49ers vs Saints Prediction NFL Week 2 Predictions. Place a bet on this game with the best lines and bonuses at YouWager.lv.

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49ers vs Saints Prediction NFL Week 2 Predictions

• The 49ers defeated the Seahawks on the road in Week 1 to get their first victory of the season. The Seattle offense was kept to just 230 yards by the defense of the Niners, which provided their attack with a sufficient margin for error to secure the victory in the final moments.
• The New Orleans team was unable to score any points in the red zone during their defeat at the hands of the Arizona Cardinals. New Orleans’ red zone efforts were successful one out of every four times, and the fact that quarterback Spencer Rattler does not have a lot of experience did not help them in high-pressure circumstances. At this point, he will attempt to bounce back.
• Christian McCaffrey was labeled as questionable for Week 1 due to a calf problem, but he ended up playing and accumulating a total of 142 yards. His appearance in that game was impressive, and it would not be surprising if he were to play in this competition as well.
• The Saints’ left guard, Trevor Penning, and edge rusher Chase Young have both been ruled out for the first week. This week, their prospects of securing a victory could be seriously damaged by being an underdog and lacking important players.

The offense of the San Francisco 49ers discovered a new asset in the form of Ricky Pearsall. During the first week, Pearsall snagged four passes for a total of 108 yards. Pearsall has a great deal to offer on his own merit, despite the fact that he does not pose as multifaceted a threat as Deebo Samuel did.
Statistics for the Quarterbacks During Week 1, Brock Purdy completed 26 of his 35 throw attempts. He completed passes totaling 277 yards, two touchdowns, and two interceptions. Purdy will need to be very careful with the football in this game since he cannot afford to allow the Saints any additional opportunities to score as a result of turnovers.

At the end of August, Spencer Rattler was given the QB1 position with the Saints. In the first week, he completed 27 of the 46 passes that he attempted against the Cardinals, racking up 214 passing yards and not throwing a single touchdown pass. Rattler had multiple opportunities to tie the score in the last moments of play, but he was unable to finish any of those attempts. Rattler did not throw any interceptions in week one of the season, and ball security may be the deciding factor in whether or not New Orleans can stay close in this game.

• The 49ers defeated the Seahawks in Week 1 while playing on the road and covered the spread in the process.
• New Orleans failed to cover the spread when they played Arizona at their home field.
• The sum was not surpassed by any team during their first games of the season.

49ers vs Saints Prediction NFL Week 2 Predictions: Head to Head

Date	Opponent	Score	Spread	Total	Moneyline
8/18/24	@SF	SF 16-10	SF-2.5	U36.5	SF-135
11/27/22	@SF	SF 13-0	SF-4.5	U41.5	SF-210
11/15/20	@NO	NO 27-13	NO-9.5	U48.5	NO-455
12/08/19	@NO	SF 48-46	NO-2.5	O44.5	NO-130
11/06/16	@SF	NO 41-23	NL	NL	NL
11/09/14	@NO	SF 27-24	NL	NL	NL
11/17/13	@NO	NO 23-20	NL	NL	NL
11/25/12	@NO	SF 31-21	NL	NL	NL
1/14/12	@SF	SF 36-32	NL	NL	NL
9/20/10	@SF	NO 25-22	NL	NL	NL

49ers vs Saints Prediction NFL Week 2 Predictions: Team Previews

From a betting perspective, the trends lean heavily in San Francisco’s favor. The 49ers have won six of their last nine against New Orleans and are 6-1 against NFC South opponents in recent matchups. On the other hand, the Saints have dropped five straight overall and are just 2-10-1 ATS in Week 2 games, making it difficult to trust them in this spot. The total has also leaned under in most of New Orleans’ recent contests, especially at home. This sets the stage for a battle where San Francisco’s discipline and defensive edge may prove too much for a struggling New Orleans squad still searching for rhythm.

49ers vs Saints Prediction NFL Week 2 Predictions: San Francisco

Now in this 49ers vs Saints Prediction NFL Week 2 Predictions, we have the San Francisco betting preview.

The San Francisco 49ers are entering Week 2 in a favorable position, carrying momentum from their gritty win over the Seahawks. Their defense held Seattle to just 230 total yards, which is a testament to their dominance in the trenches and disciplined secondary play. Brock Purdy played efficiently, though his two interceptions left the door open for late drama. Still, with Christian McCaffrey back in form and Ricky Pearsall stepping up as a promising weapon, the Niners are showing early signs of being a well-rounded contender. San Francisco has also fared well historically against the Saints, giving them both confidence and a tactical advantage heading into this matchup.

