Cardinals vs Packers Preseason Betting Prediction: Can Green Bay Cover as a Home Underdog?

Cardinals vs Packers Preseason Betting Prediction: Get Arizona vs Green Bay odds, spread, player props, same game parlay and best bet.

Cardinals vs Packers Preseason Betting Prediction: Cardinals vs Packers, Who Will Win Today?

The best bet in the Cardinals vs Packers Preseason Betting Prediction is the Green Bay Packers +2.5 at Lambeau Field.

Arizona enters Friday night as a 2.5-point road favorite, but the setup strongly favors Green Bay as the home underdog. Road favorites are unusual in preseason football, and this matchup gives the Packers several situational advantages that make the points particularly appealing.

Green Bay is playing its only home preseason game of 2026, while Matt LaFleur faces his younger brother Mike LaFleur for the first time as opposing NFL head coaches. The Packers are also coming off an impressive 33-13 victory over Denver, while Arizona was beaten 34-13 by Dallas.

The Cardinals are dealing with several injuries to important offensive players, including Trey Benson, James Conner and Carson Beck. Meanwhile, Green Bay’s backup quarterback Kyle McCord showed enough in Week 2 to provide confidence in the Packers’ depth.

The home-field advantage at Lambeau Field, Green Bay’s recent preseason form and the unusual road-favorite setup all point toward the Packers.

The Pick: Green Bay Packers +2.5

A Summary

The Cardinals vs Packers Preseason Betting Prediction favors Green Bay +2.5 because the Packers have the better situational profile despite being home underdogs.

Arizona is laying 2.5 points on the road, which immediately makes the matchup interesting. Preseason games are especially volatile because playing time, quarterback rotations and roster evaluations can change the expected matchup quickly.

Green Bay has several things working in its favor.

The Packers are playing their only home preseason game at Lambeau Field. The team is also coming off a dominant 33-13 road victory over Denver.

Kyle McCord completed 12 of 19 passes for 118 yards in that victory, while Green Bay outgained Denver 299-225.

Arizona enters the game after a very different performance.

The Cardinals lost 34-13 to Dallas and surrendered 413 total yards.

Arizona is also dealing with injuries at several important positions. Trey Benson has been placed on injured reserve with a knee issue, James Conner has been dealing with a foot issue, and Carson Beck has been limited with rib soreness.

The coaching storyline adds another fascinating layer.

Matt LaFleur will face his younger brother Mike LaFleur, who is beginning his first season as Arizona’s head coach.

While revenge or family motivation should never be the primary reason to make a wager, it can matter when it reinforces a matchup that already favors one side.

Green Bay’s defensive identity is another reason to like the home team.

The Packers have demonstrated an ability to create pressure and defend critical downs, while Arizona’s backup quarterback rotation faces the challenge of operating on the road.

The total is sitting around 37.5, and there is a reasonable case for the Under given the expected backup-heavy rotations.

But the strongest wager remains Green Bay +2.5.

Best Bet: Green Bay Packers +2.5

Table of Contents

Cardinals vs Packers Preseason Betting Prediction

Cardinals vs Packers Odds

What Is the Point Spread in NFL Betting?

Cardinals vs Packers Same Game Parlay

Cardinals vs Packers Player Props

Matt LaFleur vs Mike LaFleur

Green Bay’s Home-Field Advantage

Packers Preseason Performance

Cardinals Preseason Performance

Arizona’s Injury Situation

Green Bay’s Defensive Matchup

Cardinals vs Packers Follow-Up Questions

Cardinals vs Packers FAQ

Final Cardinals vs Packers Preseason Betting Prediction

Cardinals vs Packers Odds

The current Cardinals vs Packers odds have Arizona as a 2.5-point road favorite over Green Bay.

The total is approximately 37.5 points.

