NFL Week 10 Betting Predictions, Picks & Odds | 15–16 Nov 2026
NFL Week 10 Betting Predictions, Picks & Odds | 15–16 Nov 2026
NFL Week 10 Betting Predictions: see all 13 Sunday and Monday winner picks, fixed odds, and links to the full matchup previews.
Our NFL Week 10 Betting Predictions cover the 13 games on Sunday and Monday. Start with the winner picks and odds below, then open the full preview for the case behind each call. Check YouWager for available markets.
Week 10 picks and odds at a glance
| Matchup | Prediction | Spread | Total | Moneyline | WAGER NOW |
|---|---|---|---|---|---|
| New England Patriots vs Detroit Lions | Detroit Lions to win | New England Patriots: +2.5 (+100) / Detroit Lions: -2.5 (-120) | New England Patriots: Over 50.5 (-102) / Detroit Lions: Under 50.5 (-118) | New England Patriots: +124 / Detroit Lions: -148 | WAGER NOW |
| Kansas City Chiefs vs Atlanta Falcons | Kansas City Chiefs to win | Kansas City Chiefs: -3 (-120) / Atlanta Falcons: +3 (+100) | Kansas City Chiefs: Over 46.5 (-110) / Atlanta Falcons: Under 46.5 (-110) | Kansas City Chiefs: -180 / Atlanta Falcons: +150 | WAGER NOW |
| Houston Texans vs Cleveland Browns | Houston Texans to win | Houston Texans: -4.5 (-110) / Cleveland Browns: +4.5 (-110) | Houston Texans: Over 40.5 (-108) / Cleveland Browns: Under 40.5 (-112) | Houston Texans: -225 / Cleveland Browns: +185 | WAGER NOW |
| Minnesota Vikings vs Green Bay Packers | Green Bay Packers to win | Minnesota Vikings: +3 (-115) / Green Bay Packers: -3 (-105) | Minnesota Vikings: Over 41.5 (-115) / Green Bay Packers: Under 41.5 (N/A) | Minnesota Vikings: +124 / Green Bay Packers: -148 | WAGER NOW |
| Jacksonville Jaguars vs Tennessee Titans | Jacksonville Jaguars to win | Jacksonville Jaguars: -10.5 (-112) / Tennessee Titans: +10.5 (-108) | Jacksonville Jaguars: Over 46.5 (-110) / Tennessee Titans: Under 46.5 (-110) | Jacksonville Jaguars: -600 / Tennessee Titans: +440 | WAGER NOW |
| Miami Dolphins vs Indianapolis Colts | Indianapolis Colts to win | Miami Dolphins: +3.5 (-102) / Indianapolis Colts: -3.5 (-118) | Miami Dolphins: Over 38.5 (-105) / Indianapolis Colts: Under 38.5 (-115) | Miami Dolphins: +164 / Indianapolis Colts: -198 | WAGER NOW |
| Carolina Panthers vs New Orleans Saints | New Orleans Saints to win | Carolina Panthers: +2.5 (-112) / New Orleans Saints: -2.5 (-108) | Carolina Panthers: Over 48.5 (-112) / New Orleans Saints: Under 48.5 (-108) | Carolina Panthers: +114 / New Orleans Saints: -135 | WAGER NOW |
| Buffalo Bills vs New York Jets | Buffalo Bills to win | Buffalo Bills: -8.5 (-108) / New York Jets: +8.5 (-112) | Buffalo Bills: Over 50.5 (-118) / New York Jets: Under 50.5 (-102) | Buffalo Bills: -440 / New York Jets: +340 | WAGER NOW |
| Seattle Seahawks vs Las Vegas Raiders | Seattle Seahawks to win | Seattle Seahawks: -6.5 (-112) / Las Vegas Raiders: +6.5 (-108) | Seattle Seahawks: Over 40.5 (-112) / Las Vegas Raiders: Under 40.5 (-108) | Seattle Seahawks: -298 / Las Vegas Raiders: +240 | WAGER NOW |
| Los Angeles Rams vs Arizona Cardinals | Los Angeles Rams to win | Los Angeles Rams: -9.5 (-112) / Arizona Cardinals: +9.5 (-108) | Los Angeles Rams: Over 39.5 (-108) / Arizona Cardinals: Under 39.5 (-112) | Los Angeles Rams: -485 / Arizona Cardinals: +370 | WAGER NOW |
| San Francisco 49ers vs Dallas Cowboys | San Francisco 49ers to win | San Francisco 49ers: -3.5 (-115) / Dallas Cowboys: +3.5 (-105) | San Francisco 49ers: Over 55.5 (-118) / Dallas Cowboys: Under 55.5 (-102) | San Francisco 49ers: -205 / Dallas Cowboys: +170 | WAGER NOW |
| Pittsburgh Steelers vs Cincinnati Bengals | Cincinnati Bengals to win | Pittsburgh Steelers: +3.5 (-110) / Cincinnati Bengals: -3.5 (-110) | Pittsburgh Steelers: Over 49.5 (-108) / Cincinnati Bengals: Under 49.5 (-112) | Pittsburgh Steelers: +150 / Cincinnati Bengals: -180 | WAGER NOW |
