Cardinals vs Saints Betting NFL Predictions Week 1 2025 Sunday Night Football. Place a bet on this NFL football game with the best NFL Week 1 betting lines.

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Cardinals vs Saints Betting NFL Predictions Week 1 2025

The Arizona Cardinals and New Orleans Saints will headline Week 1 Sunday Night Football in 2025, and bettors already have their eyes on the numbers.

Cardinals vs Saints Betting NFL Predictions Week 1 2025: Head to Head

NFL Week 1 Betting Lines: Cardinals vs Saints Odds

Now in these Cardinals vs Saints Betting NFL Predictions Week 1 2025, we have the game odds:

Cardinals vs Saints Betting NFL Predictions: Week 1 NFL Spreads 2025

Now in these Cardinals vs Saints Betting NFL Predictions, we have the Week 1 NFL Spreads 2025:

TEAM	SPREAD
Arizona	-6.5
NOLA	+6.5

Cardinals vs Saints Betting NFL Predictions Week 1 2025: Moneyline

Now in these Cardinals vs Saints Betting NFL Predictions, we have the moneyline:

TEAM	MONEYLINE
Arizona	-270
NOLA	+225

Cardinals vs Saints Betting NFL Predictions Week 1 2025: Over Under

Now in these Cardinals vs Saints Betting NFL Predictions, we have the Week 1 Over Under:

OVER / UNDER
42.5 O
42.5 U

Cardinals vs Saints Betting NFL Predictions Week 1 2025: Team Previews

Arizona opens as a -6.5 favorite with a -270 moneyline, while the Saints sit at +225. The total is set at 42.5, giving bettors the choice between two teams with very different trends. Arizona has been an over team lately, while New Orleans has leaned under in most of their recent contests. With the spotlight on these two NFC foes, sportsbooks are bracing for big action on both sides.

Cardinals vs Saints Betting NFL Predictions: Arizona 2025 NFL Betting Preview

Now in these Cardinals vs Saints Betting NFL Predictions, we have the Arizona 2025 NFL Betting Preview.

Arizona comes into the matchup with positive betting momentum. The Cardinals are 8-3 against the spread in their last 11 games, including multiple outright upsets late last season. Their offense is powered by one of the NFL’s most efficient rushing attacks, averaging over 144 yards per game. That balance will test a Saints defense that ranked 30th against the run in 2024. While Arizona has historically struggled when traveling to New Orleans, this roster has the depth and offensive rhythm to challenge those trends. If the Cardinals can limit turnovers, they are set up well for a comfortable win.

Cardinals vs Saints Betting NFL Predictions: Arizona Trends

Next in these Cardinals vs Saints Betting NFL Predictions, we have the Arizona trends:

• Over the past 11 games, Arizona has a record of 8-3 against the spread.
• Each of Arizona’s most recent five games has resulted in the total going over.
• In its last seven games, Arizona has a winning percentage of 2-5.
• The Arizona Cardinals have a record of 4-8 against New Orleans in their last 12 games.
• In its last 20 games played away from home, Arizona has a record of 4-16 against the spread.
• When Arizona has played New Orleans on the road, the team has a record of 0-5 against the spread in its last five games.
• The Arizona Wildcats have a head-to-head record of 1-4 in their previous five meetings against teams from the National Football Conference.
• Over the course of its last six games against teams from the National Football Conference South division, Arizona has a record of 5-1 against the spread.
• In the last six games that Arizona has played in September, the total has been over in five of those games.

