Colts vs Rams Betting Prediction Week 4, 2025
Colts vs Rams Betting Prediction Week 4, 2025. Place a bet on this NFL football game with the best odds.
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The Week 4 matchup between the Indianapolis Colts and Los Angeles Rams shapes up as one of the most intriguing betting opportunities of the young 2025 NFL season.
Colts vs Rams Betting Prediction
From a betting perspective, this game carries plenty of intrigue for both sides. Indianapolis has proven to be one of the league’s most profitable ATS teams this season, while Los Angeles remains one of the NFL’s most consistent performers at home and against AFC foes. Trends point toward another high-scoring contest, as the last seven meetings between these two clubs have all gone over the total. With the Colts’ explosive offense clashing against the Rams’ efficiency and historical dominance, Week 4 offers a compelling case for bettors to expect fireworks. Whether backing the underdog Colts to continue their ATS streak or siding with the Rams’ proven reliability, this matchup is set to be a marquee betting highlight of the week.
Colts vs Rams Betting Prediction: Head to Head
Date | Team | Opp | Close | Result | ATS/OU |
---|---|---|---|---|---|
Oct 1, 2023 | Colts | Rams | +1.5 / 44.5 | Lost 23-29 | Lost / Over |
Sep 19, 2021 | Colts | Rams | +4.5 / 48 | Lost 24-27 | Won / Over |
Sep 10, 2017 | Colts | @Rams | +3.5 / 41.5 | Lost 9-46 | Lost / Over |
Aug 29, 2015 | Colts | Rams | -2 / 41.5 | Lost 0-0 | Lost / Under |
Nov 10, 2013 | Colts | @Rams | +7.5 / 43 | Lost 0-0 | Won / Under |
Aug 12, 2012 | Colts | @Rams | +2 / 35 | Lost 0-0 | Won / Under |
Aug 13, 2011 | Colts | Rams | -7 / 34 | Lost 0-0 | Lost / Under |
Oct 25, 2009 | Colts | Rams | +14 / 45 | Lost 0-0 | Won / Under |
Aug 10, 2006 | Colts | Rams | -5 / 39 | Lost 0-0 | Lost / Under |
Oct 17, 2005 | Colts | @Rams | +13.5 / 51 | Lost 0-0 | Won / Under |
Colts vs Rams Betting Prediction: Indianapolis
The Colts have been red-hot out of the gate, starting with an undefeated run powered by an offense that ranks second in scoring and third in rushing. Anthony Richardson and company have not only moved the ball at will, but they’ve done so with balance, efficiency, and discipline—posting zero turnovers so far this year. Indianapolis bettors have cashed tickets repeatedly, as the Colts are 5-1 against the spread in their last six games. While history has not been kind to Indianapolis in this series, the current form and offensive firepower they bring to Los Angeles cannot be overlooked.
Colts vs Rams Betting Prediction: Indianapolis Trends
- The over/under record for Indianapolis’s previous six games is 4-2.
- For the past six games, the total has been over in five of Indianapolis’ games.
- In its last six games, Indianapolis has a winning record of 5-1 against the spread.
- Indianapolis has a record of 3-7 versus the Los Angeles Rams in their last ten games.
- In its last five games against the Los Angeles Rams, Indianapolis has a losing record of 1-4 on the road.
- On the road, the total has been over in four of the previous five games that Indianapolis has played.
- The Indianapolis Colts have a losing record of 1-4 on the road versus the Los Angeles Rams in their last five games.
- Over the course of the last six games that Indianapolis has played against teams from the National Football Conference, the total has been underrated in five of those games.
- In its last 11 games against teams from the National Football Conference West division, Indianapolis has a winning percentage of 3-8 versus the opponent.
- In its last five games played in September, Indianapolis has a perfect record against the spread (ATS).
