Saints vs Bills Betting Prediction Week 4, 2025
Saints vs Bills Betting Prediction Week 4, 2025. Place a bet on this NFL football game with the best odds.
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The Saints and Bills face off in a Week 4 matchup that offers bettors an intriguing contrast between a struggling New Orleans squad and a dominant Buffalo team.
Saints vs Bills Betting Prediction
When considering betting angles, the contrast couldn’t be sharper. The Saints have struggled to cover spreads and win on the road, while the Bills have been reliable both straight up and against the number, especially at home. Although New Orleans has historically had the edge over Buffalo, the current momentum strongly favors the Bills. With Buffalo’s high-powered offense going against a shaky Saints defense, the over/under line could be tested, though recent Saints trends lean heavily to the UNDER. For bettors, backing Buffalo to cover the spread while leaning toward the OVER on total points seems the most logical prediction, given how both teams have performed through the first month of the season.
Saints vs Bills Betting Prediction: Head to Head
| Date | Team | Opp | Close | Result | ATS/OU |
|---|---|---|---|---|---|
| Nov 25, 2021 | Bills | @Saints | -7 / 45 | Won 31-6 | Won / Under |
| Nov 12, 2017 | Bills | Saints | +2 / 48.5 | Lost 10-47 | Lost / Over |
| Oct 27, 2013 | Bills | Saints | -10.5 / 48 | Lost 0-0 | Lost / Under |
| Sep 27, 2009 | Bills | @Saints | -5.5 / 51.5 | Lost 0-0 | Lost / Under |
| Aug 10, 2007 | Bills | Saints | -6 / 36 | Lost 0-0 | Lost / Under |
| Oct 2, 2005 | Bills | Saints | -1.5 / 39 | Lost 0-0 | Lost / Under |
Saints vs Bills Betting Prediction: New Orleans
New Orleans has been unable to find rhythm this season, averaging just 17 points per game while ranking near the bottom of the league in yards per play. Their passing attack has been inefficient, generating only 197 yards per game and ranking 30th in yards per attempt. The rushing game has been a relative bright spot at 114 yards per game, but overall offensive production has been stagnant. Against the spread, the Saints are 0-7 in their last seven, raising concerns for bettors who might consider backing them despite their past success against Buffalo.
Saints vs Bills Betting Prediction: New Orleans Trends
- The over/under record for New Orleans’s last six games is 1-5.
- In six of New Orleans’ most recent nine games, the total has appeared to be UNDER.
- In its last seven games, New Orleans has a record of 0-7 against the spread.
- After six games versus Buffalo, New Orleans has a record of 5-1 against the spread.
- In its last six games versus Buffalo, New Orleans has a winning team record of 5-1.
- On the road, New Orleans has a record of 1-7 all-time in its last eight games.
- When New Orleans has played Buffalo away from home, the Saints have a winning record of 4-1 in their last five games.
- When New Orleans has played an opponent from the American Football Conference, the team has a record of 1-4 against the spread in its last five games.
- During the last five games that New Orleans has played against teams that are members of the American Football Conference East division, the total has been under in five of those games.
- After five games played in September, New Orleans has a record of 1-4 against the spread.
New Orleans Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
9/21/25
|
@SEA
|
L 44-13
|
L+6.5
|
O43.5
|
L+210
|
|
9/14/25
|
SF
|
L 26-21
|
W+7.0
|
O44.5
|
L+270
|
|
9/07/25
|
ARI
|
L 20-13
|
L+4.5
|
U41.5
|
L+168
|
|
1/05/25
|
@TB
|
L 27-19
|
L+2.5
|
O43
|
L+114
|
|
12/29/24
|
LV
|
L 25-10
|
L-2.0
|
U43
|
L-130
|
|
12/23/24
|
@GB
|
L 34-0
|
L+5.0
|
U45
|
L+180
|
|
12/15/24
|
WAS
|
L 20-19
|
L-2.5
|
U42
|
L-142
|
|
12/08/24
|
@NYG
|
W 14-11
|
W-0.5
|
U41
|
W-112
|
|
12/01/24
|
