28 5.33
72.67 29 Penalty Yards 30 35.00

Drives & Special Teams

JAC Offense Off. Rank Stat Def. Rank SF Defense
31:49 8 Time on Field 12 28:38
66.33 7 Number of Plays 15 60.33
5.37 13 Yards Per Play 5 4.40
3.33 12 Punts 7 4.67
49.88 8 Punt Average 23 49.16
101.00 26 Return Yards 7 108.00

Jaguars vs 49ers Betting Prediction: San Francisco

San Francisco is coming into this matchup with a perfect 3-0 start and a well-rounded identity that makes them one of the most difficult teams to prepare for. The 49ers’ passing game has been elite, averaging over 270 yards per outing and consistently moving the chains with efficiency. While their rushing attack has not been as strong, the Niners have made up for it with their ability to execute in late-game situations, posting an impressive nine points per fourth quarter on average. The defense has also been stout, limiting opponents to just 16.3 points per contest and under 4.5 yards per play. History favors San Francisco as well, as they have won five straight meetings against Jacksonville, including a 34-3 blowout in 2023.

Jaguars vs 49ers Betting Prediction: San Francisco Trends

  • The over/under record for San Francisco’s last 12 games is 3-9.
  • For San Francisco’s last six games, the total has been over in four of those games.
  • When San Francisco has played Jacksonville in the past seven games, the total has been UNDER in five of those games.
  • In its previous five games played at home, San Francisco has a record of 1-4 against the spread.
  • There have been five out of San Francisco’s last seven games against opponents in the American Football Conference that have resulted in the total going over.
  • San Francisco’s last five games against teams in the American Football Conference South division have all resulted with the total going UNDER in four of those games.
  • In its previous ten games played in September, San Francisco has a head-to-head record of 8-2.
  • After seven games played in week 4, San Francisco has a record of 5-2 against the spread.
  • In the last six games that San Francisco has played on a Sunday, the team has a winning record of 4-2 against the spread.

San Francisco Last 10 Games

Date Opponent Score Spread Total Moneyline
9/21/25
W 16-15
L-3.5
U47.5
W-180
9/14/25
W 26-21
L-7.0
O44.5
W-340
9/07/25
W 17-13
W-1.5
U45.5
W-124
1/05/25
L 47-24
L-5.5
O43
L-230
12/30/24
L 40-34
L-4.5
O49.5
L-205
12/22/24
L 29-17
L-1.0
U49
L-115
12/12/24
L 12-6
L-7.0
U47.5
L-335
12/08/24
W 38-13
W-5.5
O47.5
W-230
12/01/24
L 35-10
L-2.0
U47
L-125
11/24/24
L 38-10
L-2.5
O47
L-130

Jaguars vs 49ers Betting Prediction: San Francisco Offense

Overall

JAC Defense Def. Rank Stat Off. Rank SF Offense
17.00 7 Points Scored 23 19.67
209.33 16 Passing Yards 1 271.33
82.67 5 Rushing Yards 27 89.67
28:10 8 Time on Field 13 31:21
61.67 21 Number of Plays 4 67.33
4.74 8 Yards Per Play 14 5.36

Scoring

JAC Defense Def. Rank Stat Off. Rank SF Offense
17.00 7 Points Scored 23 19.67
3.33 9 First Quarter 21 4.33
2.00 2 Second Quarter 25 5.33
4.67 20 Third Quarter 30 1.00
7.00 19 Fourth Quarter 8 9.00

Passing

JAC Defense Def. Rank Stat Off. Rank SF Offense
209.33 16 Passing Yards 1 271.33
39.33 29 Pass Attempts 4 38.33
23.67 27 Pass Completions 5 26.33
2.00 21 Sacks 10 1.67
15.67 21 Sack Yards 28 8.67
8.85 9 Yards Per Pass 12 10.30

Rushing

JAC Defense Def. Rank Stat Off. Rank SF Offense
82.67 5 Rushing Yards 27 89.67
20.33 5 Rush Attempts 12 27.33
4.07 14 Yards Per Rush 28 3.28

Turn Overs

JAC Defense Def. Rank Stat Off. Rank SF Offense
2.33 1 Interceptions 26 1.00
0.67 19 Fumbles 22 1.00
0.67 8 Fumbles Lost 17 0.33
3.00 1 Total Turnovers 21 1.33
4.67 30 Penalties 13 6.33
43.33 27 Penalty Yards 12 56.67

Drives & Special Teams

JAC Defense Def. Rank Stat Off. Rank SF Offense
28:10 8 Time on Field 13 31:21
61.67 21 Number of Plays 4 67.33
4.74 8 Yards Per Play 14 5.36
3.67 17 Punts 11 3.00
46.63 10 Punt Average 27 44.14
95.33 5 Return Yards 30 77.67

 

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Jaguars vs 49ers Betting Prediction, NFL Week 18, by YouWager.lv.

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