Betting Market | Current Number
Arizona Cardinals | -2.5
Green Bay Packers | +2.5
Game Total | 37.5
Favorite | Arizona Cardinals
Location | Lambeau Field
Kickoff | 8:00 PM ET
Date | Friday, August 28, 2026
Recommended Side | Green Bay Packers +2.5

The most notable part of the Cardinals vs Packers odds is the fact that Arizona is favored on the road.

Road favorites are uncommon in preseason football because home teams typically receive additional value from crowd energy, familiarity with the stadium and normal pregame routines.

That becomes particularly important at Lambeau Field.

Green Bay has only one home preseason game this year, giving Friday night’s game considerably more importance from an atmosphere perspective.

What Is the Point Spread in NFL Betting?

The NFL point spread is the number of points given to the underdog or required by the favorite to determine whether a bet covers.

With Arizona at -2.5, the Cardinals need to win by at least three points for an Arizona spread wager to cash.

Green Bay +2.5 covers if the Packers win outright or lose by two points or fewer.

That makes the Packers particularly attractive in a matchup expected to feature backup-heavy rotations.

Cardinals vs Packers Same Game Parlay

A Cardinals vs Packers same game parlay should be constructed around the expected game environment.

Potential selections include:

Green Bay Packers +2.5

Under 37.5 points

Arizona quarterback passing Under

Green Bay quarterback passing Over, depending on expected playing time

Select defensive player props

The most logical game script is a competitive, relatively low-scoring game.

Both teams are expected to rely heavily on backup personnel.

Arizona is also dealing with injuries that could weaken its offensive depth.

Green Bay’s defense has the type of pass-rush profile that can create problems for backup quarterbacks.

The biggest factor before placing player props or larger parlays is confirmation of the quarterback rotation.

Preseason markets can change quickly when a coach announces a different playing-time plan.

Cardinals vs Packers Player Props

The Cardinals vs Packers player props require more caution than regular-season NFL props because playing time is often uncertain.

Kyle McCord Player Props

Kyle McCord is one of the more interesting Green Bay players to monitor.

He completed 12 of 19 passes for 118 yards against Denver last week while helping the Packers dominate a 33-13 road victory.

McCord doesn’t need to produce huge numbers for Green Bay to cover.

If he receives extended action Friday, his passing-yardage and completion props could become more appealing.

Carson Beck Player Props

Carson Beck’s availability is important.

He has been dealing with rib soreness, which makes his expected workload difficult to project.

If Beck is limited or unavailable, Arizona’s quarterback rotation becomes even more dependent on Kyle Trask and Gardner Minshew.

That would strengthen the case for Green Bay’s defense.

Gardner Minshew Player Props

Gardner Minshew brings substantially more NFL experience than some of Arizona’s other backup options.

That experience could help the Cardinals avoid offensive breakdowns.

However, playing behind an offense dealing with multiple skill-position injuries and facing a Packers defense at Lambeau makes his passing props difficult to trust without a confirmed workload.

Matt LaFleur vs Mike LaFleur

One of the most unusual elements of the Cardinals vs Packers Preseason Betting Prediction is the coaching matchup.

Matt LaFleur is entering his eighth season as Green Bay’s head coach.

Mike LaFleur is entering his first season as Arizona’s head coach.

The two are brothers.

Friday night represents their first matchup as opposing NFL head coaches.

Family competition should not be treated as a standalone handicapping system, but the storyline is relevant because Matt LaFleur has significantly more experience running an NFL organization.

Green Bay has a stable system.

Arizona is entering a transition period.

That distinction matters more in preseason football because backups are often being asked to execute systems without the same level of preparation or continuity as starters.

Green Bay’s familiarity with LaFleur’s system gives its depth players an advantage.

Green Bay’s Home-Field Advantage

Lambeau Field is a major component of the Cardinals vs Packers Preseason Betting Prediction.

This is Green Bay’s only home preseason game of 2026.

That means Friday night provides the team’s fans with their only opportunity to watch the Packers play at Lambeau during the preseason.

The atmosphere should be considerably stronger than a typical preseason road game.