| Los Angeles Chargers vs Baltimore Ravens | Los Angeles Chargers to win | Los Angeles Chargers: +4.5 (-112) / Baltimore Ravens: -4.5 (-108) | Los Angeles Chargers: Over 38.5 (-110) / Baltimore Ravens: Under 38.5 (-110) | Los Angeles Chargers: +190 / Baltimore Ravens: -230 | WAGER NOW |
These NFL Week 10 Betting Predictions are straight-up winner calls. The odds are snapshots from the game previews; N/A means a figure was unavailable. The matchup pick can stay the same even when the price changes. For background, see the NFL overview and this study of sports outcomes.
New England Patriots vs Detroit Lions
Detroit Lions to win. In Munich, New England needs to keep the first two downs manageable so Detroit cannot dictate the game with its pass rush. Detroit can take control by turning early runs and short throws into a series of playable third downs. The neutral setting takes away the normal home-field assumption. Watch what happens after a negative play. If Detroit Lions can regain enough yardage on the next snap, the offense can keep its full playbook open.
New England Patriots vs Detroit Lions Betting Prediction, Picks & Odds | 15 Nov 2026
Kansas City Chiefs vs Atlanta Falcons
Kansas City Chiefs to win. Kansas City can put Atlanta in a bind by making its second-level defenders choose between an underneath target and help against the run. Atlanta can respond by getting pressure with its front and avoiding a scramble when Kansas City extends a play. Watch what happens after a negative play. If Kansas City Chiefs can regain enough yardage on the next snap, the offense can keep its full playbook open.
Kansas City Chiefs vs Atlanta Falcons Betting Prediction, Picks & Odds | 15 Nov 2026
Houston Texans vs Cleveland Browns
Houston Texans to win. Houston needs to keep Cleveland from turning early-down losses into obvious passing situations. Cleveland can narrow the gap by making Houston drive the length of the field rather than giving away short fields with penalties or turnovers. Watch what happens after a negative play. If Houston Texans can regain enough yardage on the next snap, the offense can keep its full playbook open. If Cleveland Browns keeps creating obvious passing downs, the rush can attack without giving the run the same attention.
Houston Texans vs Cleveland Browns Betting Prediction, Picks & Odds | 15 Nov 2026
Minnesota Vikings vs Green Bay Packers
Green Bay Packers to win. Minnesota can keep Green Bay from controlling the pace if it tackles short catches cleanly and makes the Packers convert a second tough down. Green Bay can counter with quick throws that force Minnesota’s underneath defenders to cover the width of the field before testing them deeper. Watch what happens after a negative play. If Green Bay Packers can regain enough yardage on the next snap, the offense can keep its full playbook open.
Minnesota Vikings vs Green Bay Packers Betting Prediction, Picks & Odds | 15 Nov 2026
Jacksonville Jaguars vs Tennessee Titans
Jacksonville Jaguars to win. Jacksonville can make Tennessee chase the game by staying ahead of the chains on early downs. The Titans can keep it tight if they get stops without exposing the back end and turn those stops into sustained drives rather than quick punts. Watch what happens after a negative play. If Jacksonville Jaguars can regain enough yardage on the next snap, the offense can keep its full playbook open. That can change both the drive and where the next offense gets the ball.
Jacksonville Jaguars vs Tennessee Titans Betting Prediction, Picks & Odds | 15 Nov 2026
Miami Dolphins vs Indianapolis Colts
Indianapolis Colts to win. Miami needs the ball out before Indianapolis can squeeze the space around the pocket. Indianapolis can take away that rhythm by tackling the short throws and making the Dolphins show they can finish a drive after a penalty or negative play. Watch what happens after a negative play. If Indianapolis Colts can regain enough yardage on the next snap, the offense can keep its full playbook open. That can change both the drive and where the next offense gets the ball.