49ers vs Saints Prediction NFL Week 2 Predictions: San Francisco Trends

Next in this 49ers vs Saints Prediction NFL Week 2 Predictions, we have the San Francisco trends:

• The San Francisco team has a record of 2-8 against the spread in its most recent ten games.
• The overall score has gone beyond the predicted amount in four of the six most recent games played by San Francisco.
• Over the course of their most recent five matches, the San Francisco team has maintained a record of 1 win and 4 losses.
• Over the course of its last nine matchups versus New Orleans, San Francisco has a record of six wins, two losses, and one tie.
• The current record for San Francisco is 1–5 ATS in their previous six away games.
• The San Francisco team has a record of 4–8 straight up in its last twelve games when it has played against New Orleans on the other team’s home court.
• In their last eight games against an opponent in the National Football Conference (NFC), San Francisco has a record of two wins and six losses according to the “against the spread” (ATS) line.
• In the last seven games played against an opponent from the National Football Conference South division, San Francisco has had a winning record of six to one.
• When playing as the favorite, San Francisco has seen the total go UNDER in four of their most recent six games.

San Francisco Last 10 Games

Date	Opponent	Score	Spread	Total	Moneyline
9/07/25	@SEA	W 17-13	W-1.5	U45.5	W-124
1/05/25	@ARI	L 47-24	L-5.5	O43	L-230
12/30/24	DET	L 40-34	L-4.5	O49.5	L-205
12/22/24	@MIA	L 29-17	L-1.0	U49	L-115
12/12/24	LAR	L 12-6	L-7.0	U47.5	L-335
12/08/24	CHI	W 38-13	W-5.5	O47.5	W-230
12/01/24	@BUF	L 35-10	L-2.0	U47	L-125
11/24/24	@GB	L 38-10	L-2.5	O47	L-130
11/17/24	SEA	L 20-17	L-9.0	U47.5	L-410
11/10/24	@TB	W 23-20	L-4.0	U46.5	W-198

49ers vs Saints Prediction NFL Week 2 Predictions: New Orleans

Now in this 49ers vs Saints Prediction NFL Week 2 Predictions, we have the New Orleans betting preview.

For the Saints, Week 1 highlighted both potential and glaring weakness. Spencer Rattler showed composure and protected the football, but the inability to finish in the red zone cost New Orleans dearly against Arizona. Converting just one of four trips inside the 20-yard line underscores a problem that has haunted the Saints in recent years: efficiency under pressure. Missing key contributors like Trevor Penning and Chase Young only complicates their Week 2 outlook, leaving Rattler with more responsibility on his young shoulders. If the Saints are to pull an upset, they will need both improved offensive execution and a defensive effort capable of slowing McCaffrey and forcing Purdy into mistakes.

49ers vs Saints Prediction NFL Week 2 Predictions: New Orleans Trends

Next in this 49ers vs Saints Prediction NFL Week 2 Predictions, we have the New Orleans trends:

• In its last fourteen games, New Orleans has had an ATS record of 4 wins and 10 losses.
• The total has gone under in six of the seven most recent games played by New Orleans.
• Over the course of its last five games, New Orleans has a win-loss record of 0-5.
• Over the course of the last nine games between the New Orleans Saints and the San Francisco 49ers, the total has gone OVER six times.
• The total has gone under in five out of the last six times that New Orleans has played at home.
• In its last twelve games versus San Francisco, New Orleans has a record of 8 wins and 4 losses when playing at home.
• The New Orleans Saints have a record of 1–5 versus opponents in the National Football Conference during the course of their most recent six games.
• The New Orleans Saints have a record of 1–5 against the spread in their most recent six matchups versus opponents from the National Football Conference West division.
• In the past fourteen games that New Orleans has played in September, the total has gone under ten times.
• New Orleans has a record of 2–10–1 against the spread in the 13 games that they have played in week two.

New Orleans Last 10 Games

Date	Opponent	Score	Spread	Total	Moneyline
9/07/25	ARI	L 20-13	L+4.5	U41.5	L+168
1/05/25	@TB	L 27-19	L+2.5	O43	L+114
12/29/24	LV	L 25-10	L-2.0	U43	L-130
12/23/24	@GB	L 34-0	L+5.0	U45	L+180
12/15/24	WAS	L 20-19	L-2.5	U42	L-142
12/08/24	@NYG	W 14-11	W-0.5	U41	W-112
12/01/24	LAR	L 21-14	L+1.5	U46.5	L+102
11/17/24	CLE	W 35-14	W+2.0	O42	W+110
11/10/24	ATL	W 20-17	W+1.5	U44.5	W+105
11/03/24	@CAR	L 23-22	L-1.0	O40.5	L-118

 

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