Buffalo Bills vs Cleveland Browns Prediction and Pick, Week 16, NFL Betting Picks

Buffalo Bills vs Cleveland Browns Prediction and Pick, Week 16, NFL Betting Picks. Place a bet on this game with the best odds.

Buffalo Bills vs Cleveland Browns Prediction – NFL Betting Picks

Now we have the Buffalo Bills vs Cleveland Browns Prediction for both teams.

This season, the Cleveland Browns have a record of 3-11 and are currently in fourth place in the American Football Conference North. They have a record of 2-5 at home and 1-6 away, with an overall record of 5-9 against the spread and 7-7 in the over/under. After suffering a defeat at the hands of the Chicago Bears by a score of 331 on the road, the Browns will now move on to play the Steelers and the Bengals.

On offense, the Browns score 16.1 points per game, which places them in the 29th spot in the National Football League. On defense, they allow 23.7 points per game, which places them in the 19th spot. This results in Cleveland allowing 279.1 total yards per game (110.1 rushing and 169 passing) while allowing 264.3 total yards per game (171.9 passing and 92.4 rushing) on average.

Shedeur Sanders is the all-time leader for the Browns in throwing yards with 946, with a completion percentage of 52.2% and five touchdowns. Harold Fannin has a team-high 66 receptions, 667 receiving yards, and four touchdowns, while Quinshon Judkins leads the team in running yards with 805 and Harold Fannin has the longest touchdown streak with four. Carson Schwesinger has a team-high 133 total tackles, 59 of which have been solo, while Myles Garrett has the most sacks of any player on the team with 21.5.

This year, the Buffalo Bills have a record of 10-4 and are currently in second place in the American Football Conference East. They are 7-7 against the spread, 7-7 in the over/under odds, and have a record of 6-1 at home and 4-3 away from home. The Bills are coming off a victory on the road against the New England Patriots by a score of 35-31, and their next opponents are the Eagles and the Jets.

On offense, the Bills score 29.4 points per game, which places them in third place in the National Football League. On defense, they allow 23.1 points per game, which places them in sixteenth place. There are a total of 312.6 total yards allowed per game by Buffalo, with 143.1 rushing yards and 169.5 passing yards. Buffalo’s average total yards per game is 381.2, with 222.7 passing yards and 158.5 rushing yards.

The Buffalo Bills are led by Josh Allen, who has thrown for 3276 yards, completed 70 percent of his passes, and scored 25 touchdowns. Khalil Shakir has a team-high 62 receptions, 650 receiving yards, and four touchdowns, while James Cook leads the team in rushing yards with 1415. Khalil Shakir also now leads the team in receiving yards. On the defensive side of the ball, Cole Bishop has a team-high 76 total tackles (46 of which were solo), Joey Bosa leads the team in sacks with five, and Cole Bishop, Christian Benford, Maxwell Hairston, and A.J. Epenesa each have two interceptions.

When it comes to this Bills vs. Browns prediction, the Bills are coming in as outright favorites on the road by ten points. The Bills have been the superior club during the course of this season, as they have accumulated ten victories, while the Browns have only three. However, the Browns are heading into this battle in strong form, with three consecutive victories, but on the other hand, the Browns have a record of 1-6 in their previous seven games and a record of 2-5 against the spread. They have also won four games away from home, while the Browns have only won two games at home. Given that the Bills have the third-best offensive in the league and that they are going up against the fourth-worst offense in the league, I anticipate that they will easily be able to accomplish their goal on the road today. You should take the Bills and put the ten on the road there.

✅ Our Buffalo Bills vs Cleveland Browns Pick: BILLS -10

Buffalo Bills vs Cleveland Browns Trends

In its last five games, Buffalo has a winning record of 4-1 against the spread.
The over/under record for Buffalo’s last seven games versus Cleveland is 5-1-1.
Buffalo has a winning record of 5-2 against Cleveland in its last seven games.
In five of Buffalo’s last seven games played away from home, the total has been played UNDER.
The last five games that Buffalo has played on the road versus Cleveland have resulted in a losing record as a team.
In the last twenty games that Buffalo has played against an opponent from the American Football Conference, the team has a winning record of 15-5.
There have been thirteen of Buffalo’s last eighteen games against opponents from the American Football Conference North division in which the total has turned out to be UNDER.
After seven games played on Sundays, Buffalo has a record of 5-2 against the spread.
The over/under record for Cleveland’s last 20 games is 5-15.
In its last seven games, Cleveland has a record of 1-6 against the spread.
There have been four of Cleveland’s last five home games in which the total has been above.
When playing at home against Buffalo, Cleveland has a winning record of 4-1 straight up in its last five games.
In the last 15 games that Cleveland has played against an opponent from the American Football Conference, the team has a record of 2-13 on the season.
All nine of Cleveland’s most recent ten games against teams from the American Football Conference East division have resulted in the total going over the point spread.
With seven games played in December, Cleveland has a record of 0-7 against the spread.
During the 16th week of the season, Cleveland had a record of 2-6 against the spread.

