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NFL Spreads Week 1 2025: Chiefs vs Chargers Betting Lines

The AFC West rivalry between the Kansas City Chiefs and Los Angeles Chargers is once again in the spotlight as both teams open the 2025 season. Oddsmakers have installed Kansas City as a three-point road favorite, a line that reflects both their dominance in recent head-to-head matchups and their September track record under Patrick Mahomes. While the spread looks tight, history tells us this series has been anything but balanced in recent years. The Chiefs have won seven straight regular season meetings and have a perfect 10-0 record when visiting the Chargers in Los Angeles.

For bettors, the spread of -3 suggests a competitive contest, but Kansas City’s ability to grind out close wins cannot be overlooked. In fact, the Chiefs have won 17 of their last 20 games straight up, proving they are not only consistent but profitable on the moneyline. The -170 line on Kansas City may not deliver big value, but it reflects the reliability of Mahomes and Andy Reid’s squad in season openers.

The Chargers, meanwhile, come into this matchup looking to break a decade-long home losing streak to the Chiefs. Their +150 moneyline offers strong underdog value for bettors willing to back Los Angeles finally turning the tide. With a 9-3 run over their last 12 games and a defense that finished second in points allowed last year, there is at least some justification for taking that risk. The key will be whether Justin Herbert and the offense can put up points early. The Chargers have been successful in overs recently, with five straight games hitting the total, while Kansas City has leaned to the under in 10 of its last 14.

The over/under of 45.5 is another intriguing angle. Kansas City’s offensive production dipped slightly last season, particularly in the rushing game, but the Chargers’ defense showed some cracks against high-powered quarterbacks. At the same time, five of the last six meetings between these teams have finished under the total. Bettors face a classic dilemma: trust long-term head-to-head trends or ride the Chargers’ recent scoring surge.

In terms of divisional betting history, Kansas City has struggled against the spread within the AFC West, going 0-5 ATS in its last five such contests. The Chargers, however, are 5-0-1 ATS in their last six divisional games, showing they often keep things close even when they don’t win outright.

Ultimately, the Chiefs enter Week 1 as the safer bet, but the Chargers provide the better value if you’re chasing an upset. With Mahomes’ September dominance against Herbert’s desperation to finally beat Kansas City at home, this game sets up as one of the marquee matchups of the opening slate. Whether you lean toward Kansas City covering or Los Angeles breaking the streak, expect a hard-fought divisional clash where every possession matters.

Chiefs vs Chargers Week 1 NFL Spreads 2025

Now in these Chiefs vs Chargers Betting Prediction, we have the Week 1 NFL Spreads 2025:

TEAM	SPREAD
Chiefs	-3
Chargers	+3

NFL Spreads Week 1 2025: Favorite Prediction

When it comes to picking the favorite in Chiefs vs Chargers, Kansas City checks nearly every box. The Chiefs’ -3 spread feels modest when you consider how thoroughly they’ve dominated this rivalry. Kansas City has beaten Los Angeles in seven straight regular-season games and is 10-0 in its last 10 road trips against the Chargers. Those numbers aren’t just impressive—they’re overwhelming. Bettors who look at history, quarterback play, and coaching consistency will see Kansas City as the clear favorite worth backing.

Patrick Mahomes remains the single most important factor in this matchup. The Chiefs’ offense may not have been at its peak last season, but Mahomes’ ability to deliver in clutch situations separates Kansas City from the pack. His track record in September is particularly strong, as the Chiefs typically start fast and set the tone early in the year. Combined with Andy Reid’s scheming and an experienced defense that consistently keeps games low-scoring, Kansas City has the tools to cover this modest spread.

Another key factor is the Chiefs’ ability to win close games. Even when they’ve struggled to cover larger spreads, Kansas City continues to rack up straight-up wins. Their 17-3 record in their last 20 games overall shows how rarely this team slips up. For a spread of only -3, the Chiefs don’t need to dominate—they just need to secure a victory by a field goal or more, something they’ve done time and again against Los Angeles.

The defensive matchup also favors Kansas City. The Chargers’ late-season offensive explosion may not hold up against a Chiefs unit that finished top-five in points allowed last year. Kansas City has been especially strong in keeping AFC opponents under the total, with six of its last eight matchups against the conference finishing below the number. If the Chiefs’ defense can limit Herbert’s big plays and force Los Angeles into long drives, Mahomes will have enough opportunities to tilt the game in Kansas City’s favor.

