49ers vs Seahawks Prediction and Pick, NFL Divisional Round Picks. Place a bet on this game with the best odds.

49ers vs Seahawks Prediction – NFL Divisional Round Picks

Now we have the 49ers vs Seahawks Prediction for both teams.

49ers vs Seahawks Prediction – 49ers Divisional Round Picks

With the NFL Playoffs Divisional Round action taking place at Lumen Field on Saturday, the San Francisco 49ers and the Seattle Seahawks will square off against each other. This is a prediction for the 49ers versus the Seahawks. From a betting standpoint, we will analyze this situation in order to find the best choice for the 49ers versus the Seahawks. We are going to look at the current form and player performances of both sides, as well as the previous betting patterns and streaks that are associated with this encounter. Towards the end of this discussion, we will bring everything together by providing a synopsis that generates a rational selection for a betting outcome that is advantageous in this game.

A shaky 6-4 run was all that the Niners were able to pull off in their first ten games of the season. Over that span of time, the team suffered defeats at the hands of the Jaguars, Buccaneers, Texans, and Rams. After that, San Francisco would go on a winning streak of six games, during which they would defeat the Cardinals, Panthers, Browns, Titans, Colts, and Bears. At the end of the regular season, they would suffer a defeat at the hands of Seattle. During those 17 games, San Francisco had a streak of 12 wins and 5 losses.

At the beginning of the fourth quarter of the Wild Card Round game that San Francisco played against the Eagles the previous weekend, the team was trailing by six points, 16-10. The Niners triumphed in a comeback victory by a score of 23-19, despite the fact that they conceded points in each and every frame. After completing 18 of 31 passes, quarterback Brock Purdy finished with 262 yards, two touchdowns, and two interceptions. Demarcus Robinson got 111 yards and a touchdown on six catches, and Christian McCaffrey added 15 carries for 48 yards (with two receiving touchdowns). McCaffrey also scored two receiving touchdowns.

49ers vs Seahawks Prediction – Seahawks Divisional Round Picks

On the Seattle side, they made it through their first ten games of the year with a nice 7-3 run putting them in first place. At that period, the Seahawks were defeated by only three teams: the 49ers, the Buccaneers, and the Rams. The Titans, Vikings, Falcons, Colts, Rams, Panthers, and 49ers were all defeated by Seattle as the regular season came to an end. Seattle finished the season on a strong note. That would give Seattle a fantastic overall record of 14-3 for the course of the regular season, which consists of 17 games.

At the beginning of the first half of their final game of the regular season, which was played against the 49ers, the Seahawks held a 10-3 lead. The lead would remain the same throughout the remainder of the game, and Seattle would emerge victorious with a score of 13-3 in the end. Kenneth Walker was the leading rusher with 16 carries for 97 yards, and quarterback Sam Darnold finished with 198 yards after completing 20 of 26 passes for a total of 198 yards. During his time as the team’s leading receiver, Jaxson Smith-Njigba amassed 84 yards through six receptions.

49ers vs Seahawks Prediction – Our Divisional Round Pick

All right, we’ll stick with the Seahawks. However, regardless of the outcome, we should be in for another close and intense game here today. Seattle was able to keep San Francisco’s offense in check during their victory on the road in Week 18. They were able to limit the Niners to only 173 yards (53 rushing), nine first downs, and two of nine attempts after third down. On the other hand, the Seahawks were able to throw for 181 yards and 361 yards, with 23 first downs and a completion percentage of 6 out of 13 on third-down tries. San Francisco will be looking to score as many points as possible in this matchup because Seattle has held its opponents to fewer than 17 points in five of the last six games.

Regarding San Francisco, they were able to get a good victory on the road against Philadelphia last weekend. They had 361 overall yards, 286 pass yards, 6.2 yards per play, 20 first downs, and they were successful on six out of eleven third-down attempts. Over the course of the game, the 49ers allowed only 167 passing yards to the opposing team and converted only five of sixteen third-down opportunities.

Prior to their loss to Seattle in Week 18, San Francisco had played three consecutive games in which they scored 37 points or more. Because these teams are familiar with one another, it is possible that we will witness some clever tricks on either side. Watching it is going to be a delightful experience.

