Chiefs vs Chargers Betting NFL Predictions Week 1 2025 Friday Night Football. Place a bet on this NFL football game with the best NFL Week 1 betting lines.

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Chiefs vs Chargers Betting NFL Predictions Week 1 2025

The opening game of the 2025 NFL season brings a heated AFC West clash between the Kansas City Chiefs and the Los Angeles Chargers on Friday Night Football.

Chiefs vs Chargers Betting NFL Predictions Week 1 2025: Head to Head

Date	Team	Opp	Close	Result	ATS/OU
Dec 8, 2024	Chargers	@Chiefs	+4.5 / 43	Lost 17-19	Won / Under
Sep 29, 2024	Chargers	Chiefs	+7 / 42	Lost 10-17	Push / Under
Jan 7, 2024	Chargers	Chiefs	-3.5 / 35.5	Lost 12-13	Lost / Under
Oct 22, 2023	Chargers	@Chiefs	+5.5 / 48.5	Lost 17-31	Lost / Under
Nov 20, 2022	Chargers	Chiefs	+5.5 / 52.5	Lost 27-30	Won / Over
Sep 15, 2022	Chargers	@Chiefs	+3.5 / 52.5	Lost 24-27	Won / Under
Dec 16, 2021	Chargers	Chiefs	+3 / 54	Lost 28-34	Lost / Over
Sep 26, 2021	Chargers	@Chiefs	+6.5 / 55	Won 30-24	Won / Under
Jan 3, 2021	Chargers	@Chiefs	-7 / 43	Won 38-21	Won / Over
Sep 20, 2020	Chargers	Chiefs	+8.5 / 47	Lost 20-23	Won / Under

NFL Week 1 Betting Lines: Chiefs vs Chargers

Now in these Chiefs vs Chargers Betting NFL Predictions Week 1 2025, we have the game odds:

Chiefs vs Chargers Betting NFL Predictions: Week 1 NFL Spreads 2025

Now in these Chiefs vs Chargers Betting NFL Predictions, we have the Week 1 NFL Spreads 2025:

TEAM	SPREAD
Kansas City	-3
Los Angeles	+3

Chiefs vs Chargers Betting NFL Predictions Week 1 2025: Moneyline

Now in these Chiefs vs Chargers Betting NFL Predictions, we have the moneyline:

TEAM	MONEYLINE
Kansas City	-170
Los Angeles	+150

Chiefs vs Chargers Betting NFL Predictions Week 1 2025: Over Under

Now in these Chiefs vs Chargers Betting NFL Predictions, we have the Week 1 Over Under:

OVER / UNDER
45.5 O
45.5 U

Chiefs vs Chargers Betting NFL Predictions Week 1 2025: Team Previews

For bettors, the Chiefs vs Chargers game offers multiple angles worth considering. Kansas City’s consistency and dominance make them a trustworthy favorite, but the spread of -3 suggests a competitive game. The Chargers’ trend of hitting overs in five straight games aligns with their late-season scoring surge, while the Chiefs’ recent pattern of unders adds intrigue to the 45.5 total line. Bettors seeking value may eye the Chargers’ +150 moneyline, banking on their ability to finally break through at home. Meanwhile, Chiefs backers will point to Mahomes’ track record, the team’s elite defense, and their remarkable September record as reasons to lay the points. Whether you’re playing the spread, moneyline, or total, this matchup promises fireworks for fans and wagering opportunities for those looking to cash in.

Chiefs vs Chargers Betting NFL Predictions: Kansas City 2025 NFL Betting Preview

Now in these Chiefs vs Chargers Betting NFL Predictions, we have the Kansas City 2025 NFL Betting Preview.

Oddsmakers have placed Kansas City as a three-point road favorite, which comes as no surprise considering their recent dominance in this rivalry. The Chiefs have won seven straight regular season matchups against the Chargers and maintain a perfect 10-0 record when playing in Los Angeles. With Patrick Mahomes continuing to set the standard for elite quarterback play, Kansas City’s experience and ability to win tight games makes them an intimidating opponent. Despite occasional struggles with covering spreads in divisional contests, the Chiefs are consistently reliable straight-up, posting 17 wins in their last 20 games overall.

