Chargers vs 49ers Preseason Betting Prediction Week 3 August 23. Place a bet on this NFL football game with the best odds.

Visit our California Betting pages for more information

Chargers vs 49ers Preseason Betting Prediction

The Chargers and 49ers renew their preseason rivalry in Week 3, and this matchup comes with intriguing betting angles. From a betting perspective, this game lines up as a battle between a Chargers team that thrives in preseason betting situations and a 49ers team that has been inconsistent but carries strong defensive metrics. The total could be especially worth watching—Los Angeles leans toward overs, while San Francisco trends toward unders, creating a clash of styles. If the Chargers’ efficient offense and low-turnover rate hold up, they could once again take advantage of San Francisco’s shaky home spread record. On the flip side, if the 49ers’ defense plays to its ranking and their Saturday success continues, bettors backing San Francisco could cash in. This game is a classic preseason betting puzzle—Chargers backers have history and momentum on their side, but the 49ers bring the defensive edge and situational strength that could swing the outcome.

Chargers vs 49ers Preseason Betting Prediction: Head to Head

Chargers vs 49ers Preseason Betting Prediction: Los Angeles

Los Angeles has been one of the strongest teams against the spread, holding an impressive 11-4 mark in their last 15 games. They’ve also shown a clear tendency for overs, with all of their last eight games sailing past the point total. That type of betting consistency is rare in the preseason, where rotations and depth usually create volatility. Against the 49ers specifically, the Chargers have had the upper hand, winning five of the last six meetings, which only strengthens their betting value heading into this contest.

Chargers vs 49ers Preseason Betting Prediction: Los Angeles Trends

• Over the past 15 games, the Los Angeles Chargers have a record of 11-4 against the spread.
• In eight of the last eight games played by the Los Angeles Chargers, the total has been higher than the point spread.
• In their last seven games, the Los Angeles Chargers have a winning percentage of 5-2.
• The Los Angeles Chargers have a record of 5-1 against San Francisco in their last six games.
• In their last six games versus San Francisco, the Los Angeles Chargers have a winning record of 4-2 on the road.
• Five of the last six games that the Los Angeles Chargers have played away from home have resulted with the total going over.
• On the road versus San Francisco, the Los Angeles Chargers have a record of 6-1 against the spread in their last seven games.
• Four out of the previous five games that the Los Angeles Chargers have played against teams that are members of the National Football Conference have resulted in the total going over.
• In their last five games against teams from the National Football Conference West division, the Los Angeles Chargers have a record of 1-4 against the spread.
• The Los Angeles Chargers have a winning percentage of 4-9 in their last 13 games.

Chargers vs 49ers Preseason Betting Prediction: San Francisco

San Francisco, on the other hand, has been far less predictable. While their defense continues to rank among the league’s best in certain statistical categories—particularly against the pass—their recent preseason form has been shaky. The 49ers are just 1-4 against the spread in their last five home games, and they’ve struggled against AFC competition as well, posting a 1-4 record in their last five interconference matchups. Even at home against the Chargers, they’ve been unreliable, going just 1-6 ATS in their last seven meetings. Despite that, San Francisco’s strong track record on Saturdays, with a 12-3 record in their last 15 such games, adds an interesting wrinkle for bettors.

Chargers vs 49ers Preseason Betting Prediction: San Francisco Trends

• The over/under record for San Francisco’s previous six games is 1-5.
• Five of San Francisco’s most recent five games have resulted in the total going over.
• After six games, San Francisco has a record of 1-5 on the road.
• In its previous five games played at home, San Francisco has a record of 1-4 against the spread.
• During its last seven home games against the Los Angeles Chargers, San Francisco has a record of 1-6 against the spread.
• In the last five games that San Francisco has played against an opponent in the American Football Conference, the team has a record of 1-4 on the season.
• San Francisco’s last five games against teams from the American Football Conference West division have all resulted in the total going over in four of those games.
• The San Francisco 49ers have a winning record of 12-3 on Saturdays in their previous 15 games played.
• When San Francisco has played a game at home on a Saturday, the total has gone over in four of the last five games that they have played.

 

Read the NFL Betting Frequently Asked Questions. Visit the Betting School and learn how to wager on the moneyline, spread, and total; on your favorite team or an undervalued underdog. Sign up with YouWager.lv now and get in the game with the best welcome bonus, click below: