Broncos vs Colts Prediction NFL Week 2 Predictions. Place a bet on this NFL football game with the best lines and bonuses at YouWager.lv.

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The Week 2 clash between the Denver Broncos and Indianapolis Colts offers one of the most intriguing betting matchups on the schedule.

Broncos vs Colts Prediction NFL Week 2 Predictions

My pick for the Colts vs. Broncos game is the Broncos Spread (-2.5, -115), based on Daniel Jones’ bad ATS record as a short underdog and the dismal historical record of dogs off a huge win.

Following a victory over a club as lackluster as the Dolphins, this is simply too much praise for the Indianapolis Colts.

The Indianapolis Colts gained immensely from turnovers in the first week. Seventeen of the thirty-three points scored by Indianapolis were the result of drives that began after a turnover committed by Miami.

Bo Nix experienced a great deal of misfortune in terms of turnovers during his match versus Tennessee. Nevertheless, his outstanding defense came to his rescue as Denver held Tennessee to a mere 2.4 yards per play.

As a result, gamblers are of the opinion that the best option for bettors is to sell their Indianapolis shares at a premium price. In the past, early underdogs that have pulled off a significant victory have demonstrated that they are likely to fade in the long run.

Since 2003, canines that have won by a margin of twenty-one or more points have an ATS record of 16-34-2 in games 2–4. When those dogs are valued at three or less, their record is 5-23-2 ATS.

Taking everything into account, Daniel Jones does not have the market viability required of a short market pup.

The Duke product started out his career in the National Football League with a record of 8–4 ATS at +3.5 or lower. Over the course of his last six starts within that range, he has accumulated a record of 0–6 ATS, with five of those losses being by a margin of 20 points or greater.

In the meantime, Nix has an ATS record of 8–1 when being the market favorite. In addition to this, Broncos head coach Sean Payton has a career record of 37-21-2 (63.8%) ATS between -3.5 and -1, including a record of 6-3-1 with Denver.

Taking into consideration those elements, I am a fan of the Broncos covering a low number in Week 2 to begin the season with a record of 2–0.

Broncos vs Colts Prediction NFL Week 2 Predictions: Head to Head

Date	Opponent	Score	Spread	Total	Moneyline
12/15/24	@DEN	DEN 31-13	DEN+2.5	U44.5	DEN+120
8/11/24	@IND	DEN 34-30	IND+2.5	O37.5	IND+110
10/06/22	@DEN	IND 12-9	DEN-3.5	U44	DEN-155
10/27/19	@IND	IND 15-13	IND-4.5	U42	IND-235
12/14/17	@IND	DEN 25-13	NL	NL	NL
9/18/16	@DEN	DEN 34-20	NL	NL	NL
11/08/15	@IND	IND 27-24	NL	NL	NL
1/11/15	@DEN	IND 24-13	NL	NL	NL
9/07/14	@DEN	DEN 31-24	NL	NL	NL
10/20/13	@IND	IND 39-33	NL	NL	NL

Broncos vs Colts Prediction NFL Week 2 Predictions: Team Previews

The head-to-head matchup history between these franchises is another important angle to consider. Denver has beaten Indianapolis convincingly in two straight meetings, including a 31-13 win last December. While the Colts do own a strong 7–1 home record against Denver since 2003, the current circumstances tilt the edge toward the Broncos. The combination of Nix’s control of the offense, Payton’s coaching edge, and Indianapolis’ likely regression from turnover luck positions Denver as the better bet in Week 2. This game is set up as a “prove-it” spot for the Colts, but all signs point to Denver starting the season 2–0 both straight up and against the spread.

Broncos vs Colts Prediction NFL Week 2 Predictions: Denver

Now in this Broncos vs Colts Prediction NFL Week 2 Predictions, we have the Denver betting preview.

Denver is coming off a gritty win over Tennessee, where their defense dominated and Bo Nix showed resilience despite turnovers. The Broncos’ ability to limit mistakes and lean on Sean Payton’s strong track record against the spread as a small favorite makes them a strong candidate to cover once again. With Nix holding an 8–1 ATS record as a favorite, this team is trending upward, and bettors are taking notice.

