Panthers vs Cardinals Prediction NFL Week 2 Predictions. Place a bet on this NFL football game with the best lines and bonuses at YouWager.lv.

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Panthers vs Cardinals Prediction NFL Week 2 Predictions

The Carolina Panthers were the underdogs in Week 1, and they were playing on the road against a team that had one less victory than they did in the previous season. It is not at all surprising that, in light of the absolutely revolting performance the team put up in that game, the same would be true on the road against a team that came really close to qualifying for the playoffs in 2024.

In week two, the Panthers have a significant uphill battle ahead of them. The second-largest line between two teams on YouWager is the 6.5-point advantage that the Arizona Cardinals are given at the start of the game. The Buffalo Bills are the only team with a higher spread, with a 7.5-point advantage over the New York Jets. However, it is possible to make the case that one should decrease in size, while the line between Carolina and Arizona could be expanded.

Additionally, the over/under is not very favorable at all. With the line set at 45.5 points, the oddsmakers are not anticipating a large number of points in this game. The under has a modest advantage at -115 to -105, indicating that the odds makers in Vegas are not very optimistic about these offenses. In other words, the odds are that Nevada anticipates that North Carolina will be defeated by a score of approximately 27-19.

Carolina is not favored by the moneyline in any way whatsoever. They have odds of +220 to emerge victorious, while Arizona has odds of -270. In week two, Carolina is essentially the simplest opponent for any team because only the Buffalo Bills and the Baltimore Ravens have greater chances of winning.

Although it provides a distasteful picture of the current situation of the Panthers, it is difficult to argue with them. The defense was unable to provide any pressure on the opposing team’s quarterback, and it was also ineffective in stopping the run. The offense was unable to advance the ball down the field very effectively, and the running game was restricted before it was ultimately abandoned.

It appears as though the team has more deficiencies this year than it had the year before, which is difficult to believe. By the conclusion of the year 2024, the questions that they had been asking had seemingly vanished, and they had been replaced with new inquiries regarding the front office, the coach, and the quarterback.

The oddsmakers are definitely not convinced that the Panthers have the potential to turn things around, especially after nothing they tried on Sunday was successful. It is possible that the fact that the Cardinals have historically dominated the Cubs is the only thing that works in their favor. They have a winning record against Arizona, having defeated them fourteen times and only lost to them six times.

Panthers vs Cardinals Prediction NFL Week 2 Predictions: Head to Head

Date	Opponent	Score	Spread	Total	Moneyline
12/22/24	@CAR	CAR 36-30	CAR+1.0	O45.5	CAR-102
10/02/22	@CAR	ARI 26-16	CAR+3.0	U46.5	CAR+120
11/14/21	@ARI	CAR 34-10	ARI-6.0	U49.5	ARI-275
10/04/20	@CAR	CAR 31-21	CAR+3.0	O51.5	CAR+143
9/22/19	@ARI	CAR 38-20	ARI-2.5	O44.5	ARI-130
10/30/16	@CAR	CAR 30-20	NL	NL	NL
1/24/16	@CAR	CAR 49-15	NL	NL	NL
1/03/15	@CAR	CAR 27-16	NL	NL	NL
10/06/13	@ARI	ARI 22-6	NL	NL	NL
9/11/11	@ARI	ARI 28-21	NL	NL	NL

Panthers vs Cardinals Prediction NFL Week 2 Predictions: Team Previews

From a betting perspective, this game presents an interesting contrast between long-term history and current form. Carolina’s historical dominance against Arizona can’t be ignored, but their present struggles on both sides of the ball make them hard to back with confidence. The Panthers are 2-16 straight up in their last 18 away games, a brutal stat that underscores their inability to win on the road. Arizona, meanwhile, has been trending in the right direction and is 4-1 straight up in its last five games, showing growth and balance at a crucial point in the season. The total line is set at 45.5, with oddsmakers slightly favoring the under, projecting a controlled game where Arizona does just enough to secure a 27-19 type of victory. For bettors, this matchup suggests a strong lean toward Arizona covering the spread, with value in the under depending on Carolina’s offensive output.

Panthers vs Cardinals Prediction NFL Week 2 Predictions: Carolina

Now in this Panthers vs Cardinals Prediction NFL Week 2 Predictions, we have the Carolina betting preview.

The Carolina Panthers find themselves in a difficult position entering Week 2 of the NFL season. After a poor showing in their opener, where both sides of the ball failed to execute, the Panthers now travel west to face an Arizona Cardinals team with playoff aspirations. Carolina’s offensive struggles were glaring in Week 1, as they failed to establish the run and could not move the ball consistently downfield. The defense fared no better, showing little ability to generate pressure on the opposing quarterback while allowing significant yardage in the ground game. Oddsmakers have set the line at Arizona -6.5, a reflection of how far Carolina has fallen in expectations compared to their NFC counterparts. Despite their past dominance in head-to-head matchups against the Cardinals, including a 7-1 record in the last eight meetings, the Panthers’ current form paints a grim outlook.