Buffalo Bills vs Cleveland Browns Odds

Now, we have the Buffalo Bills vs Cleveland Browns odds:

TEAM	SPREAD	MONEYLINE	TOTAL
Bills	-10	-520	42 O
Browns	+10	+405	42 U

Buffalo Futures Odds

Buffalo Division Odds

Now, we have the Buffalo Division Odds:

TEAM	DIVISION ODDS
Buffalo Division Odds	+200

Buffalo AFC Championship Odds

Now, we have the Buffalo AFC Championship Odds:

TEAM	CONFERENCE ODDS
Buffalo AFC Championship Odds	+350

Buffalo Bills vs Cleveland Browns Prediction: Head to Head

Date	Team	Opp	Close	Result	ATS/OU
Nov 20, 2022	Bills	Browns	-8 / 50.5	Won 31-23	Push / Over
Nov 10, 2019	Bills	@Browns	+3 / 42	Lost 16-19	Push / Under
Aug 17, 2018	Bills	@Browns	+3 / 41.5	Won 19-17	Won / Under
Dec 18, 2016	Bills	@Browns	+10.5 / 43.5	Lost 0-0	Won / Under
Aug 20, 2015	Bills	Browns	-2.5 / 39.5	Lost 0-0	Lost / Under
Nov 30, 2014	Bills	@Browns	+3 / 42	Lost 0-0	Won / Under
Oct 3, 2013	Bills	Browns	-3.5 / 40.5	Lost 0-0	Lost / Under
Sep 23, 2012	Bills	Browns	+2.5 / 45	Lost 0-0	Won / Under
Dec 12, 2010	Bills	@Browns	+1 / 39.5	Lost 0-0	Won / Under
Oct 11, 2009	Bills	@Browns	+6 / 41.5	Lost 0-0	Won / Under

Buffalo Bills vs Cleveland Browns Prediction: Bills Last 10 Games

Date	Opponent	Score	Spread	Total	Moneyline
12/14/25	@NE	W 35-31	L-4.5	O46.5	W-198
12/07/25	CIN	W 39-34	L-5.5	O49.5	W-218
11/30/25	@PIT	W 26-7	W-4.5	U47	W-205
11/20/25	@HOU	L 23-19	L-3.5	U46.5	L-175
11/16/25	TB	W 44-32	W-5.5	O49.5	W-230
11/09/25	@MIA	L 30-13	L-5.5	U48.5	L-225
11/02/25	KC	W 28-21	W-2.5	O48.5	W-135
10/26/25	@CAR	W 40-9	W-7.0	O47.5	W-310
10/13/25	@ATL	L 24-14	L-5.5	U48.5	L-225
10/05/25	NE	L 23-20	L-8.5	U46.5	L-380

Buffalo Bills vs Cleveland Browns Prediction: Browns Last 10 Games

Date	Opponent	Score	Spread	Total	Moneyline
12/14/25	@CHI	L 31-3	L+7.0	U42.5	L+240
12/07/25	TEN	L 31-29	L-1.5	O41.5	L-120
11/30/25	SF	L 26-8	L+6.0	U43.5	L+205
11/23/25	@LV	W 24-10	W+3.5	U41.5	W+142
11/16/25	BAL	L 23-16	W+8.5	U44.5	L+300
11/09/25	@NYJ	L 27-20	L+2.5	O40.5	L+114
10/26/25	@NE	L 32-13	L+5.5	O42.5	L+180
10/19/25	MIA	W 31-6	W+1.5	U43.5	W+102
10/12/25	@PIT	L 23-9	L+6.5	U42.5	L+225
10/05/25	MIN	L 21-17	W+7.0	U40.5	L+270

Buffalo Bills vs Cleveland Browns Prediction: Bills Offense

Overall

BUF Offense	Off. Rank	Stat	Def. Rank	CLE Defense
29.36	3	Points Scored	19	23.71
222.71	13	Passing Yards	1	169.00
158.50	1	Rushing Yards	14	110.14
33:13	2	Time on Field	20	30:47
63.36	11	Number of Plays	8	59.57
6.02	4	Yards Per Play	4	4.69

Scoring

BUF Offense	Off. Rank	Stat	Def. Rank	CLE Defense
29.36	3	Points Scored	19	23.71
5.07	10	First Quarter	26	5.86
7.00	16	Second Quarter	3	4.57
7.79	1	Third Quarter	27	5.93
9.50	1	Fourth Quarter	22	7.36

Passing

BUF Offense	Off. Rank	Stat	Def. Rank	CLE Defense
222.71	13	Passing Yards	1	169.00
29.43	25	Pass Attempts	3	27.86
20.50	15	Pass Completions	2	17.57
2.36	19	Sacks	3	3.36
15.14	14	Sack Yards	31	22.86
10.86	11	Yards Per Pass	8	9.62

Rushing

BUF Offense	Off. Rank	Stat	Def. Rank	CLE Defense
158.50	1	Rushing Yards	14	110.14
31.57	1	Rush Attempts	26	28.36
5.02	2	Yards Per Rush	6	3.88

Turn Overs

BUF Offense	Off. Rank	Stat	Def. Rank	CLE Defense
0.71	16	Interceptions	15	0.71
1.21	25	Fumbles	7	1.21
0.57	23	Fumbles Lost	18	0.43
1.29	18	Total Turnovers	19	1.14
6.36	12	Penalties	3	7.86
53.21	18	Penalty Yards	13	53.86

Drives & Special Teams

BUF Offense	Off. Rank	Stat	Def. Rank	CLE Defense
33:13	2	Time on Field	20	30:47
63.36	11	Number of Plays	8	59.57
6.02	4	Yards Per Play	4	4.69
2.86	4	Punts	2	4.93
44.45	27	Punt Average	20	47.49
136.29	9	Return Yards	23	136.71

Buffalo Bills vs Cleveland Browns Prediction: Browns Offense