Our 49ers vs Seahawks Pick: SEATTLE SEAHAWKS

49ers vs Seahawks Odds

Now, we have the 49ers vs Seahawks odds:

TEAM | SPREAD | MONEYLINE | TOTAL
49ers | +7.5 | +280 | 45 O
Seahawks | -7.5 | -360 | 45 U

49ers Futures Odds, and Seahawks Futures Odds

49ers NFC Championship Odds, and Seahawks NFC Championship Odds

Now, we have the 49ers NFC Championship Odds, and Seahawks NFC Championship Odds:

TEAM | CONFERENCE ODDS
49ers NFC Championship Odds | +800
Seahawks NFC Championship Odds | +120

49ers vs Seahawks Prediction: Trends

All twelve of the Seahawks’ most recent games have been won by the betting favorites.

Since the absence of Christian McCaffrey, the 49ers have been unsuccessful in each of their last four games.

Over the course of the last eight games that have taken place at Lumen Field between the 49ers and the Seahawks, the favorites have covered the spread seven times.

Since the absence of Christian McCaffrey, the 49ers have not been able to cover the spread in any of their last four games.

Each of the last five games that the 49ers have played as underdogs after a victory, they have lost the opening quarter of each of those games.

After a victory, the 49ers have been the underdogs in each of their last five games, and they have started each of those games with a loss.

Without Brayden Willis, the 49ers have been victorious in eight of their previous nine games played away from home.

Over the course of the last six postseason games, the Seahawks have suffered five defeats.

Without Uchenna Nwosu, the Seahawks have been an underdog in seven of their previous eight games, and they have failed to cover the spread in seven of those games.

When it comes to the 49ers and Seahawks, the road team has covered the spread in seven out of the last eight games between the two teams.

In three of their last four postseason games against players from the National Football Conference, the Seahawks have been defeated in the first quarter of the game.

Over the course of their last six games, the 49ers have won the first half of five of those games after a victory.

In each of the last seven postseason games that the 49ers have played as underdogs, the total number of points has been UNDER the line.

In each of the last four games that the Seahawks have played in the Divisional Round, the total number of points has been OVER.

Over the total points line has been seen in four of the last five games that have been played between clubs from the NFC West.

The Seahawks have been the favorites in each of their previous three games, and Zach Charbonnet has scored the first touchdown in each of those games.

In each of the last five games that the Seahawks have played against teams from the NFC West, Kenneth Walker III has rushed for more than 67 yards versus those teams.

During the Seahawks’ most recent nine games played at Lumen Field, Jaxon Smith-Njigba has accumulated more than 93 receiving yards in eight of those games.

During his last five home games against National Football Conference opponents, Zach Charbonnet has scored a touchdown in each of those games.

Every single one of the Seahawks’ most recent four games against NFC opponents has resulted in Zach Charbonnet accumulating more than 54 yards rushing and receiving.

As we head into the Divisional Round, Jaxon Smith-Njigba has completed five consecutive games (including playoffs) with a receiving yardage total of fifty or more. This streak is tied for the longest in the National Football League.

During the 49ers’ most recent three road games against National Football Conference opponents, Christian McCaffrey has scored two touchdowns or more in each of those games.

In the last six games that the 49ers have played away from home against NFC opponents, Christian McCaffrey has scored at least one touchdown in each of those contests.

More than 57 yards on the ground have been accumulated by Christian McCaffrey in each of his six prior appearances with his team, all of which were against NFC West opponents and were played away from home.

After a victory on the road, Mac Jones has achieved a passing yardage total of 279 or more in each of his four previous consecutive appearances.

During his last twelve games with his team, Kendrick Bourne has recorded more than sixteen yards rushing and receiving in eleven of those games. These games have been played away from home against NFC opponents.

Over the course of his last six appearances in January, Demarcus Robinson has scored at least 23 receiving yards in each of those games.

Over the course of his last five games versus NFC West opponents, Mac Jones has completed more than 24 passes in four of those appearances.

As the Divisional Round approaches, Brock Purdy has tallied the same number of throwing touchdowns in a single game as any other player in the season, with five of them coming against the Colts in Week 16.

Heading into the Divisional Round, two separate Seahawks players have each recorded more than one hundred yards rushing in a single game this season, making them tied for the most in the National Football League.

During the regular season, the Seahawks had the highest points allowed per game (17.2) of any team in the National Football League.

During the regular season, the 49ers had a punt average of 43.6 yards, which placed them 32nd in the National Football League.