Panthers vs Cardinals Prediction NFL Week 2 Predictions: Carolina Trends

Next in this Panthers vs Cardinals Prediction NFL Week 2 Predictions, we have the Carolina trends:

• Over the past ten games that Carolina has played, their record is 7–3 against the spread.
• The total score has exceeded expectations in four out of the past five games played by Carolina.
• Over the course of its most recent 20 games, Carolina has held a win-loss record of 5–15 SU.
• In the past eight meetings between these two teams, Carolina has a 7–1 advantage in their head-to-head matchups versus Arizona.
• Over the past eight games that Carolina has played versus Arizona, it has a record of 7 wins and 1 loss.
• Over the course of its last eighteen away games, Carolina has posted a straight-up (SU) record of 2–16.
• When playing on the road versus Arizona, Carolina has a record of 6–2 SU in its last eight games.
• In five of Carolina’s last six matchups against an opponent in the National Football Conference, the total has gone OVER.
• In the last 13 contests that Carolina has played against a National Football Conference West division opponent, the total has exceeded the predicted number of points 10 times.
• Over the course of the last six games that Carolina has played in September, it has had a win-loss record of 1-5 against the spread.

Carolina Last 10 Games

Date	Opponent	Score	Spread	Total	Moneyline
9/07/25	@JAC	L 26-10	L+2.5	U46.5	L+120
1/05/25	@ATL	W 44-38	W+6.5	O45.5	W+225
12/29/24	@TB	L 48-14	L+4.5	O43.5	L+170
12/22/24	ARI	W 36-30	W+1.0	O45.5	W-102
12/15/24	DAL	L 30-14	L+6.5	P44	L+225
12/08/24	@PHI	L 22-16	W+7.0	U45	L+250
12/01/24	TB	L 26-23	L+2.0	O44	L+105
11/24/24	KC	L 30-27	W+7.0	O45.5	L+250
11/10/24	NYG	W 20-17	W+1.0	U40.5	W+112
11/03/24	NO	W 23-22	W+1.0	O40.5	W-102

Panthers vs Cardinals Prediction NFL Week 2 Predictions: Arizona

Now in this Panthers vs Cardinals Prediction NFL Week 2 Predictions, we have the Arizona betting preview.

On the other side, the Arizona Cardinals enter this matchup with momentum and confidence after an impressive Week 1 victory over the New Orleans Saints. Their defense played disciplined football, forcing key stops while limiting explosive plays, and their offense showed balance between the run and pass game. Oddsmakers recognize this stability, giving Arizona -270 odds on the moneyline and projecting them as one of the most likely winners of Week 2. In fact, only Buffalo and Baltimore are heavier favorites this week. Arizona’s recent betting trends also work in their favor, covering spreads consistently against NFC South opponents and posting strong home records both straight up and against the spread. While their history against Carolina has been shaky, the Cardinals appear to be the more complete team heading into this clash.

Panthers vs Cardinals Prediction NFL Week 2 Predictions: Arizona Trends

Next in this Panthers vs Cardinals Prediction NFL Week 2 Predictions, we have the Arizona trends:

• Over the course of its last five matches, Arizona has a record of 4 wins and 1 loss.
• The total has gone over in four of Arizona’s last six games.
• The total has gone over in six of the last eight matchups between Arizona and Carolina.
• The Arizona Coyotes have a record of 5–1 against the spread in their previous six home games.
• In four out of the last five times that Arizona has played Carolina on their home turf, the total points scored has exceeded expectations.
• The Arizona Cardinals have a 2-5 straight up record in their most recent seven matches versus a National Football Conference team.
• Arizona has a 6-1 against-the-spread record in its previous seven games against opponents in the National Football Conference South division.
• In September, the total has gone OVER in five out of the last seven games that Arizona has played.
• Over the course of the last five games that Arizona has played in week two, they have a 4–1 SU record.

Arizona Last 10 Games

Date	Opponent	Score	Spread	Total	Moneyline
9/07/25	@NO	W 20-13	W-4.5	U41.5	W-200
1/05/25	SF	W 47-24	W+5.5	O43	W+190
12/28/24	@LAR	L 13-9	W+5.5	U48.5	L+195
12/22/24	@CAR	L 36-30	L-1.0	O45.5	L-118
12/15/24	NE	W 30-17	W-3.0	O44	W-155
12/08/24	SEA	L 30-18	L-1.0	O47.5	L-112
12/01/24	@MIN	L 23-22	W+1.5	U45.5	LEVEN
11/24/24	@SEA	L 16-6	L-1.0	U45.5	L-115
11/10/24	NYJ	W 31-6	W+3.0	U46.5	W+130
11/03/24	CHI	W 29-9	W+1.0	U46.5	W-108

 

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