Arizona Last 10 Games

Date	Opponent	Score	Spread	Total	Moneyline
1/05/25	SF	W 47-24	W+5.5	O43	W+190
12/28/24	@LAR	L 13-9	W+5.5	U48.5	L+195
12/22/24	@CAR	L 36-30	L-1.0	O45.5	L-118
12/15/24	NE	W 30-17	W-3.0	O44	W-155
12/08/24	SEA	L 30-18	L-1.0	O47.5	L-112
12/01/24	@MIN	L 23-22	W+1.5	U45.5	LEVEN
11/24/24	@SEA	L 16-6	L-1.0	U45.5	L-115
11/10/24	NYJ	W 31-6	W+3.0	U46.5	W+130
11/03/24	CHI	W 29-9	W+1.0	U46.5	W-108
10/27/24	@MIA	W 28-27	W+6.0	O47	W+200

Arizona Cardinals Sportsbook Cash Bonuses

When it comes to betting on the Arizona Cardinals, taking advantage of sportsbook bonuses can give you a strong edge. The Cardinals have shown they can surprise bettors with big performances, especially when their rushing game is dominant. Pairing your wager on Arizona with a 100% crypto sign-up bonus from YouWager means doubling your bankroll before the action even kicks off. If you’re backing the Cardinals as favorites in Week 1, boosting your initial deposit ensures you have more flexibility to play the spread, moneyline, and totals. YouWager’s bonuses make every Cardinals bet that much stronger.

Cardinals vs Saints Betting NFL Predictions: NOLA 2025 NFL Betting Preview

Now in these Cardinals vs Saints Betting NFL Predictions, we have the NOLA 2025 NFL Betting Preview.

For the Saints, this game represents both a challenge and an opportunity. Despite ending the 2024 season with multiple losses, New Orleans has a perfect 6-0 record in Week 1 games. They have also been dominant at home against Arizona, covering in five straight meetings. With betting odds stacked against them, the Saints’ value comes in their ability to cover the spread and potentially steal a low-scoring upset. Given their defensive struggles, the key will be whether the offense can keep pace. Bettors looking for plus-money value will be tempted by New Orleans’ history in early-season matchups.

Cardinals vs Saints Betting NFL Predictions: NOLA Trends

Next in these Cardinals vs Saints Betting NFL Predictions, we have the NOLA trends:

• The over/under record for New Orleans’s last 13 games is 4-9.
• Over the past six games, the total has been under in five of New Orleans’ games.
• Over the course of its last six games, New Orleans has a winning percentage of 1-5.
• Seven of the nine games that New Orleans has played versus Arizona have resulted in the total going over.
• Four of New Orleans’ most recent five games played at home have resulted in the total going UNDER.
• When playing at home versus Arizona, New Orleans has a perfect record against the spread in its last five games.
• During the last five games that New Orleans has played against teams from the National Football Conference, the total has been under in four of those games.
• In its last five games against teams from the National Football Conference West division, New Orleans has struggled to a record of 1-4 against the spread.
• With a perfect 6-0 record, New Orleans has won all six of its games played in week 1.
• In its last five games played on Sundays, New Orleans has a record of 1-4 straight up.

NOLA Last 10 Games

Date	Opponent	Score	Spread	Total	Moneyline
1/05/25	@TB	L 27-19	L+2.5	O43	L+114
12/29/24	LV	L 25-10	L-2.0	U43	L-130
12/23/24	@GB	L 34-0	L+5.0	U45	L+180
12/15/24	WAS	L 20-19	L-2.5	U42	L-142
12/08/24	@NYG	W 14-11	W-0.5	U41	W-112
12/01/24	LAR	L 21-14	L+1.5	U46.5	L+102
11/17/24	CLE	W 35-14	W+2.0	O42	W+110
11/10/24	ATL	W 20-17	W+1.5	U44.5	W+105
11/03/24	@CAR	L 23-22	L-1.0	O40.5	L-118
10/27/24	@LAC	L 26-8	L+3.0	U44	L+130

New Orleans Saints Sports Betting Cash Bonuses

For New Orleans Saints fans and bettors, the value is in the underdog role. The Saints’ ability to cover at home against Arizona makes them an attractive bet, especially with a juicy +225 moneyline. Adding in a 100% crypto sign-up bonus from YouWager gives bettors the perfect chance to maximize that underdog potential. Doubling your bankroll lets you spread wagers across moneyline, point spread, and totals, giving more options to profit. Saints bettors know that Week 1 has historically been kind to their team, and with YouWager’s cash bonuses, that tradition can become even more profitable.