LAR
|
L 21-14
|
L+1.5
|
U46.5
|
L+102
|
|
11/17/24
|
CLE
|
W 35-14
|
W+2.0
|
O42
|
W+110
|
Saints vs Bills Betting Prediction: New Orleans Offense
Overall
| NO Offense | Off. Rank | Stat | Def. Rank | BUF Defense |
|---|---|---|---|---|
| 17.00 | 26 | Points Scored | 21 | 23.67 |
| 197.00 | 21 | Passing Yards | 1 | 131.33 |
| 114.00 | 14 | Rushing Yards | 30 | 156.00 |
| 27:44 | 24 | Time on Field | 3 | 25:01 |
| 68.00 | 7 | Number of Plays | 4 | 52.00 |
| 4.57 | 27 | Yards Per Play | 24 | 5.53 |
Scoring
| NO Offense | Off. Rank | Stat | Def. Rank | BUF Defense |
|---|---|---|---|---|
| 17.00 | 26 | Points Scored | 21 | 23.67 |
| 0.00 | 32 | First Quarter | 7 | 3.33 |
| 8.50 | 10 | Second Quarter | 22 | 9.00 |
| 3.50 | 16 | Third Quarter | 21 | 4.67 |
| 5.00 | 22 | Fourth Quarter | 16 | 6.67 |
Passing
| NO Offense | Off. Rank | Stat | Def. Rank | BUF Defense |
|---|---|---|---|---|
| 197.00 | 21 | Passing Yards | 1 | 131.33 |
| 40.00 | 4 | Pass Attempts | 2 | 25.00 |
| 26.00 | 5 | Pass Completions | 2 | 15.33 |
| 2.00 | 15 | Sacks | 16 | 2.00 |
| 13.50 | 18 | Sack Yards | 16 | 14.67 |
| 7.58 | 30 | Yards Per Pass | 8 | 8.57 |
Rushing
| NO Offense | Off. Rank | Stat | Def. Rank | BUF Defense |
|---|---|---|---|---|
| 114.00 | 14 | Rushing Yards | 30 | 156.00 |
| 26.00 | 14 | Rush Attempts | 12 | 25.00 |
| 4.38 | 16 | Yards Per Rush | 32 | 6.24 |
Turn Overs
| NO Offense | Off. Rank | Stat | Def. Rank | BUF Defense |
|---|---|---|---|---|
| 0.00 | 8 | Interceptions | 21 | 0.33 |
| 1.00 | 21 | Fumbles | 3 | 2.00 |
| 0.50 | 24 | Fumbles Lost | 7 | 0.67 |
| 0.50 | 15 | Total Turnovers | 13 | 1.00 |
| 10.00 | 29 | Penalties | 19 | 6.00 |
| 67.00 | 24 | Penalty Yards | 19 | 47.67 |
Drives & Special Teams
| NO Offense | Off. Rank | Stat | Def. Rank | BUF Defense |
|---|---|---|---|---|
| 27:44 | 24 | Time on Field | 3 | 25:01 |
| 68.00 | 7 | Number of Plays | 4 | 52.00 |
| 4.57 | 27 | Yards Per Play | 24 | 5.53 |
| 4.00 | 21 | Punts | 6 | 4.67 |
| 46.65 | 22 | Punt Average | 20 | 49.45 |
| 125.50 | 16 | Return Yards | 31 | 177.33 |
Saints vs Bills Betting Prediction: Buffalo
Buffalo, on the other hand, has been one of the league’s hottest teams, entering Week 4 with three straight wins and an average of 34 points per game. The Bills have dominated at home, winning 12 consecutive games in front of their fans, making Orchard Park one of the toughest venues in football. Their offense has been explosive and balanced, ranking seventh in passing and second in rushing while also leading the league in yards per pass. Defensively, Buffalo ranks first against the pass, holding opponents to just 131 yards per game, though their rushing defense remains vulnerable at 156 yards allowed. Bettors should note the Bills’ recent trend toward high-scoring games, hitting the OVER in four of their last five outings.
Saints vs Bills Betting Prediction: Buffalo Trends
- The over/under record for Buffalo’s last 18 games is 12-6.
- Out of Buffalo’s last five games, the total has been over in four of them.
- In its last six games, Buffalo has a winning record of 5-1 against the spread.
- There have been four of Buffalo’s last six games against New Orleans in which the total has been UNDER.
- At home, Buffalo has a perfect record of 12-0 in its last 12 games.
- During its last five home games versus New Orleans, Buffalo has a record of 1-4 on the road against the Saints.
- Overall, Buffalo has a record of 4-2 against the spread in its previous six games versus teams that are members of the National Football Conference.
- In its last 15 games played in September, Buffalo has a record of 10-5 against the line.
- In ten of Buffalo’s last twelve games played in week 4, the total has been under the projected amount.
- Ten of Buffalo’s last fourteen games that have been played on a Sunday have resulted in the total going over.
