Colts vs Patriots Preseason NFL Prediction: Who Will Win the Colts vs Patriots Game on August 13, 2026?

Colts vs Patriots Preseason NFL Prediction: Who will win Colts vs Patriots? Get the latest preseason odds, picks, over/under, player news, and best bets.

Colts vs Patriots Preseason NFL Prediction: Who Will Win the Colts vs Patriots Game Today?

The best bet for the Colts vs Patriots Preseason NFL Prediction is the Over 40.5 total points. New England has a slight advantage as the reigning AFC champion and the home team, but uncertainty surrounding quarterback playing time makes the game winner difficult to predict. The stronger betting angle is the total, with both teams expected to use the game to evaluate players competing for roster spots.

Best Bet: Over 40.5 Points

Projected Score: Patriots 24, Colts 20

Colts vs Patriots Preseason NFL Prediction Summary

The Indianapolis Colts and New England Patriots meet Thursday in Foxborough for the opening preseason game for both teams. The biggest question entering the matchup is whether either starting quarterback will see action.

New England enters as the slight favorite, which is understandable considering the Patriots are the reigning AFC Conference champions and have home-field advantage. However, the Patriots’ price is not particularly attractive if Drake Maye is limited or does not play.

Preseason games are primarily about roster evaluation. Both teams must eventually reduce their rosters from 90 players to 53, making playing time for bubble players one of the biggest storylines.

The uncertainty surrounding the starting quarterbacks makes the Colts vs Patriots Preseason NFL Prediction difficult from a moneyline perspective. The total offers a more attractive opportunity because preseason backups can still produce points, as demonstrated by the recent Pro Football Hall of Fame Game between Carolina and Arizona.

The preferred picks are Over 40.5 total points and Over 10.5 points in the first quarter.

Colts vs Patriots Odds
Colts vs Patriots Same Game Parlay
Colts vs Patriots Player Props
Who will win Colts vs Patriots?
Who is favored in Colts vs Patriots?
What is the best bet for Colts vs Patriots?
Will Drake Maye play?
What are the key factors for Colts vs Patriots?
Final Colts vs Patriots Preseason NFL Prediction
Colts vs Patriots FAQ

Colts vs Patriots Odds

The New England Patriots enter the Colts vs Patriots matchup as a slight favorite at home.

The market is particularly sensitive to the status of Drake Maye. If Maye is ruled out or expected to play only a very limited number of snaps, New England’s price could move significantly.

The Patriots are currently around the mid-50-cent range in the winner market, while Indianapolis is around the mid-40-cent range. Those prices indicate a relatively even matchup rather than a major advantage for New England.

Market	Indianapolis Colts	New England Patriots
Winner Market	Around 46¢	Around 54¢
Game Total	Over 40.5	Under 40.5
First Quarter Total	Over 10.5	Under 10.5
Location	Foxborough	Foxborough
Game	Preseason	Preseason

What is the point spread in NFL betting? The point spread gives the underdog a points advantage while requiring the favorite to win by more than the listed number for the favorite’s bet to cash.

The important distinction here is that these are preseason markets, where quarterback availability and roster rotations can have a much larger impact than they would during the regular season.

Colts vs Patriots Same Game Parlay

A Colts vs Patriots same game parlay should focus on markets that account for the unusual nature of preseason football.

The Over 40.5 is the strongest angle because neither team’s backups should automatically be expected to produce a low-scoring game. Preseason offenses frequently benefit from defensive mistakes, inexperienced players and extended opportunities for quarterbacks and skill-position players trying to make the roster.

The first-quarter Over 10.5 is another interesting option. If either starting quarterback plays, or if both teams script their opening possessions aggressively, the game could get off to a fast start.

The primary concern with any Colts vs Patriots same game parlay is playing time. A quarterback being unexpectedly held out can change the value of several correlated markets.

Colts vs Patriots Player Props

Colts vs Patriots player props are difficult to evaluate before the teams announce their preseason rotations.

Drake Maye is the most important player to monitor. If New England’s starting quarterback plays, he could receive a couple of drives before the Patriots turn the offense over to their backups.

The same uncertainty applies to Indianapolis. If the Colts rest their starting quarterback, backup players will receive more opportunities to accumulate passing, rushing and receiving statistics.

For that reason, player props should be evaluated after official inactives and expected snap counts become available.

The biggest opportunity may come from backup running backs and receivers who are competing for roster spots. These players could receive significantly more snaps than they would during a regular-season game.

Colts vs Patriots, Who Will Win Today?

The New England Patriots are the slight favorite to beat the Indianapolis Colts.

New England has the benefit of playing at home and enters the preseason as the reigning AFC Conference champion. Those factors make the Patriots the logical side in the winner market.

However, the Colts vs Patriots Preseason NFL Prediction is not strong enough to justify paying an inflated price on New England.

The status of Drake Maye is particularly important. If Maye plays for only a couple of drives, the Patriots will spend most of the game relying on their backup quarterbacks.

Indianapolis therefore has a realistic chance to win outright, particularly if the Colts’ primary offensive players receive more playing time.

Projected Winner: Patriots

Projected Score: Patriots 24, Colts 20

Who Is Favored in Colts vs Patriots?

The New England Patriots are favored over the Indianapolis Colts in Thursday’s preseason matchup.