Week 1 Betting Guide: NFL Best Bets

Now, in addition to these Cardinals vs Saints Betting NFL Predictions, we have general Week 1 betting picks:

Cardinals vs Saints Betting NFL Predictions: Additional Week 1 Key Matchups to Watch

There is a slate of games that will influence the overall course of the season, and they will all take place during the first week of the season. There are a few competitions that stand out from the rest due to the fact that they either have competitive spreads, enormous totals, or fascinating tales.

• There will be a matchup between the Philadelphia Eagles, who are the current champions of the Super Bowl, and the Dallas Cowboys in the first game of the season. With a seven-point advantage over their NFC East rivals, the Eagles are the favorites. With the moneyline currently resting at Eagles -310 and Cowboys +250, there are a total of 46.5 points that are available for wagering. Dallas may be able to keep the game close with their reconstructed defense, despite the fact that Philadelphia is a massive favorite owing to the fact that they have a dominant team and will be playing at home.
• There, the Baltimore Ravens are playing in Buffalo Bills Stadium. This Sunday night battle has a total of 51.5 points, giving it the highest total of the week when compared to other matches. On the other hand, Buffalo is a small 1.5-point favorite at home (the moneyline is -115), while the Ravens are now sitting at +105. Lamar Jackson and Josh Allen are the two players that are responsible for the potent offenses that both clubs have put together. The high-scoring expectations that we have for this game will it be able to live up to those expectations?
• This is a game between the Green Bay Packers and the Detroit Lions: In this game, the spread is pretty narrow, with Detroit being favored by 1.5 points (-115 moneyline) and a total of 49.5 points across the board. The game is being played between two teams. This game is a great example of a clash between two teams from the NFC North. On both teams, there is a lineup that is considered to be young and talented. A home-field advantage for Green Bay at Lambeau Field could be the determining factor in this contest. Lambeau Field is located in Green Bay.
• The New York Giants are now competing at Washington Commanders: The moneyline for the game was -400, and Washington was a 7.5-point favorite over the Giants (+300). The Giants were the underdog when the game began. With this, the total number of points is now 45.5. In the event that Jayden Daniels is leading a powerful offensive attack for the Commanders, the question arises as to whether or not the Giants’ defense will be able to stand up when played away from home.

Week 1 NFL Best Bets: Underdog Opportunities

In the first week of the season, when teams are either getting over their initial rust or exceeding expectations, it is not uncommon for them to surprise their opponents. When you make your selections, betting on the underdogs might be rewarding if you carry out the process in the right way. Taking into consideration the following underdogs is something you should do.

• As a result of the fact that the line for the game between the Carolina Panthers (+140) and the Jacksonville Jaguars has changed from Jaguars -3.5 to -2.5, it is clear that gamblers are still hunting for value in the Carolina Panthers. In the event that Bryce Young’s late-season surge in 2024 persists, the Panthers are a significant underdog because it is probable that it will carry over into the following season.
• The Kansas City Chiefs will be facing the Los Angeles Chargers (+130). It is possible that Justin Herbert and a revived Chargers roster under Jim Harbaugh will make this game a close fight. The Chiefs are the favorites in Brazil by a margin of 2.5 points; yet, this game might be considered a close contest.
• Take a look at the next matchup between the Chicago Bears and the Minnesota Vikings (+102): The Minnesota Vikings are a sneaky bet to steal a road win because of their stronger offensive line and the potential of J.J. McCarthy. This is despite the fact that Chicago has a spread of -1.5, which indicates that they are at a disadvantage.

During the first week of the season, underdogs frequently emerge victorious due to the unpredictability of the team’s features. Are you willing to risk your money on one of these teams despite the fact that they have a poor track record?

Week 1 Over Under NFL Totals to Target

Betting on the game totals can be a logical approach to avoid picking a side when you want to avoid picking a side. The over/under lines for Week 1 are fairly intriguing, and they are based on the offensive and defensive matchups that are featured in the various games.

