Here are the NFL Week 1 Betting Odds and a preview for all the games from the first week of the upcoming regular season:

*All the YouWager NFL odds presented below are subject to change.

NFL Week 1 Betting Odds: Bills at Rams

Let’s start this NFL Week 1 Betting Odds article with the game between Buffalo and LA.

Both of these teams were great last season, and they are definitely going to be perceived as title contenders throughout the season.

And let’s not forget that LA is charged with defending their current title, so this is going to be interesting!

The Rams are 13-6-2 ATS and 18-3 SU in Week 1, and that can lead bettors to pick LA at home this time, especially because this is the second year with Matthew Stafford.

The odds for this game:

• Buffalo Bills PK -110
• LA Rams PK -110
• The total is set at 52 over/under

NFL Week 1 Betting Odds: Saints at Falcons

Now in this NFL Week 1 Betting Odds guide, the game between New Orleans and Atlanta.

The Saints are under a different regime after Sea Payton left, and it is now Dennis Allen who will be assuming as their new head coach.

And the great thing is that Jameis Winston after he lost a bulk of last season due to a torn ACL injury.

NOLA went 5-2 SU at the beginning of the season in 2021 with Jameis under center, outscoring rivals 176-128 over that particular stretch.

They will be opening the season versus Atlanta, a team that will be starting veteran Marcus Mariota as they traded QB Matt Ryan.

The odds for this game:

• New Orleans Saints -5
• Atlanta Falcons +5
• The total is set at 41.5 over/under

NFL Week 1 Betting Odds: Browns at Panthers

Next in this NFL Week 1 Betting Odds piece is the game between Cleveland and Carolina.

To analyze this one is difficult as Deshaun Watson it is still not clear if Deshaun Watson will start, or even play at all in the upcoming season.

One thing is for sure: Carolina is likely to start Baker Mayfield for this one, allowing the quarterback to face his former team right away.

With things like that, right now the Browns are one of the teams to be showing the most interest in Jimmy Garoppolo, the veteran Niners QB as San Francisco is looking to trade him.

The odds for this game:

• Cleveland Browns -1
• Carolina Panthers +1
• The total is set at 42 over/under

NFL Week 1 Betting Odds: 49ers at Bears

Let’s continue this NFL Week 1 Betting Odds guide with the game between San Fran and Chi-town.

The Niners have Trey Lance, who is ready to take as quarterback number one for San Francisco.

That is precisely why Garoppolo is likely to be on his way out of the team, with Cleveland having a good interest in the QB.

No matter who starts, the 49ers are favorites versus Chicago.

The Bears hired a new head coach, and they are in a rebuilding process, so this is likely to be another down year for the Wind City franchise.

The odds for this game:

• 49ers -6.5
• Bears +6.5
• The total is set at 42

NFL Week 1 Betting Odds: Steelers at Bengals

Next in this NFL Week 1 Betting Odds article is the game between Pittsburgh and Cincinnati.

The Bengals have a not-so-good history with week one games, going 2-6 ATS in the previous 8 seasons.

Cincinnati was able to fulfill most of its needs during the offseason, and that’s great.

But oddsmakers believe that the Steelers have what it takes to get their first win of the 2022-23 season in what is going to be the start of the post Big Ben era.

The odds for this game:

• Steelers -6
• Bengals +6
• The total is set at 44.5

NFL Week 1 Betting Odds: Eagles at Lions

Now we have the NFL Week 1 Betting Odds for the game between Philadelphia and Detroit.

If you placed any NFL bets last season, you know that Detroit was quite the generous team for bettors.

Yes, they finished with a 3-13-1 record, but they were 11-6 ATS, and they were a tough opponent.

During the offseason, they managed to add two great offensive weapons for Jared Goff in number two overall pick Aidan Hutchinson and number twelve overall Jameson Williams.

Now, the Lions have a better roster than last season, that is true, but Philly also added some depth as DeVonta Smith and AJ Brown are now Eagles.

The odds for this game:

• Eagles -4
• Lions +4
• The total is set at 46.5 over/under

NFL Week 1 Betting Odds: Colts at Texans

Let’s continue this NFL Week 1 Betting Odds guide with the game between Indianapolis and Houston.

The Colts are huge favorites in their opening game versus the Texans, and there is good reason for that.

They swapped Carson Wentz for veteran Matt Ryan, and that means that Indy is definitely better now in the quarterback department.

Ryan is likely to try to put up an excellent performance as will be trying to prove himself worthy of the starting Colts quarterback position.

And, with proficient weapons such as Michael Pittman and Jonathan Taylor, they definitely have the edge this time versus a still-rebuilding Houston club.

The odds for this game:

• Colts -8
• Texans +8
• The total is set at 44 over/under

NFL Week 1 Betting Odds: Patriots at Dolphins

Now in this NFL Week 1 Betting Odds article, the game between New England and Miami.

Miami became a stronger team during the offseason!

The Fins managed to surround Tua Tagovailoa with big names such as Chase Edmonds, Terron Armstead, Raheem Mostert, and Tyreek Hill. They are now part of a team that also counts on the services of Jaylen Waddle.

This is the second year for Mac Jones at the starting quarterback position for the Pats, and it is time for him to prove if he really has what it takes to get another title for New England.

In the defensive area, the Pats lost JC Jackson in free agency, and with a weaker defensive lineup, it will be difficult for the Patriots to defend against the speed of Waddle.