While the Chargers have had recent ATS success in divisional contests, history and consistency point toward Kansas City. Los Angeles’ inability to win at home against the Chiefs looms too large to ignore. Add in Kansas City’s 4-1-1 ATS record in September over their last six, and the trend suggests they typically reward bettors early in the year.

The -170 moneyline may not deliver the same return as an underdog play, but for bettors looking for stability, Kansas City is the trustworthy side. The spread of -3 offers just enough value to back Mahomes and the Chiefs with confidence. This is a game where the favorite should deliver, continuing Kansas City’s dominance over its division rival.

NFL Spreads Week 1 2025: Underdog Prediction

If you’re looking for value in Week 1, the Los Angeles Chargers offer it. Priced at +150 on the moneyline and catching three points at home, the Chargers have the offensive firepower and defensive backbone to make this rivalry closer than the market expects. While Kansas City has historically owned this matchup, Los Angeles’ recent form suggests they can at least cover, if not finally break through with a long-awaited win.

The Chargers’ best case rests on their balance. Justin Herbert remains one of the league’s most talented quarterbacks, and when paired with their recent surge in offensive production, Los Angeles has proven it can light up the scoreboard. Over their last five games of 2024, every total went over as the Chargers rediscovered their scoring groove. They averaged more than 30 points in several late-season victories, including a dominant 40-7 win at New England. Against a Chiefs team that has leaned toward unders, Los Angeles can use tempo and vertical passing to dictate the pace.

Defensively, the Chargers are no pushover. They finished second in points allowed last season and have shown they can frustrate opposing quarterbacks with pressure and timely takeaways. Their ability to keep games close has translated into betting success within the division, going 5-0-1 ATS in their last six AFC West matchups. That’s a notable edge when facing Kansas City, who has struggled to cover in divisional games despite winning outright.

The main challenge, of course, is history. Ten straight home losses to Kansas City weigh heavily, as do seven straight overall defeats. But betting on underdogs often means identifying when trends could finally break. The Chargers’ strong finish to last season, combined with Kansas City’s occasional letdowns against the spread, make this the right spot to gamble.

From a betting perspective, the +3 line has strong push protection, as several of the recent meetings have been decided by a field goal. Los Angeles’ moneyline at +150 provides even greater value for those looking to back an outright upset. Given how many of these games have finished within one score, the Chargers are a worthwhile play.

The matchup boils down to whether you trust Kansas City to continue their dominance or believe the Chargers are due for regression in the series. For bettors chasing underdog value, Los Angeles is the smarter side. With Herbert capable of going toe-to-toe with Mahomes and a defense built to keep things tight, the Chargers provide legitimate upset potential in Week 1.

Chiefs vs Chargers Betting Lines: Moneyline and Total

Now on this article on NFL Spreads Week 1 2025, we also have the other two Chiefs vs Chargers betting lines, moneyline and total:

Chiefs vs Chargers Betting Lines: Moneyline

TEAM	MONEYLINE
Chiefs	-170
Chargers	+150

Chiefs vs Chargers Betting Lines: Total

OVER / UNDER
46 ½ O
46 ½ U

NFL Spreads Week 1 2025: Survivor Pool Picks

Now in this article on NFL Spreads Week 1 2025, we have the best Week 1 NFL survivor pool picks:

NFL Spreads Week 1 2025 Survivor Pool Picks: Denver Broncos

The Denver Broncos are going to be the very first official pick from the pool of survivors. They are the most eagerly awaited team during the first week, and for a very good reason. Tennessee has issues on both offense and defense, and they did not obtain enough new players over the off-season to boost their prospects of competing against a team like Denver. The Broncos have their sights set on winning the Super Bowl this season, and in order to accomplish this goal, they must focus on shutting down Cam Ward, a rookie quarterback. Bo Nix will make an absolutely spectacular impression in the first game of his sophomore season, and it is beyond comprehension that the Broncos will suffer a defeat on their own turf any time soon. Despite the fact that this is going to be a square and a popular pick this week, there are instances when this is the most appropriate option. We have an abundance of time to deviate from the standard approach, and there is no reason to be polite because every single one of the entries is still in existence.