• Due to the fact that both the Ravens and the Bills have strong offenses, the game between the two teams has the highest total, which is 51.5. Both of the games that took place between these two clubs in the previous year finished with a total of 45 points scored. In the event that the defenses start off slowly, the over appears to be an appealing financial option.
• This number has the ability to climb fairly quickly owing to the fact that both the Lions and the Packers have playmakers who are dynamic and secondaries that are problematic. This statistic has the potential to increase rather quickly. In the beginning of the game, will the offensive team seize the lead?
• Jared Verse is leading a formidable pass rush for the Rams, which Houston’s “revamped” offensive line is going to have to cope with. The Texans will take on the Rams, who have a 46.5 point spread. There is a possibility that the under will be more advantageous in a game with fewer points scored.

Best Sunday Night Football Prop Bets

When it comes to gambling on games that are presently taking place during Week 1, player props give an additional level of excitement to the game that is currently taking place within the context of the wagering. You should keep an eye out for the following early viewpoints, despite the fact that there are some things that are not yet totally accessible to you. The following are some of the things that you should keep an eye out for.

• Given that Buffalo had a difficult time battling against mobile quarterbacks during the previous season, it is feasible that the prop for Lamar Jackson’s (Ravens) running yards can be regarded a good over bet. This is because of the fact that the Ravens had a lot of trouble competing against mobile quarterbacks.
• Saquon Barkley (Eagles) is the focal point of Philadelphia’s offense; nonetheless, it is likely that Barkley’s total yards or rushing attempts for the Eagles will be a sure bet against Dallas.
• This is because Barkley is the most important player for the Eagles. The reason for this is that Barkley is the prime target of the onslaught that Philadelphia is launching. The reason for this is that Philadelphia is focusing their assault mostly on Barkley, who is the major target of their assault.
• Davante Adams, who plays opposite Puka Nacua for the Rams, will make the receiving yards prop more entertaining. This is because Adams will be playing against Nacua. Puka Nacua is likely to have a reduction in the amount of coverage. As far as the Rams are concerned, Puka Nacua is a member of the team.

Due to the fact that prop markets will open their doors closer to the season, it is extremely necessary to keep a close eye on them. Because of this, it is of the utmost importance to keep a close eye on them. Which players do you believe will have a strong performance in the opening week of the season, according to your own opinion? What are some of the players that you think will have a strong performance?

Factors That Could Shift the Lines

There are a variety of circumstances that might cause betting lines to change, and these changes can be substantial. Prior to placing your bets, there are a few things that you should remain vigilant about.

• In the event that their status changes, major players like Christian Darrisaw (Vikings) and Jalen Ramsey (Dolphins) might potentially have an impact on spreads. This is because of the injuries that they have now sustained.
• The Roster Moves: There is the possibility that trades or signings will affect the lines in a significant way.
• Placements made by members of the general public: Spreads may expand as a result of significant wagers placed on favorites like the Eagles or the Commanders, which presents an opportunity for underdogs to gain value.
• Ben Johnson, who coaches the Bears, and Liam Coen, who coaches the Jaguars, are two instances of rookie coaches that have the ability to contribute to unexpected team performances at the beginning of the season.

Cardinals vs Saints Betting NFL Predictions: Best NFL Survivor Football Picks Week 1

Now in these Cardinals vs Saints Betting NFL Predictions, we have the best Week 1 NFL survivor pool picks:

As opposed to the Tennessee Titans, the Denver Broncos (-7.5)

The first official pick from the survivor pool will be the Denver Broncos. During the first week, they are the most anticipated team, and for good reason. Tennessee has problems on both sides of the ball, and they did not receive sufficient reinforcements during the offseason to improve their chances of competing against a squad like Denver. This Broncos team has serious dreams of winning the Super Bowl, and the most important thing for them to do is to stop Cam Ward, who is a rookie quarterback. In the first game of his second season, Bo Nix will look absolutely amazing, and it is inconceivable that the Broncos might lose at home any time soon. In spite of the fact that this is going to be a square and a popular choice this week, there are times when it is just the way to go. Because there are still one hundred percent of entries that are still alive, we have plenty of time to diverge from the common technique, and there is no reason to get nice.