Miami Dolphins vs Indianapolis Colts Betting Prediction, Picks & Odds | 15 Nov 2026
Carolina Panthers vs New Orleans Saints
New Orleans Saints to win. Carolina’s route is to create manageable third downs instead of counting on one long gain to rescue each drive. New Orleans can take over if it wins those early snaps and keeps the Panthers from turning a first-down run into a favorable second down. Watch what happens after a negative play. If New Orleans Saints can regain enough yardage on the next snap, the offense can keep its full playbook open.
Carolina Panthers vs New Orleans Saints Betting Prediction, Picks & Odds | 15 Nov 2026
Before the late games, check the current numbers at YouWager. The full previews explain the main matchup risk behind each selection.
Buffalo Bills vs New York Jets
Buffalo Bills to win. Buffalo can keep the Jets from setting the terms by moving the chains without leaning on throws late in the down. The Jets can make it more competitive by keeping the ball in front, finishing tackles, and making Buffalo earn points inside the 20. Watch what happens after a negative play. If Buffalo Bills can regain enough yardage on the next snap, the offense can keep its full playbook open.
Buffalo Bills vs New York Jets Betting Prediction, Picks & Odds | 15 Nov 2026
Seattle Seahawks vs Las Vegas Raiders
Seattle Seahawks to win. Seattle can give itself room if it makes the Raiders cover underneath without getting a free shot at the ball. Las Vegas can keep this close by holding up on first down and putting Seattle in spots where it has to show its protection before the snap. Watch what happens after a negative play. If Seattle Seahawks can regain enough yardage on the next snap, the offense can keep its full playbook open.
Seattle Seahawks vs Las Vegas Raiders Betting Prediction, Picks & Odds | 15 Nov 2026
Los Angeles Rams vs Arizona Cardinals
Los Angeles Rams to win. The Rams can force Arizona to defend both directions if they get a clean release off play action after establishing a credible run look. Arizona can stop that from snowballing by keeping the edge contained and making the Rams take shorter completions that end in bounds. Watch what happens after a negative play. If Los Angeles Rams can regain enough yardage on the next snap, the offense can keep its full playbook open.
Los Angeles Rams vs Arizona Cardinals Betting Prediction, Picks & Odds | 15 Nov 2026
San Francisco 49ers vs Dallas Cowboys
San Francisco 49ers to win. San Francisco can pull Dallas out of position by forcing defenders to account for motion before the snap and the run fit after it. Dallas can push back by staying disciplined on the edges and making the 49ers prove they can win from long yardage. Watch what happens after a negative play. If San Francisco 49ers can regain enough yardage on the next snap, the offense can keep its full playbook open.
San Francisco 49ers vs Dallas Cowboys Betting Prediction, Picks & Odds | 15 Nov 2026
Pittsburgh Steelers vs Cincinnati Bengals
Cincinnati Bengals to win. Pittsburgh can limit Cincinnati’s bigger gains by keeping the pocket from staying clean on third down. Cincinnati can blunt the pressure by throwing on schedule and avoiding the early-down losses that let Pittsburgh attack without respecting the run. Watch what happens after a negative play. If Cincinnati Bengals can regain enough yardage on the next snap, the offense can keep its full playbook open. If Pittsburgh Steelers keeps creating obvious passing downs, the rush can attack without giving the run the same attention.
Pittsburgh Steelers vs Cincinnati Bengals Betting Prediction, Picks & Odds | 15 Nov 2026
Los Angeles Chargers vs Baltimore Ravens
Los Angeles Chargers to win. The Chargers need to keep Baltimore from getting extra possessions through short fields or quick punts. Baltimore can put the game on its terms by making Los Angeles defend the run without losing track of the next passing window. Watch what happens after a negative play. If Los Angeles Chargers can regain enough yardage on the next snap, the offense can keep its full playbook open. That can change both the drive and where the next offense gets the ball.
Los Angeles Chargers vs Baltimore Ravens Betting Prediction, Picks & Odds | 16 Nov 2026
Final look before kickoff
Start with the winner call, then check the market and final availability. The number you can get matters as much as the team you like. See the available NFL markets at YouWager.