Chiefs vs Chargers Betting NFL Predictions: Kansas City Trends

Next in these Chiefs vs Chargers Betting NFL Predictions, we have the Kansas City trends:

• The over/under record for Kansas City’s last 14 games is 4-10.
• There have been six of Kansas City’s most recent nine games in which the total has been UNDER.
• Kansas City has a winning record of 17-3 in its previous 20 games.
• Kansas City has a perfect regular season record of 7-0 against the Los Angeles Chargers.
• Kansas City has a winning record of 11-3 on the road in its last 14 games.
• When playing on the road against the Los Angeles Chargers, Kansas City has a perfect record of 10-0 in its last ten games.
• There have been six out of the last eight games that Kansas City has played against an opponent from the American Football Conference that have ended with the total falling below par.
• During its most recent five games against teams from the American Football Conference West division, Kansas City had a record of 0-5 against the spread.
• After six games played in September, Kansas City has a record of 4-1-1 against the spread.

Kansas City Last 10 Games

Date	Opponent	Score	Spread	Total	Moneyline
2/09/25	@PHI	L 40-22	L-1.5	O49.5	L-130
1/26/25	BUF	W 32-29	W-1.5	O48.5	W-120
1/18/25	HOU	W 23-14	W-8.0	U42	W-480
1/05/25	@DEN	L 38-0	L-4.0	U46.5	L-192
12/25/24	@PIT	W 29-10	W-4.0	U41.5	W-290
12/21/24	HOU	W 27-19	W-4.5	U47	W-205
12/15/24	@CLE	W 21-7	W-3.0	U46.5	W-142
12/08/24	LAC	W 19-17	L-6.5	U44.5	W-265
11/29/24	LV	W 19-17	L-7.0	U45.5	W-340
11/24/24	@CAR	W 30-27	L-7.0	O45.5	W-310

Kansas City Chiefs Sportsbook Cash Bonuses

The Kansas City Chiefs continue to be one of the most profitable teams for bettors, especially when it comes to straight-up wins. Their dominance against the Chargers and strong overall record makes them a reliable betting choice heading into Week 1. If you’re backing Kansas City, now is the perfect time to take advantage of sportsbook cash bonuses at YouWager. With a 100% sign-up bonus when depositing with crypto, you double your bankroll instantly, giving you more opportunities to ride with Mahomes and the Chiefs. Secure your bonus today and start betting smarter with YouWager’s crypto promos.

Chiefs vs Chargers Betting NFL Predictions: Los Angeles 2025 NFL Betting Preview

Now in these Chiefs vs Chargers Betting NFL Predictions, we have the Los Angeles 2025 NFL Betting Preview.

Los Angeles Chargers enter Week 1 seeking to flip the script and make an early-season statement. They are coming off a 9-3 stretch over their last 12 games, including multiple high-scoring wins that proved their offensive ceiling remains high. The Chargers have been especially strong against the spread within the AFC West, going 5-0-1 in their last six divisional contests. However, history looms large, with ten consecutive home losses to Kansas City serving as a major psychological hurdle. The Chargers’ offensive explosiveness has been complemented by a defense that ranked second in the league in points allowed last season, but containing Mahomes and Kansas City’s second-quarter scoring bursts will be key to any potential upset.

Chiefs vs Chargers Betting NFL Predictions: Los Angeles Trends

Next in these Chiefs vs Chargers Betting NFL Predictions, we have the Los Angeles trends:

• Over the past 12 games, the Los Angeles Chargers have a 9-3 overall record.
• 5 of the last 5 games that the LA Chargers have played have seen the total go over.
• The Los Angeles Chargers have a winning record of 8-4 in their previous 12 games.
• In five of the last six games that the Los Angeles Chargers have played versus Kansas City, the total has been under.
• Five of the last six games that the Los Angeles Chargers have played at home have resulted with the total going over.
• When playing at home versus Kansas City, the Los Angeles Chargers have a losing record of 0-10 in their last ten games.
• Each of the last eight games that the Los Angeles Chargers have played against an opponent from the American Football Conference has resulted in the total going over seven times.
• In their last six games against teams from the American Football Conference West division, the Los Angeles Chargers have a record of 5-0-1 against the spread.
• During the month of September, the Los Angeles Chargers have a Super Bowl record of 3-6.
• As the underdog, the Los Angeles Chargers have a record of 2-8-1 against the spread in their previous 11 games.

