Saints vs Panthers Prediction and Pick, Week 10

The Saints and Panthers meet again in Week 10, and while both teams have shown drastically different stretches of performance this season, the familiarity and divisional stakes always make this matchup worth a closer look. The recent head-to-head history between these two has swung back and forth, including some blowout wins from New Orleans and a dramatic one-point Panthers win earlier this season. That shows just how unpredictable this rivalry can be depending on quarterback play, defensive execution, and which team establishes tempo. The Saints have seen their offense struggle to find rhythm, ranking near the bottom of the league in scoring and efficiency, while Carolina has shown signs of life behind improved offensive line play and a renewed emphasis on the run game. However, both defenses have had major inconsistencies as well, making this a matchup where field position, turnovers, and red-zone efficiency could dictate the result more than raw yardage. When these NFC South teams face off, the game rarely follows the script — meaning the deciding factor could simply be which group plays cleaner football for four full quarters.

For the Saints, the offense continues to be the biggest concern. They sit near the bottom of the league in total scoring and are struggling to establish any balance or momentum. The passing game has not generated enough explosive plays, with yards per pass ranked among the worst in the NFL. The run game has been similarly inconsistent, managing just 3.83 yards per carry and ranking in the bottom half of the league in rushing yardage. Time of possession has also been an issue, as the Saints often struggle to sustain drives and keep their defense off the field. Defensively, the Saints have shown flashes, particularly against the pass, but the unit has also been overextended due to offensive inefficiency. When they fall behind early, the defense is forced into situations where they must take risks, opening the door for opponents to exploit them on the ground. To win this matchup, New Orleans must control tempo, avoid early deficits, and find a way to keep the offense on schedule — easier said than done given recent trends.

Carolina, meanwhile, comes into this matchup in much better recent form. The Panthers have leaned heavily on their rushing attack, averaging over 140 rushing yards per game, which ranks among the best in the league. That ground game has allowed them to control the clock and take pressure off their passing attack. And when their offense stays balanced, they have managed to stay competitive even against stronger opponents. Defensively, the Panthers have been inconsistent, but they match up well here against a Saints offense that has struggled to produce explosive plays. Carolina’s ability to win at the line of scrimmage offensively could be the biggest difference-maker in this one, especially if they force New Orleans to play from behind. Their recent wins over teams like Dallas and Miami demonstrate that when they execute their run-first identity, they are capable of dictating game flow and wearing down opponents over four quarters. With momentum, confidence, and a favorable matchup on the ground, the Panthers appear positioned to take advantage of a Saints team still searching for answers.

Saints vs Panthers Prediction: Head to Head

Date	Opponent	Score	Spread	Total	Moneyline
11/03/24	@CAR	CAR 23-22	CAR+1.0	O40.5	CAR-102
9/08/24	@NO	NO 47-10	NO-4.5	O39.5	NO-215
12/10/23	@NO	NO 28-6	NO-2.5	U42.5	NO-135
9/18/23	@CAR	NO 20-17	CAR-1.0	U43	CAR-105
1/08/23	@NO	CAR 10-7	NO-3.5	U39	NO-195
9/25/22	@CAR	CAR 22-14	CAR+2.0	U42.5	CAR+110
1/02/22	@NO	NO 18-10	NO-6.5	U48	NO-330
9/19/21	@CAR	CAR 26-7	CAR+3.0	U44.5	CAR+145
1/03/21	@CAR	NO 33-7	CAR+6.0	U46.5	CAR+225
10/25/20	@NO	NO 27-24	NO-7.0	O50.5	NO-335

Date	Opponent	Score	Spread	Total	Moneyline
10/26/25	BUF	L 40-9	L+7.0	O47.5	L+250
10/19/25	@NYJ	W 13-6	W+1.5	U43.5	WEVEN
10/12/25	DAL	W 30-27	W+1.5	O46.5	WEVEN
10/05/25	MIA	W 27-24	W+1.5	O46.5	WEVEN
9/28/25	@NE	L 42-13	L+3.5	O45.5	L+145
9/21/25	ATL	W 30-0	W-1.5	U46.5	W-120
9/14/25	@ARI	L 27-22	L+4.5	O46.5	L+164
9/07/25	@JAC	L 26-10	L+2.5	U46.5	L+120
1/05/25	@ATL	W 44-38	W+6.5	O45.5	W+225
12/29/24	@TB	L 48-14	L+4.5	O48	L+170

Saints vs Panthers Prediction: New Orleans Offense

Saints vs Panthers Prediction: Carolina Offense

Saints vs Panthers Prediction and Pick, Week 10, by YouWager.lv.