Broncos vs Colts Prediction NFL Week 2 Predictions: Denver Trends

Next in this Broncos vs Colts Prediction NFL Week 2 Predictions, we have the Denver trends:

• The current record of Denver is 1–4 against the spread in their previous five games.
• In its previous nine games, Denver has a record of 6–3 SU.
• Over the course of their last five matches, Denver has maintained an average of four wins and one loss.
• Over the course of its last fourteen games versus Indianapolis, Denver has a record of 4–10 straight up.
• In their last six away games, Denver has only won one game, finishing with an SU record of 1-5.
• When Denver plays at Indianapolis, they have a record of 1–7 SU in their last eight road games.
• Over the course of its last six matchups against a team in the American Football Conference conference, Denver has a 2-4 ATS record.
• The total has gone UNDER in eight of the last nine matchups between Denver and a team in the American Football Conference South division.
• In twelve of the fifteen games that Denver has played in the month of September, the total has ended up being below expectations.

Denver Last 10 Games

Date	Opponent	Score	Spread	Total	Moneyline
9/07/25	TEN	W 20-12	W-7.0	U40.5	W-360
1/12/25	@BUF	L 31-7	L+8.5	U47.5	L+340
1/05/25	KC	W 38-0	W+4.0	U46.5	W+160
12/28/24	@CIN	L 30-24	W+7.5	O45.5	L+280
12/19/24	@LAC	L 34-27	L+3.5	O45	L+150
12/15/24	IND	W 31-13	W+2.5	U44.5	W+120
12/02/24	CLE	W 41-32	W+3.5	O43	W+150
11/24/24	@LV	W 29-19	W+3.0	O42	W+130
11/17/24	ATL	W 38-6	W+3.0	U44.5	W+142
11/10/24	@KC	L 16-14	W+9.0	U46	L+320

Broncos vs Colts Prediction NFL Week 2 Predictions: Indianapolis

Now in this Broncos vs Colts Prediction NFL Week 2 Predictions, we have the Indianapolis betting preview.

Indianapolis enters this game with plenty of questions despite their blowout win over Miami. That victory was heavily influenced by turnovers, as 17 of their 33 points came off short-field opportunities. Daniel Jones’ struggles ATS as a small underdog are well documented, with an 0–6 mark in his last six starts in this spot. Historically, underdogs coming off a huge win of 21+ points fade quickly in subsequent games, and Indianapolis may fall victim to that pattern. Their defense also showed vulnerabilities late last season, giving up 30 or more points multiple times, and that could resurface against a balanced Broncos offense.

Broncos vs Colts Prediction NFL Week 2 Predictions: Indianapolis Trends

Next in this Broncos vs Colts Prediction NFL Week 2 Predictions, we have the Indianapolis trends:

• Over the course of its most recent seven games, Indianapolis has compiled a record of 2–5 against the spread.
• In the last nine games played by Indianapolis, the total has gone over six times.
• The Indianapolis team has a record of 4 wins and 2 losses over its most recent six games.
• The score of Indianapolis has been 6–2 SU in its last eight home games.
• In the last eight games that Denver has played versus Indianapolis in Indianapolis’ home venue, Indianapolis has a record of 7 wins and 1 loss.
• The total has gone OVER in five of the seven most recent games that Indianapolis has played against a team in the American Football league league.
• In the past seven games that Indianapolis has played in September, they have a record of 6–1 ATS.
• In the past eight games that Indianapolis has played in week two, they have had an ATS record of 6–2.
• In twelve of the seventeen games that Indianapolis has played on Sundays at home, the overall number of points scored has exceeded expectations.

Indianapolis Last 10 Games

Date	Opponent	Score	Spread	Total	Moneyline
9/07/25	MIA	W 33-8	W-1.5	U45.5	W-116
1/05/25	JAC	W 26-23	W-1.5	O46.5	W-122
12/29/24	@NYG	L 45-33	L-2.0	O43.5	L-130
12/22/24	TEN	W 38-30	W-3.5	O44.5	W-175
12/15/24	@DEN	L 31-13	L-2.5	U44.5	L-142
12/01/24	@NE	W 25-24	L-2.0	O44	W-125
11/24/24	DET	L 24-6	L+2.5	U47.5	L+114
11/17/24	@NYJ	W 28-27	W+4.0	O46	W+160
11/10/24	BUF	L 30-20	L+2.0	O46.5	L+105
11/03/24	@MIN	L 21-13	L+1.0	U46.5	L-110

 

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