Indianapolis Last 10 Games
Date | Opponent | Score | Spread | Total | Moneyline |
---|---|---|---|---|---|
9/21/25
|
@TEN
|
W 41-20
|
W+1.5
|
O45.5
|
W+102
|
9/14/25
|
DEN
|
W 29-28
|
W+3.5
|
O44.5
|
W+145
|
9/07/25
|
MIA
|
W 33-8
|
W-1.5
|
U45.5
|
W-116
|
1/05/25
|
JAC
|
W 26-23
|
W-1.5
|
O46.5
|
W-122
|
12/29/24
|
@NYG
|
L 45-33
|
L-2.0
|
O43.5
|
L-130
|
12/22/24
|
TEN
|
W 38-30
|
W-3.5
|
O44.5
|
W-175
|
12/15/24
|
@DEN
|
L 31-13
|
L-2.5
|
U44.5
|
L-142
|
12/01/24
|
@NE
|
W 25-24
|
L-2.0
|
O44
|
W-125
|
11/24/24
|
DET
|
L 24-6
|
L+2.5
|
U47.5
|
L+114
|
11/17/24
|
@NYJ
|
W 28-27
|
W+4.0
|
O46
|
W+160
|
Colts vs Rams Betting Prediction: Indianapolis Offense
Overall
IND Offense | Off. Rank | Stat | Def. Rank | LAR Defense |
---|---|---|---|---|
34.33 | 2 | Points Scored | 14 | 20.33 |
265.33 | 5 | Passing Yards | 6 | 165.33 |
153.33 | 3 | Rushing Yards | 12 | 103.00 |
33:10 | 3 | Time on Field | 18 | 30:42 |
63.33 | 12 | Number of Plays | 20 | 61.33 |
6.61 | 1 | Yards Per Play | 4 | 4.38 |
Scoring
IND Offense | Off. Rank | Stat | Def. Rank | LAR Defense |
---|---|---|---|---|
34.33 | 2 | Points Scored | 14 | 20.33 |
8.67 | 3 | First Quarter | 10 | 3.33 |
11.33 | 3 | Second Quarter | 17 | 6.33 |
6.67 | 4 | Third Quarter | 26 | 5.67 |
7.67 | 10 | Fourth Quarter | 9 | 5.00 |
Passing
IND Offense | Off. Rank | Stat | Def. Rank | LAR Defense |
---|---|---|---|---|
265.33 | 5 | Passing Yards | 6 | 165.33 |
29.33 | 25 | Pass Attempts | 12 | 30.67 |
21.00 | 14 | Pass Completions | 11 | 19.67 |
0.67 | 1 | Sacks | 2 | 4.00 |
6.67 | 30 | Sack Yards | 32 | 31.00 |
12.63 | 1 | Yards Per Pass | 5 | 8.41 |
Rushing
IND Offense | Off. Rank | Stat | Def. Rank | LAR Defense |
---|---|---|---|---|
153.33 | 3 | Rushing Yards | 12 | 103.00 |
33.33 | 2 | Rush Attempts | 18 | 26.67 |
4.60 | 11 | Yards Per Rush | 11 | 3.86 |
Turn Overs
IND Offense | Off. Rank | Stat | Def. Rank | LAR Defense |
---|---|---|---|---|
0.00 | 3 | Interceptions | 24 | 0.33 |
0.00 | 2 | Fumbles | 12 | 1.00 |
0.00 | 5 | Fumbles Lost | 5 | 1.00 |
0.00 | 2 | Total Turnovers | 12 | 1.33 |
6.33 | 10 | Penalties | 8 | 8.67 |
45.33 | 9 | Penalty Yards | 11 | 64.00 |
Drives & Special Teams
IND Offense | Off. Rank | Stat | Def. Rank | LAR Defense |
---|---|---|---|---|
33:10 | 3 | Time on Field | 18 | 30:42 |
63.33 | 12 | Number of Plays | 20 | 61.33 |
6.61 | 1 | Yards Per Play | 4 | 4.38 |
0.33 | 1 | Punts | 10 | 4.33 |
46.00 | 23 | Punt Average | 29 | 52.31 |
107.67 | 23 | Return Yards | 1 | 68.67 |
Colts vs Rams Betting Prediction: Los Angeles
The Rams enter Week 4 with momentum of their own, despite suffering a setback against Philadelphia. Los Angeles is 8-3 in its last 11 games, thriving both at home and against AFC competition. The Rams’ balanced attack has given opponents problems, ranking top-10 in both rushing and passing yards while averaging nearly six yards per play. Historically, the Rams have been the Colts’ kryptonite, winning four of the last five meetings between the two franchises and consistently cashing overs in head-to-head matchups. For bettors, the Rams’ dominance against the AFC South—an incredible 11-1 record in their last 12 games—adds another layer of confidence in their ability to handle business here.
Colts vs Rams Betting Prediction: Los Angeles Trends
- The Los Angeles Rams have a record of 5-1 against the spread in their previous six games.
- In four of the last six games that the Los Angeles Rams have played, the total has been higher than the point spread.
- The Los Angeles Rams have a winning record of 8-3 in their previous 11 games.
- Seven out of the last seven games that the Los Angeles Rams have played versus Indianapolis have resulted in the total going over.
- The Los Angeles Rams have a record of 4-1 against the spread in their previous five games played at home.
- In their last five games versus Indianapolis, the Los Angeles Rams have a winning record of 4-1 against the spread.