The 49ers finished the regular season with a third-down percentage of 49.8 percent, which was the highest in the National Football League.

49ers vs Seahawks Prediction: Head to Head

Date | Opponent | Score | Spread | Total | Moneyline

1/03/26

@SF

SEA 13-3

SF-4.5

U48.5

SF-198

9/07/25

@SEA

SF 17-13

SEA+1.5

U45.5

SEA+106

11/17/24

@SF

SEA 20-17

SF-6.5

U47.5

SF-410

10/10/24

@SEA

SF 36-24

SEA+4.0

O46.5

SEA+160

12/10/23

@SF

SF 28-16

SF-3.5

U46.5

SF-175

11/23/23

@SEA

SF 31-13

SEA+1.5

U46.5

SEAEVEN

1/14/23

@SF

SF 41-23

SF-9.5

O43.5

SF-480

12/15/22

@SEA

SF 21-13

SEA+1.5

U41.5

SEA+140

9/18/22

@SF

SF 27-7

SF-8.5

U43.5

SF-400

12/05/21

@SEA

SEA 30-23

SEA-1.5

O45.5

SEA-116

49ers vs Seahawks Prediction: 49ers Last 10 Games

Date | Opponent | Score | Spread | Total | Moneyline

1/11/26

@PHI

W 23-19

W+3.0

U46

W+130

1/03/26

SEA

L 13-3

L-4.5

U48.5

L-198

12/28/25

CHI

W 42-38

W-3.5

O46.5

W-180

12/22/25

@IND

W 48-27

W-3.0

O46.5

W-155

12/14/25

TEN

W 37-24

W-7.5

O45.5

W-325

11/30/25

@CLE

W 26-8

W-6.0

U43.5

W-250

11/24/25

CAR

W 20-9

W-7.0

U46.5

W-298

11/16/25

@ARI

W 41-22

W-1.5

O47.5

W-120

11/09/25

LAR

L 42-26

L-1.5

O46.5

L-120

11/02/25

@NYG

W 34-24

W-3.5

O44.5

W-180

49ers vs Seahawks Prediction: Seahawks Last 10 Games

Date | Opponent | Score | Spread | Total | Moneyline

1/03/26

@SF

W 13-3

W+4.5

U48.5

W+164

12/28/25

@CAR

W 27-10

W-1.5

U43.5

W-120

12/18/25

LAR

W 38-37

W+1.5

O44.5

WEVEN

12/14/25

IND

W 18-16

L-3.5

U44.5

W-175

12/07/25

@ATL

W 37-9

W+1.5

O45.5

WEVEN

11/30/25

MIN

W 26-0

W-7.5

U43.5

W-120

11/23/25

@TEN

W 30-24

W-1.5

O44.5

W-120

11/16/25

@LAR

L 21-19

W+4.5

U45.5

L+164

11/09/25

ARI

W 44-22

W-1.5

O44.5

W-120

11/02/25

@WAS

W 38-14

W+5.5

O47.5

W+185

49ers vs Seahawks Prediction: 49ers Offense

Overall

SF Offense | Off. Rank | Stat | Def. Rank | SEA Defense
25.56 | 10 | Points Scored | 2 | 17.18
246.83 | 5 | Passing Yards | 9 | 193.94
105.11 | 25 | Rushing Yards | 3 | 91.65
30:31 | 13 | Time on Field | 15 | 30:11
63.33 | 10 | Number of Plays | 22 | 62.65
5.56 | 11 | Yards Per Play | 2 | 4.56

Scoring

SF Offense | Off. Rank | Stat | Def. Rank | SEA Defense
25.56 | 10 | Points Scored | 2 | 17.18
5.67 | 7 | First Quarter | 2 | 3.00
7.44 | 10 | Second Quarter | 1 | 4.29
5.17 | 12 | Third Quarter | 6 | 3.29
7.11 | 12 | Fourth Quarter | 13 | 6.18

Passing

SF Offense | Off. Rank | Stat | Def. Rank | SEA Defense
246.83 | 5 | Passing Yards | 9 | 193.94
33.67 | 11 | Pass Attempts | 28 | 35.29
23.17 | 6 | Pass Completions | 24 | 22.06
1.56 | 5 | Sacks | 9 | 2.76
9.22 | 30 | Sack Yards | 26 | 18.94
10.65 | 13 | Yards Per Pass | 1 | 8.79