NFL Spreads Week 1 2025 Survivor Pool Picks: Washington Commanders

The New York Giants have no chance at all of overcoming the Washington Commanders in the first week. It is often a good idea to steer clear of divisional games when participating in survival pools. Jayden Daniels gained notoriety for his contributions to Washington during the season that had just finished, and the team he plays for has achieved even more success than it did in the year before. There is a possibility that the Commanders will not be able to replicate the fantastic season that they experienced in the year prior; however, they will have the opportunity to start off the season with a win that will make them feel good in front of their home crowd.

NFL Spreads Week 1 2025 Survivor Pool Picks: Arizona Cardinals 

This season, one of the most popular techniques will be to place a bet against the New Orleans Saints, and even a team that is not extremely strong, such as the Cardinals, can make this appear to be an easy bet. A breakout season from Kyler Murray has not been seen in quite some time, and there is a possibility that one will never occur. Both Tyler Shough and Spencer Rattler have proven to be disappointing players; meanwhile, Murray has failed to meet the expectations that people have set for him. The New Orleans Saints are experiencing a lack of youthful promise as well as financial difficulties. The team is also in danger of finishing the season with a winless record of 0–17. If you are looking to steer clear of the Broncos, this is not a terrible option considering Arizona does not have many games on their schedule that are less challenging than this one.

NFL Spreads Week 1 2025 Survivor Pool Picks: Kansas City Chiefs

Patrick Mahomes and his teammates are not going to let the humiliating defeat that the Kansas City Chiefs suffered in the Super Bowl the previous season prevent them from utterly annihilating the Los Angeles Chargers. The Chiefs have outperformed the Chargers in recent years, but there is always a chance that the international twist will throw a curveball into this matchup. Despite this, making use of the Chiefs in week one is not a smart strategy due to the fact that there are other options accessible that are safer.

NFL Spreads Week 1 2025 Survivor Pool Picks: New England Patriots 

When it comes to this game, there are many reasons to feel hopeful about the Patriots. It is a possibility that Geno Smith may need a certain amount of time to become accustomed to a new offense because Drake Maye has been performing increasingly well with each appearance that he has made on the field. On top of that, the defensive advantages of the Patriots will make making the switch even more challenging than it would be otherwise. New England will maintain a large edge in the game as a consequence of the fact that this will be a game in which scores will be low and inches will play a significant role. Be on the side of the Patriots to win the game, since they are the selection of the week and are going up against the common consensus. They are the squad to go with if you are looking to cause an upset in Week 1.

NFL Spreads Week 1 2025 Survivor Pool Picks: Indianapolis Colts

The Indianapolis Colts are going to begin the season by putting Daniel Jones in the game during the first week, which is very unexpected. Anthony Richardson is a talented young athlete, and Jones is a reliable starter in the National Football League. However, this is a controversial decision to make with the future in mind. At the moment, there are serious issues on both sides of the ball, in the locker room, and in pretty much every other part of the Dolphins’ organization. The entire field is plagued by these issues that are impacting the Dolphins. The Colts have a slight edge in every position, which will be enough to secure a win on their home turf. The team’s morale would surely improve if they were able to achieve a positive result in the first week, but the Colts perform better as a whole.

NFL Spreads Week 1 2025 Survivor Pool Picks: Philadelphia Eagles 

This is what the best course of action to avoid throughout this week is to avoid. The Eagles are going to have a difficult time if they go up against a Cowboys club that is desperate to win in the Super Bowl. Dallas is going to be far better than the majority of people anticipate this season, and I would not be in the slightest bit surprised if they were victorious over the team that is now in the championship. This game is going to be much closer to a tie than the spread implies it would be due to the fact that the Cowboys are one of the few teams that have the ability to match the kind of physicality that the Eagles bring to the field. That being stated, the Eagles continue to be a really powerful group, and they will most likely discover a method to achieve their goals.

NFL Spreads Week 1 2025 Survivor Pool Picks: Pittsburgh Steelers

What kind of image will Aaron Rodgers project to the general public if he joins the Steelers? I expect that the future Hall of Famer will have a better beginning to his game than he did two years ago in his first game with the Jets, which will give him the opportunity to thrive. His defense is adequate enough for him to achieve success. It would seem that the only viable alternative for New York is to deploy quarterback Justin Fields, but he would appear to be completely powerless when he is up against a powerful defense like the one that belongs to the Steelers.