- Versus the spread, the Los Angeles Rams have a perfect record of 5-0 in their last five games versus teams from the American Football Conference.
- The Los Angeles Rams have a winning record of 11-1 in their previous 12 games versus teams that are members of the American Football Conference South division.
- In the last six games that the Los Angeles Rams have played in the month of September, the total has gone over in five of those games.
- Six out of the eight games that the Los Angeles Rams have played in week 4 have seen the total go over.
Los Angeles Last 10 Games
Date | Opponent | Score | Spread | Total | Moneyline |
---|---|---|---|---|---|
9/21/25
|
@PHI
|
L 33-26
|
L+4.5
|
O46.5
|
L+170
|
9/14/25
|
@TEN
|
W 33-19
|
W-4.5
|
O45.5
|
W-205
|
9/07/25
|
HOU
|
W 14-9
|
W-2.5
|
U46.5
|
W-146
|
1/19/25
|
@PHI
|
L 28-22
|
L+5.5
|
O44.5
|
L+198
|
1/13/25
|
MIN
|
W 27-9
|
W+2.5
|
U47.5
|
W+110
|
1/05/25
|
SEA
|
L 30-25
|
L-5.5
|
O47
|
L-225
|
12/28/24
|
ARI
|
W 13-9
|
L-5.5
|
U48.5
|
W-238
|
12/22/24
|
@NYJ
|
W 19-9
|
W+3.0
|
U47.5
|
W+130
|
12/12/24
|
@SF
|
W 12-6
|
W+7.0
|
U47.5
|
W+260
|
12/08/24
|
BUF
|
W 44-42
|
W+1.0
|
O48
|
W-105
|
Colts vs Rams Betting Prediction: Los Angeles Offense
Overall
IND Defense | Def. Rank | Stat | Off. Rank | LAR Offense |
---|---|---|---|---|
18.67 | 9 | Points Scored | 11 | 24.33 |
178.33 | 8 | Passing Yards | 10 | 236.67 |
94.00 | 8 | Rushing Yards | 9 | 127.00 |
26:49 | 3 | Time on Field | 20 | 29:17 |
55.00 | 5 | Number of Plays | 21 | 60.67 |
4.95 | 15 | Yards Per Play | 5 | 5.99 |
Scoring
IND Defense | Def. Rank | Stat | Off. Rank | LAR Offense |
---|---|---|---|---|
18.67 | 9 | Points Scored | 11 | 24.33 |
3.33 | 8 | First Quarter | 12 | 5.67 |
5.67 | 13 | Second Quarter | 20 | 6.33 |
4.67 | 19 | Third Quarter | 2 | 8.00 |
5.00 | 7 | Fourth Quarter | 29 | 4.33 |
Passing
IND Defense | Def. Rank | Stat | Off. Rank | LAR Offense |
---|---|---|---|---|
178.33 | 8 | Passing Yards | 10 | 236.67 |
33.00 | 21 | Pass Attempts | 19 | 32.00 |
21.33 | 17 | Pass Completions | 16 | 21.00 |
2.33 | 14 | Sacks | 9 | 1.67 |
12.00 | 12 | Sack Yards | 26 | 9.67 |
8.36 | 4 | Yards Per Pass | 6 | 11.27 |
Rushing
IND Defense | Def. Rank | Stat | Off. Rank | LAR Offense |
---|---|---|---|---|
94.00 | 8 | Rushing Yards | 9 | 127.00 |
19.67 | 2 | Rush Attempts | 13 | 27.00 |
4.78 | 25 | Yards Per Rush | 9 | 4.70 |
Turn Overs
IND Defense | Def. Rank | Stat | Off. Rank | LAR Offense |
---|---|---|---|---|
1.33 | 6 | Interceptions | 17 | 0.67 |
0.33 | 28 | Fumbles | 20 | 1.00 |
0.33 | 18 | Fumbles Lost | 13 | 0.33 |
1.67 | 7 | Total Turnovers | 14 | 1.00 |
6.33 | 21 | Penalties | 7 | 5.00 |
55.33 | 15 | Penalty Yards | 8 | 43.33 |
Drives & Special Teams
IND Defense | Def. Rank | Stat | Off. Rank | LAR Offense |
---|---|---|---|---|
26:49 | 3 | Time on Field | 20 | 29:17 |
55.00 | 5 | Number of Plays | 21 | 60.67 |
4.95 | 15 | Yards Per Play | 5 | 5.99 |
1.67 | 31 | Punts | 9 | 3.00 |
45.62 | 6 | Punt Average | 25 | 44.54 |
151.00 | 25 | Return Yards | 19 | 114.33 |
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