The Washington Commanders have a 6.5 point advantage over the New York Giants.

There is absolutely no way that the New York Giants could defeat the Washington Commanders in Week 1. Divisional matchups are typically a wise thing to avoid in survivor pools. Jayden Daniels made a name for himself for Washington in the previous season, and the team that he is a part of is even more accomplished than it was in the previous year. It is possible that the Commanders will not be able to recreate the incredible season that they had the previous year, but they will be able to begin the season with a victory that will make them feel good in front of their home fans.

The Arizona Cardinals defeated the New Orleans Saints by a score of -6.

This season, one of the most common strategies will be to bet against the New Orleans Saints, and even a team that is not particularly good, such as the Cardinals, can make this look like an easy bet. It has been a long time since Kyler Murray has had a breakout season, and it is possible that it will never happen. Although Murray has not lived up to the expectations that were placed on him, both Tyler Shough and Spencer Rattler have appeared to be terrible. In addition to having a lack of youthful potential, the Saints are struggling financially, and it is possible that they will finish the season with a record of 0-17. This is not a bad pick if you want to avoid the Broncos because Arizona does not have a lot of games on its schedule that are easier than this one.

A victory for the Kansas City Chiefs (-3) over the Los Angeles Chargers

Even though the Kansas City Chiefs were humiliated in the Super Bowl during the previous season, Patrick Mahomes and his team will not let that deter them from completely destroying the Los Angeles Chargers. There is always the possibility that the international twist will throw a curveball into this clash; but, the Chiefs have had the Chargers over their heads in recent seasons. Nevertheless, utilizing the Chiefs in Week 1 is not a prudent approach because there are other options available that are safer.

The New England Patriots have a three-point advantage over the Las Vegas Raiders.

In this game, there are a lot of reasons to be optimistic about the Patriots. It is possible that it will take some time for Geno Smith to adjust to a new offense as Drake Maye has been doing better each time he has taken the field. In addition to this, the Patriots’ defensive advantages will make the shift even more difficult to make. As a result of the fact that this will be a low-scoring game of inches, New England will have a significant advantage in the game. Take the Patriots to win the game because they are the pick of the week that goes against the conventional wisdom. If you want to shake things up in Week 1, they are the team to go with.

The Indianapolis Colts defeated the Miami Dolphins by a score of -2.

Surprisingly, the Indianapolis Colts are going to start Daniel Jones in the first week of the season. Jones is a dependable starter in the National Football League, and Anthony Richardson is still a gifted young player, despite the fact that this is a contentious move with the future in mind. There are significant problems on both sides of the ball, in the locker room, and pretty much everywhere else in the Dolphins’ organization at the moment. These problems are affecting the Dolphins across the entire field. The Colts are marginally better in every position, and it will be sufficient for the victory at home. A positive outcome from Week 1 would be enough to elevate those spirits, but the Colts play better overall.

A victory for the Philadelphia Eagles (-7) over the Dallas Cowboys

The best course of action to avoid during this week is to avoid this. Against a Cowboys team that is hungry for victory, the Eagles are going to be in for a Super Bowl hangover. This season, Dallas will be significantly better than the majority of people believe they will be, and a victory against the team that is currently in the championship would not surprise me in the least. On account of the fact that the Cowboys are one of the few teams that are capable of matching the Eagles’ level of physicality, this game will be much closer to a tie than the spread indicates it would be. Having said that, the Eagles continue to be an exceedingly dominant club and will most likely find a way to accomplish what they set out to do.