NFL Spreads Week 1 2025 Survivor Pool Picks: Chicago Bears

This Monday night is the last night of Week 1 for both the Bears and the Vikings, and this week, Chicago is a fantastic team to go after. Following a year spent on the bench, the Minnesota team is uncertain about the performance they can expect from JJ McCarthy. On the other hand, Caleb Williams demonstrated remarkable skills in primetime games throughout the previous season. Over the course of the offseason, the Chicago Bears made a number of modifications on both sides of the ball. The Minnesota Vikings will have big hurdles as a result of the improved defense that Chicago has put together. Even if there are options available that are more secure, I would not be surprised if you choose to go with the Bears this week.

NFL Spreads Week 1 2025 Survivor Pool Picks: Cincinnati Bengals

Divisional matchups have their own unique obstacles, but when these games are played against a team like the Browns, those problems are multiplied. Joe Burrow and the Bengals, on the other hand, are running out of time to deliver results that can be quantified, while Cleveland is not under any pressure to start the season. When they take on the field, it is going to be a filthy and slow game for Cleveland, and it is going to be an uphill battle for the team who plays them because the Browns are a strong team. What are the chances that the Bengals will come out on top in this game? That is true. Will you be putting the safety of those who survived squarely on their shoulders? There is no question about that.

NFL Spreads Week 1 2025 Survivor Pool Picks: Los Angeles Rams

This game will carry a great deal of importance for the playoffs at an early stage in the season due to the fact that both of these clubs are seen as underdogs this year. Even if it is very probable that CJ Stroud will make a recovery from the sophomore slump that he encountered in the previous year, it is impossible to overlook Matthew Stafford and the team of athletes that are members of the Rams. The Rams have just finished retooling an offensive unit that was already incredibly powerful in order to make it even more effective. They are now able to score thirty or more points at home with ease.

NFL Spreads Week 1 2025 Survivor Pool Picks: Atlanta Falcons

Atlanta will have the benefit of playing at home for this divisional match-up in Georgia, and they will be able to put their minds to it and come out on top. The Tampa Bay club has a wide variety of offensive skills to pick from; nevertheless, their lack of run stoppers will present Bijan Robinson with a wealth of opportunity to succeed. The Falcons will have lost the game in the second half if Michael Penix Jr. is able to provide them with the opportunity to grab the lead.

NFL Spreads Week 1 2025 Survivor Pool Picks: Green Bay Packers

We would most likely be betting on the Lions if this clash were to occur later on in the year. There is a chance that some misunderstandings could arise with the new coaching staff, despite the fact that Detroit have superior skills on the field. Green Bay will be competing on the intimidating turf of Lambeau Field, and they have a far higher degree of continuity from the previous season than the Lions. This squad is normally a poor choice for betting, despite the fact that there is a tiny tilt in favor of the Packers.

NFL Spreads Week 1 2025 Survivor Pool Picks: Seattle Seahawks

Sam Darnold will be given the opportunity to join the Seattle Seahawks after the team made the decision to trade Geno Smith, a move that is expected to yield a favorable return during the opening week of the season. Despite the fact that the 49ers are a team that ended the previous season with a record of seven defeats and one win, it is challenging to bet against them at any point during the current season. They have not yet come anywhere near to being in good health, and they are also dealing with the matter of suspensions. The Seattle Seahawks also have the advantage of playing this game at home, and they are up against a difficult schedule this season.

NFL Spreads Week 1 2025 Survivor Pool Picks: Jacksonville Jaguars

It would be unwise for any individual who has survived the pool to jeopardize their safety by taking part in any of these dumpster fires at this stage in the season. At this moment in time, none of these cats can be considered dependable options, but later in the season, one of them could emerge as a halfway decent alternative.

NFL Spreads Week 1 2025 Survivor Pool Picks: Baltimore Ravens

There is no way to even think about putting these two teams in a matchup that is this close to one another considering the fact that both of them are among the best in the league. If you choose to assume one of the positions during the first week in the survivor pool, you must make certain that you are aware with all of its regulations.

 

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