More importantly, the Packers don’t have to deal with travel.

Arizona does.

That matters when evaluating two teams whose rosters will consist largely of players fighting for roster positions.

Young players and backups are more susceptible to communication issues.

Green Bay’s familiarity with the environment removes one potential source of mistakes.

Packers Preseason Performance

Green Bay enters Friday with momentum.

The Packers defeated Denver 33-13 in Week 2.

The performance was impressive on both sides of the football.

Green Bay outgained Denver 299-225, while Kyle McCord completed 12 of 19 passes for 118 yards.

The 20-point margin is also important.

Preseason results shouldn’t be treated like regular-season results, but large margins can reveal which teams have better depth.

Green Bay has now demonstrated that its second and third units can maintain a lead.

That is exactly what bettors want to see when backing a preseason underdog.

The Packers aren’t simply getting points because they’re playing at home.

They’re getting points despite coming off one of the more convincing performances of Week 2.

Cardinals Preseason Performance

Arizona enters the game from a much less favorable position.

The Cardinals were beaten 34-13 by Dallas in their most recent preseason game.

Arizona was outgained 413-325.

The Cardinals struggled to establish offensive consistency while their defense allowed Dallas to control the game.

That performance is particularly concerning when combined with the injuries now affecting Arizona’s roster.

A team already struggling to generate production doesn’t want to lose additional depth before the preseason finale.

Arizona is also playing on the road.

The combination of poor recent performance, injuries and a road environment creates a difficult setup for the Cardinals.

Arizona’s Injury Situation

The injury situation is one of the strongest reasons to consider Green Bay in the Cardinals vs Packers Preseason Betting Prediction.

Trey Benson has reverted to injured reserve with a knee injury.

James Conner has also been dealing with a foot issue.

Carson Beck has been limited with rib soreness.

Those injuries affect multiple areas of Arizona’s offense.

Running back depth becomes more important when backup quarterbacks are playing.

A limited running game can place additional pressure on quarterbacks to throw.

That is exactly the kind of situation that can create mistakes.

Arizona’s offensive depth therefore enters Friday with more questions than Green Bay’s.

Green Bay’s Defensive Matchup

Green Bay’s defense is another reason to prefer the home underdog.

The Packers have developed a reputation for generating pressure and defending high-leverage situations.

During the 2025 regular season, Green Bay recorded eight sacks in goal-to-go situations, the most in the NFL.

That ability to pressure opposing quarterbacks near the goal line is particularly useful against backup-heavy offenses.

Arizona’s quarterback group is going to have to operate against a defense that has already demonstrated an ability to disrupt drives.

If Green Bay can generate pressure early, the Cardinals could have difficulty scoring enough points to justify laying 2.5 points on the road.

The Packers don’t need a dominant defensive performance.

They simply need their defense to continue playing at the level it showed in Denver.

Cardinals vs Packers Follow-Up Questions

Who Is Favored in Cardinals vs Packers?

The Arizona Cardinals are 2.5-point road favorites over the Green Bay Packers.

What Is the Cardinals vs Packers Total?

The total is approximately 37.5 points.

Why Are the Cardinals Favored on the Road?

Arizona is favored because bookmakers generally rate the Cardinals’ overall roster higher, but the preseason setup creates additional value on Green Bay.

Are the Packers Playing at Lambeau Field?

Yes. Green Bay hosts Arizona at Lambeau Field.

Is This Green Bay’s Only Home Preseason Game?

Yes. Friday night’s game is the Packers’ only home preseason contest of 2026.

Who Is Matt LaFleur Playing?

Matt LaFleur faces his younger brother Mike LaFleur, Arizona’s first-year head coach.

How Did Green Bay Perform Last Week?

The Packers defeated Denver 33-13 on the road.

How Did Arizona Perform Last Week?

The Cardinals lost 34-13 to Dallas.

What Is the Best Cardinals vs Packers Bet?

The preferred wager is Green Bay Packers +2.5.