Over the New York Jets, the Pittsburgh Steelers (-3) Victory

With the Steelers, how will Aaron Rodgers appear to the public? I anticipate that the future Hall of Famer will get off to a stronger start than he did in his debut game with the Jets two years ago so that he may flourish. He has the defense that he needs to prosper. The only option available to New York is to use quarterback Justin Fields, who will appear to be helpless when facing a formidable defense like that of the Steelers.

Better than the Minnesota Vikings, the Chicago Bears (+1.5)

Monday night marks the conclusion of Week 1 for both the Bears and the Vikings, and Chicago is an excellent option to target throughout this week. After spending a year on the bench, Minnesota is unsure of what they can expect from JJ McCarthy, and Caleb Williams performed admirably in primetime games during the previous season. Over the course of the offseason, Chicago made a number of adjustments on both sides of the ball, and the Vikings will face significant challenges as a result of their strengthened defense. Even if there are more secure options available, I wouldn’t be surprised if you decided to go with the Bears this week.

Over the Cleveland Browns, the Cincinnati Bengals (-5.5) victory

Even though divisional games come with their own set of challenges, those challenges are compounded when they are played against a club like the Browns. On the other hand, Joe Burrow and the Bengals are running out of time to generate outcomes that can be measured, while Cleveland is not under any pressure to start the season. It is never an easy chore to play a road game against the muscular Browns, and Cleveland will definitely make this a filthy and slow game in the trenches when they play. What are the Bengals’ chances of winning the game? Indeed. Will I be placing my life in the survivor pool on their shoulders? Without a doubt not.

The Los Angeles Rams have a -2.5 advantage over the Houston Texans.

The fact that both of these clubs are considered to be underdogs this year means that this game will have significant significance for the playoffs at an early stage in the season. In spite of the fact that CJ Stroud is likely to recover from the sophomore slump he experienced the previous year, it is impossible to ignore Matthew Stafford and the Rams’ determined team. After retooling an already powerful offensive to become even more effective, the Rams are now capable of comfortably scoring 30 or more points at home.

A victory for the Atlanta Falcons (+1.5) over the Tampa Bay Buccaneers

Atlanta will be able to win this divisional clash in Georgia because they will have the advantage of playing at home, and they will be able to will their way to victory. There is no shortage of offensive skill to choose from in Tampa Bay; nevertheless, the team’s lack of run stoppers will provide Bijan Robinson with many opportunities to thrive. If the Falcons are able to find a way to take the lead thanks to Michael Penix Jr., then this will be the game that they will lose in the second half of the game.

A -1.5 advantage for the Green Bay Packers over the Detroit Lions

In the event that this matchup took place later in the year, we would most likely be taking the Lions. Despite the fact that Detroit has a greater advantage in terms of on-field skills, there is a possibility that there will be some misunderstandings with the new coaching staff. Green Bay boasts a significantly higher level of continuity from the previous season compared to the Lions, and they will be playing at the intimidating Lambeau Field. Although there is a slight bias for the Packers, it is usually best to avoid this team.

As opposed to the San Francisco 49ers, the Seattle Seahawks (+2.5)

The Seahawks made the decision to trade Geno Smith in order to make room for Sam Darnold, and this decision will prove to be profitable during the first week of the season. It is difficult to bet against the 49ers at any time throughout the season; nevertheless, this is a team that finished the previous season with seven of their eight games being losses. At this point, they are not even close to being healthy, and they are also dealing with suspensions. Additionally, the Seahawks have the advantage of playing at home in this contest, and they have a challenging schedule to contend with this season.

A victory for the Jacksonville Jaguars (-3) over the Carolina Panthers

If you are a survivor of the pool, you should not put your life in danger by participating in any of these dumpster fires at this point in the season. Now is not the time to put your faith in any of these cats; however, later on in the season, one of them might become a semi-reliable alternative.

Buffalo Bills Lose to Baltimore Ravens by a score of one.

The fact that these two teams are among the best in the league makes it impossible to even consider them in a matchup that is as close as this one. Be sure to familiarize yourself with the rules of the survivor pool if you want to take either side during Week 1.

 

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