The odds for this game:

• Patriots +2.5
• Dolphins -2.5
• The total is set at 44.5 over/under

NFL Week 1 Betting Odds: Ravens at Jets

Now in our NFL Week 1 Betting Odds guide, the game between Baltimore and New York.

The Jets had an amazing offseason as they added a ton of talent, including 3 first-round picks.

That being said, they still are a team that is currently in rebuilding mode and not ready yet to be considered AFC contenders.

Baltimore has recovered from a forgettable 2021-22 season as they were plagued by injuries.

If the Ravens are able to keep a healthy roster, they can definitely be considered the dark horse in their conference.

Plus, they absolutely have a quarterback edge with Lamar Jackson over Zach Wilson.

The odds for this game:

• Ravens -6
• Jets +6
• The total is set at 45 over/under

NFL Week 1 Betting Odds: Jaguars at Commanders

Next in this NFL Week 1 Betting Odds article is the game between Jacksonville and Washington.

Urban Meyer was replaced by Doug Pederson during the offseason, and that seems to be a positive change for the Jags.

Trevor Lawrence is an outstanding quarterback that didn’t have a great first year in the NFL.

But his talent is there, and Jacksonville fans know that their team is in good hands when it comes to the starting QB position.

With Carson Wentz under center, Washington is a weak team.

Wentz committed 2 turnovers to the Jaguars last season in Week 18 as the starter for the Colts, and he is not expected to have a better overall performance this season.

The odds for this game:

• Jaguars +4
• Commanders -4
• The total is set at 44 over/under

Chiefs at Cardinals

Now in our NFL Week 1 Betting Odds guide, the game between Kansas City and Arizona.

The Cards have a good history of starting their season strong under head coach Kliff Kingsbury.

During his team as HC for Arizona, the team has managed to outscore rivals 89-60 during Week 1.

Yes, we are sure that the Chiefs are going to be contenders this upcoming season, but chances are that it will take some time for their offense to find its form as there are new pass-catchers on their roster.

It is also clear that not counting with DeAndre Hopkins due to suspension can be a key factor that can hurt the Cards, but chances are that they will find a way to cover the spread.

The odds for this game:

• Kansas City Chiefs -3
• Arizona Cardinals +3
• The total is set at 53 over/under

Raiders at Chargers

Let’s continue with this NFL Week 1 Betting Odds article with the game between Las Vegas and Los Angeles.

This is the game that is going to set the tone for the rest of the season for these two AFC West franchises.

This is a division where all the teams made great offseason moves and that means that they are all ready to battle for playoff positioning.

These two teams have excellent offensive weapons, including outstanding pass-rushing duos in Khalil Mack and Joey Bosa for LA and Maxx Crosby and Chandler Jones for Las Vegas.

The odds for this game:

• Las Vegas Raiders +3.5
• Los Angeles Chargers -3.5
• The total is set at 52 over/under

Packers at Vikings

It is now time in this NFL Week 1 Betting Odds guide to talking about Green Bay and Minnesota.

Aaron Rodgers had won five week-1 games in a row before last season when they fell to the Saints.

Rodgers is the current back-to-back NFL MVP, and he has always performed well during the first game of the regular season.

Rodgers is 10-4 SU in week one.

Kirk Cousins, on the other hand, has lost the last two week 1 game as the starter for Minnesota.

Now, it will be interesting how Rodgers is going to perform without Davante Adams as one of his favorite weapons, but chances are that will find a way to win.

The odds for this game:

• Green Bay Packers -2
• Minnesota Vikings +2
• The total is set at 49 over/under

Giants at Titans

Now in this NFL Week 1 Betting Odds article, let’s talk about the game between New York and Tennessee.

The Titans were one of the best teams when playing home games last season, covering 60% of their games.

Tennessee lost AJ Brown during the offseason, but Derrick Henry is still the top offensive man on the Titans’ roster.

If he is able to remain fully healthy, chances are that his team won’t have a problem defeating the Giants, a team that ranked 32nd in the league last season against the run.

The odds for this game:

• New York Giants +6.5
• Tennessee Titans -6.5
• The total is set at 44 over/under

Buccaneers at Cowboys

The next game in this NFL Week 1 Betting Odds guide is the one between Tampa Bay and Dallas.

This is a betting line that feels a bit off.

The Bucs were not a good road wager in 2021, going 3-6 ATS for the season.

The Cowboys were able to cover 5 of their 9 games at home last year.

Dallas was able to win at home for an average margin of twelve points, tied for the 2nd-most in the league.

Dallas counts with an outstanding defensive lineup that can give Tom Brady, the number one in our list of the Best 30 NFL Players Over 30, tons of trouble.

And the Cowboys also count on great offensive weapons to get the job done.

The odds for this game:

• Tampa Bay Buccaneers -2
• Dallas Cowboys +2
• The total is set at 52 over/under

Broncos at Seahawks

Last but not least in this NFL Week 1 Betting Odds article is the game between Denver and Seattle.

Russell Wilson is opening his season by facing his former team on the road.

Wilson put up a great show during his last game with the Seahawks in week 17 last season, finishing with 4 touchdowns.

Oddsmakers definitely believe Wilson is ready for a win at week one as Denver is road favorites for this game.

And that favoritism is probably linked to the fact that there is really no viable quarterback to combat Wilson on the other side of the fence.

The odds for this game:

• Denver Broncos -5
• Seattle Seahawks +5
• The total is set at 41.5 over/under

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