The Patriots’ home-field advantage and status as the reigning AFC Conference champions explain the slight edge.

However, the favorite’s price is not particularly appealing if Drake Maye does not play. A preseason favorite can still win without its starting quarterback, but the probability of winning decreases when the team’s most important offensive player is unavailable.

The Colts become more attractive if New England confirms that Maye will sit.

For that reason, the moneyline should be monitored closely before kickoff.

What Is the Best Bet for Colts vs Patriots?

The best bet for the Colts vs Patriots Preseason NFL Prediction is Over 40.5 total points.

The uncertainty surrounding quarterback participation makes the winner market less appealing. The total provides a different way to attack the game.

The lack of established starters does not necessarily mean that the game will be low-scoring. Preseason defenses are filled with inexperienced players, while backup quarterbacks and young skill-position players are fighting for roster spots.

Those circumstances can lead to explosive plays and defensive mistakes.

The recent Pro Football Hall of Fame Game between the Panthers and Cardinals also demonstrated that preseason football can produce more scoring than bettors expect.

Best Bet: Over 40.5 Points

Secondary Pick: First Quarter Over 10.5 Points

Will Drake Maye Play Against the Colts?

Whether Drake Maye plays against the Colts is one of the most important questions surrounding this preseason matchup.

The Patriots have not provided enough certainty to assume that Maye will play a normal workload. If he does appear, the expectation is that his participation will be limited to a couple of drives.

That is standard preseason management for an established starting quarterback.

The joint practice between the Colts and Patriots is also relevant. The teams are using the practice session in Foxborough to evaluate players and work through specific situations before Thursday night’s game.

If Maye receives meaningful work during the joint practice, that could provide an indication of how much action he is likely to see in the preseason opener.

What Are the Key Factors for Colts vs Patriots?

The biggest factor in the Colts vs Patriots Preseason NFL Prediction is quarterback playing time.

Both teams have 90-player rosters that eventually must be reduced to 53 players. That means Thursday’s game is an important evaluation opportunity for players on the roster bubble.

The joint practice is also significant because coaches can evaluate players in controlled situations without the pressure of an official game.

Other important factors include:

Drake Maye’s availability and expected workload.
Indianapolis’ starting quarterback plans.
Which backup quarterback receives the most snaps.
The performance of second-team offensive lines.
Young receivers and running backs competing for roster spots.
Defensive depth and missed assignments.
First-quarter offensive game plans.
How aggressively each coaching staff approaches the preseason opener.

These variables make preseason football fundamentally different from regular-season betting.

Final Colts vs Patriots Preseason NFL Prediction

The Colts vs Patriots Preseason NFL Prediction is a difficult moneyline call because the quarterback rotations remain uncertain.

New England has the obvious advantages. The Patriots are playing at home and enter the preseason as the reigning AFC Conference champions. If Drake Maye plays, even for a couple of drives, New England could have an early offensive advantage.

But the Patriots’ winner-market price does not offer enough value to make them the preferred wager.

The total is more attractive.

The Over 40.5 gives bettors an opportunity to take advantage of the unpredictability of preseason football. Backup quarterbacks can generate points, inexperienced defenses can surrender explosive plays, and players fighting for roster spots have every incentive to play aggressively.

The first-quarter Over 10.5 is also appealing if either team’s starting offense receives meaningful playing time.

The best overall approach is therefore to avoid overpaying for the Patriots and instead target the scoring markets.

Final Picks: Over 40.5 Points and First Quarter Over 10.5

Projected Score: Patriots 24, Colts 20

Best Bet: Over 40.5 Points

Secondary Bet: First Quarter Over 10.5 Points

Colts vs Patriots FAQ

Who is favored in Colts vs Patriots?

The New England Patriots are the slight favorite against the Indianapolis Colts.

What is the best bet for Colts vs Patriots?

The best bet is Over 40.5 total points, with the First Quarter Over 10.5 as a secondary pick.

Will Drake Maye play against the Colts?

Maye’s status is uncertain, but if he plays, he is expected to see only a couple of drives.

Where is Colts vs Patriots being played?

The game will be played in Foxborough, Massachusetts, at the Patriots’ home stadium.

When is Colts vs Patriots?

Colts vs Patriots is scheduled for Thursday, August 13, 2026.

Is Colts vs Patriots a regular-season game?

No. Colts vs Patriots is a preseason NFL matchup and marks the beginning of the preseason for both teams.

Why is Colts vs Patriots important?

The game gives both teams an opportunity to evaluate players competing for roster spots before NFL rosters are reduced from 90 players to 53.

Can the Colts beat the Patriots?

Yes. Indianapolis has a realistic chance to win outright, particularly if New England limits Drake Maye and its other key starters.

What is the Colts vs Patriots over/under?

The recommended total is Over 40.5 points.

What is the Colts vs Patriots first-quarter pick?

The preferred first-quarter wager is Over 10.5 points.

What is the final Colts vs Patriots preseason prediction?

The final Colts vs Patriots Preseason NFL Prediction is Over 40.5 points, with a projected score of Patriots 24, Colts 20.

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Colts vs Patriots Preseason NFL Prediction: Who Will Win the Colts vs Patriots Game on August 13, 2026?