Is the Under Worth Betting?

There is a reasonable case for Under 37.5, particularly if both teams limit their starters and Arizona’s offensive injuries continue to affect its depth.

Cardinals vs Packers FAQ

1. Who will win Cardinals vs Packers?

The Green Bay Packers are the preferred side despite entering the game as 2.5-point home underdogs.

2. What is the Cardinals vs Packers Preseason Betting Prediction?

The Cardinals vs Packers Preseason Betting Prediction favors Green Bay +2.5 because the Packers have home-field advantage, stronger recent preseason momentum and a more stable roster situation.

3. What is the Cardinals vs Packers spread?

Arizona is currently favored by 2.5 points.

4. What is the Cardinals vs Packers over/under?

The total is approximately 37.5 points.

5. Who is favored between Arizona and Green Bay?

The Cardinals are the road favorite, laying 2.5 points.

6. Why are the Packers getting points at home?

Arizona is generally being rated as the stronger overall team, but the unusual road-favorite situation creates value on Green Bay in this specific preseason matchup.

7. Who is Green Bay’s backup quarterback?

Kyle McCord has handled significant preseason quarterback duties and played effectively in Green Bay’s Week 2 victory.

8. Is Carson Beck playing for Arizona?

Beck has been dealing with rib soreness, so his status and expected workload should be monitored before betting player props.

9. What happened in the Packers’ last preseason game?

Green Bay defeated Denver 33-13 and outgained the Broncos 299-225.

10. What is the best bet for Cardinals vs Packers?

The best bet is Green Bay Packers +2.5.

Final Cardinals vs Packers Preseason Betting Prediction

The Cardinals vs Packers Preseason Betting Prediction presents an unusual betting opportunity.

Arizona is a road favorite.

Green Bay is the home underdog.

Normally, that alone isn’t enough to make a wager.

But when the rest of the matchup is examined, the Packers have a compelling collection of advantages.

First, Green Bay is playing its only preseason game at Lambeau Field.

The atmosphere should be stronger than what the Packers have experienced in their previous preseason games, and the home team doesn’t have to deal with travel or unfamiliar surroundings.

Second, Green Bay is coming off a convincing victory.

The Packers beat Denver 33-13 last week, outgaining the Broncos 299-225.

Kyle McCord completed 12 of 19 passes for 118 yards, and Green Bay’s backup-heavy lineup was able to control the game.

Arizona had the opposite experience.

The Cardinals were beaten 34-13 by Dallas, giving up 413 total yards.

Now they head into the finale with additional questions surrounding their offensive personnel.

Trey Benson is headed to injured reserve with a knee injury.

James Conner has been dealing with a foot issue.

Carson Beck has been limited by rib soreness.

That’s a difficult combination for a team that is already going to rely heavily on backup players.

Then there is the coaching matchup.

Matt LaFleur faces Mike LaFleur.

The two brothers will meet as opposing NFL head coaches for the first time.

The emotional component shouldn’t be overstated, but Matt’s extensive experience running the Packers gives Green Bay a stability advantage over an Arizona organization beginning a new era.

The defensive matchup also favors the Packers.

Green Bay’s ability to create pressure in critical situations can become particularly valuable against backup quarterbacks.

Arizona’s quarterbacks will have to operate against a defense that has already demonstrated that it can disrupt drives.

The total of 37.5 deserves consideration as well.

Both teams are expected to rely heavily on backups, and Arizona’s offensive injuries could further suppress scoring.

Still, the side is the cleaner wager.

Green Bay doesn’t have to win outright.

The Packers simply need to stay within three points.

Considering the home-field advantage, the recent 33-13 victory, Arizona’s injuries and the Packers’ defensive profile, that is a very reasonable requirement.

The Pick: Green Bay Packers +2.5

Best Bet: Green Bay Packers +2.5

Secondary Bet: Under 37.5

Prediction: Green Bay keeps this game close throughout and has a legitimate opportunity to win outright at Lambeau Field.