Buffalo Last 10 Games
| Date | Opponent | Score | Spread | Total | Moneyline |
|---|---|---|---|---|---|
|
9/18/25
|
MIA
|
W 31-21
|
W-8.5
|
O48.5
|
W-380
|
|
9/14/25
|
@NYJ
|
W 30-10
|
W-8.5
|
U44.5
|
W-380
|
|
9/07/25
|
BAL
|
W 41-40
|
L-1.5
|
O51.5
|
W-122
|
|
1/26/25
|
@KC
|
L 32-29
|
L+1.5
|
O48.5
|
L+102
|
|
1/19/25
|
BAL
|
W 27-25
|
W-1.0
|
O51.5
|
W-117
|
|
1/12/25
|
DEN
|
W 31-7
|
W-8.5
|
U47.5
|
W-440
|
|
1/05/25
|
@NE
|
L 23-16
|
L-3.5
|
U44.5
|
L-180
|
|
12/29/24
|
NYJ
|
W 40-14
|
W-2.5
|
O45.5
|
W-135
|
|
12/22/24
|
NE
|
W 24-21
|
L-7.5
|
O44.5
|
W-355
|
|
12/15/24
|
@DET
|
W 48-42
|
W+2.0
|
O50.5
|
W+114
|
Saints vs Bills Betting Prediction: Buffalo Offense
Overall
| NO Defense | Def. Rank | Stat | Off. Rank | BUF Offense |
|---|---|---|---|---|
| 23.00 | 18 | Points Scored | 2 | 34.00 |
| 198.50 | 14 | Passing Yards | 7 | 257.00 |
| 111.50 | 19 | Rushing Yards | 2 | 163.00 |
| 32:15 | 22 | Time on Field | 3 | 34:59 |
| 64.50 | 25 | Number of Plays | 5 | 68.67 |
| 4.81 | 9 | Yards Per Play | 5 | 6.12 |
Scoring
| NO Defense | Def. Rank | Stat | Off. Rank | BUF Offense |
|---|---|---|---|---|
| 23.00 | 18 | Points Scored | 2 | 34.00 |
| 4.50 | 17 | First Quarter | 4 | 8.00 |
| 12.00 | 31 | Second Quarter | 14 | 7.67 |
| 3.00 | 13 | Third Quarter | 6 | 5.33 |
| 3.50 | 8 | Fourth Quarter | 2 | 13.00 |
Passing
| NO Defense | Def. Rank | Stat | Off. Rank | BUF Offense |
|---|---|---|---|---|
| 198.50 | 14 | Passing Yards | 7 | 257.00 |
| 34.00 | 21 | Pass Attempts | 16 | 33.67 |
| 23.50 | 22 | Pass Completions | 11 | 23.33 |
| 4.00 | 4 | Sacks | 5 | 1.33 |
| 22.50 | 26 | Sack Yards | 30 | 5.33 |
| 8.45 | 7 | Yards Per Pass | 8 | 11.01 |
Rushing
| NO Defense | Def. Rank | Stat | Off. Rank | BUF Offense |
|---|---|---|---|---|
| 111.50 | 19 | Rushing Yards | 2 | 163.00 |
| 26.50 | 18 | Rush Attempts | 3 | 33.67 |
| 4.21 | 17 | Yards Per Rush | 9 | 4.84 |
Turn Overs
| NO Defense | Def. Rank | Stat | Off. Rank | BUF Offense |
|---|---|---|---|---|
| 0.00 | 29 | Interceptions | 3 | 0.00 |
| 1.00 | 16 | Fumbles | 23 | 1.33 |
| 0.50 | 15 | Fumbles Lost | 2 | 0.00 |
| 0.50 | 26 | Total Turnovers | 1 | 0.00 |
| 7.00 | 13 | Penalties | 3 | 4.67 |
| 47.00 | 21 | Penalty Yards | 10 | 47.33 |
Drives & Special Teams
| NO Defense | Def. Rank | Stat | Off. Rank | BUF Offense |
|---|---|---|---|---|
| 32:15 | 22 | Time on Field | 3 | 34:59 |
| 64.50 | 25 | Number of Plays | 5 | 68.67 |
| 4.81 | 9 | Yards Per Play | 5 | 6.12 |
| 4.00 | 14 | Punts | 8 | 3.00 |
| 45.15 | 7 | Punt Average | 30 | 42.54 |
| 75.50 | 3 | Return Yards | 13 | 132.00 |
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Saints vs Bills Betting Prediction, NFL Week 18, by YouWager.lv.