Rushing

SF Offense | Off. Rank | Stat | Def. Rank | SEA Defense
105.11 | 25 | Rushing Yards | 3 | 91.65
28.11 | 12 | Rush Attempts | 6 | 24.59
3.74 | 30 | Yards Per Rush | 1 | 3.73

Turn Overs

SF Offense | Off. Rank | Stat | Def. Rank | SEA Defense
1.00 | 28 | Interceptions | 5 | 1.06
0.83 | 11 | Fumbles | 32 | 0.65
0.33 | 8 | Fumbles Lost | 21 | 0.41
1.33 | 20 | Total Turnovers | 6 | 1.47
4.67 | 2 | Penalties | 8 | 6.88
37.00 | 2 | Penalty Yards | 10 | 53.06

Drives & Special Teams

SF Offense | Off. Rank | Stat | Def. Rank | SEA Defense
30:31 | 13 | Time on Field | 15 | 30:11
63.33 | 10 | Number of Plays | 22 | 62.65
5.56 | 11 | Yards Per Play | 2 | 4.56
2.61 | 3 | Punts | 4 | 4.29
43.03 | 32 | Punt Average | 9 | 46.22
109.00 | 29 | Return Yards | 30 | 145.12

49ers vs Seahawks Prediction: Seahawks Offense

Overall

SF Defense | Def. Rank | Stat | Off. Rank | SEA Offense
21.67 | 12 | Points Scored | 2 | 28.41
228.78 | 22 | Passing Yards | 9 | 228.06
109.61 | 12 | Rushing Yards | 11 | 123.29
29:49 | 10 | Time on Field | 15 | 30:12
61.11 | 14 | Number of Plays | 24 | 59.71
5.54 | 22 | Yards Per Play | 6 | 5.88

Scoring

SF Defense | Def. Rank | Stat | Off. Rank | SEA Offense
21.67 | 12 | Points Scored | 2 | 28.41
4.17 | 15 | First Quarter | 4 | 6.24
7.11 | 18 | Second Quarter | 7 | 8.00
4.22 | 14 | Third Quarter | 1 | 7.12
6.17 | 12 | Fourth Quarter | 16 | 6.59

Passing

SF Defense | Def. Rank | Stat | Off. Rank | SEA Offense
228.78 | 22 | Passing Yards | 9 | 228.06
34.39 | 25 | Pass Attempts | 29 | 28.29
23.22 | 29 | Pass Completions | 24 | 19.12
1.17 | 32 | Sacks | 6 | 1.59
8.89 | 1 | Sack Yards | 26 | 10.94
9.85 | 13 | Yards Per Pass | 1 | 11.93

Rushing

SF Defense | Def. Rank | Stat | Off. Rank | SEA Offense
109.61 | 12 | Rushing Yards | 11 | 123.29
25.56 | 10 | Rush Attempts | 4 | 29.82
4.29 | 16 | Yards Per Rush | 25 | 4.13

Turn Overs

SF Defense | Def. Rank | Stat | Off. Rank | SEA Offense
0.33 | 31 | Interceptions | 26 | 0.88
1.11 | 12 | Fumbles | 32 | 1.53
0.56 | 11 | Fumbles Lost | 32 | 0.76
0.89 | 25 | Total Turnovers | 31 | 1.65
6.33 | 16 | Penalties | 9 | 5.88
43.44 | 29 | Penalty Yards | 10 | 46.65

Drives & Special Teams

SF Defense | Def. Rank | Stat | Off. Rank | SEA Offense
29:49 | 10 | Time on Field | 15 | 30:12
61.11 | 14 | Number of Plays | 24 | 59.71
5.54 | 22 | Yards Per Play | 6 | 5.88
3.33 | 19 | Punts | 8 | 3.06
48.56 | 27 | Punt Average | 5 | 49.01
129.50 | 21 | Return Yards | 20 | 116.88

All NFL Divisional Round Picks & Predictions

Learn more about NFL Betting here.Visit the Betting school and learn how to wager on the moneyline, spread, and total; on your favorite team or an undervalued underdog. Sign up with YouWager.lv now and get in the game with the best welcome bonus, click below:

49ers vs Seahawks Prediction and Pick, NFL Divisional Round Picks, by YouWager.lv.