Los Angeles Last 10 Games

Date	Opponent	Score	Spread	Total	Moneyline
1/11/25	@HOU	L 32-12	L-2.5	O43.5	L-148
1/05/25	@LV	W 34-20	W-1.0	O44.5	W-122
12/28/24	@NE	W 40-7	W-2.5	O41	W-135
12/19/24	DEN	W 34-27	W-3.5	O45	W-180
12/15/24	TB	L 40-17	L-3.0	O42.5	L-148
12/08/24	@KC	L 19-17	W+6.5	U44.5	L+215
12/01/24	@ATL	W 17-13	W+2.5	U47.5	W+114
11/25/24	BAL	L 30-23	L+2.0	O47	L+105
11/17/24	CIN	W 34-27	W+2.0	O45	W+110
11/10/24	TEN	W 27-17	W-4.0	O43.5	W-192

Week 1 Betting Guide: NFL Best Bets

Now, in addition to these Chiefs vs Chargers Betting NFL Predictions, we have general Week 1 betting picks:

Chiefs vs Chargers Betting NFL Predictions: Additional Week 1 Key Matchups to Watch

The first week of the season features a slate of games that will determine the overall direction of the season. A number of contests distinguish out from the rest because of the competitive spreads, huge totals, or compelling storylines that they feature.

• In the first game of the season, the Philadelphia Eagles, who are the reigning champions of the Super Bowl, will be playing the Dallas Cowboys. The Eagles are 7-point favorites over their NFC East rivals. There are a total of 46.5 points available for wagering, with the moneyline now standing at Eagles -310 and Cowboys +250. Although Philadelphia is a huge favorite due to their dominant squad and the fact that they will be playing at home, Dallas may be able to keep the game close with their rebuilt defense.
• At Buffalo Bills Stadium, the Baltimore Ravens There is a total of 51.5 points for this Sunday night matchup, making it the highest total of the week. While the Ravens are now sitting at +105, Buffalo is a modest 1.5-point favorite at home (the moneyline is -115). On both teams, Lamar Jackson and Josh Allen are the driving forces behind their powerful offenses. Will this game live up to the high-scoring expectations that we have for it?
• The Green Bay Packers playing the Detroit Lions: The spread for this game is quite close, with Detroit being favored by 1.5 points (-115 moneyline) and a total of 49.5 points across the board. This game is a classic NFC North matchup. A youthful and talented lineup is present on both sides. A home-field advantage at Lambeau Field for Green Bay could be the deciding factor in this matchup.
• At Washington Commanders, the New York Giants are playing: At the beginning of the game, Washington was a 7.5-point favorite over the Giants (+300), with a moneyline of -400. This brings the total to 45.5 points. If Jayden Daniels is spearheading a potent offensive for the Commanders, can the Giants’ defense be able to hold up when they are away from home?

Week 1 NFL Best Bets: Underdog Opportunities

Surprises are common during the first week of the season, when teams either shake off the rust or surpass expectations. When you choose your places, betting on underdogs can be profitable if you do it correctly. You should take into consideration the following underdogs.

• The line for the game between the Carolina Panthers (+140) and the Jacksonville Jaguars has changed from Jaguars -3.5 to -2.5, which indicates that gamblers are looking for value in Carolina. The Panthers are a real underdog if Bryce Young’s late-season surge in 2024 continues, as it is possible that it will carry over.
• Los Angeles Chargers (+130) at Kansas City Chiefs: The Chiefs are the favorites in Brazil by a margin of 2.5 points; however, Justin Herbert and a revitalized Chargers roster under Jim
• Harbaugh might make this game a close contest.
• Matchup between the Minnesota Vikings (+102) and the Chicago Bears: Despite the fact that Chicago has a -1.5 spread, the Minnesota Vikings are a sneaky choice to steal a road win because to their improved offensive line and the potential of J.J. McCarthy.

As a result of the uncertain characteristics of the squad, underdogs frequently succeed in Week 1. Would you be willing to put your money on one of these teams against the odds?

Week 1 Over Under NFL Totals to Target

When you want to avoid picking a side, betting on the game totals can be a sensible way to do it. The over/under lines for Week 1 are quite intriguing, and they are predicated on the offensive and defensive matchups that are involved.

• The highest total is for the game between the Ravens and the Bills, which is 51.5, because both teams have powerful offenses. The two games that took place between these teams in the previous year both scored 45 points. If the defenses begin slowly, the over appears to be an enticing option.
• This figure has the potential to increase rather rapidly due to the fact that both the Lions and the Packers have playmakers who are dynamic and secondaries that are problematic. Will the offensive team take the lead early on?
• The Texans will take on the Rams (46.5): Jared Verse is leading a powerful pass rush for the Rams, which Houston’s “revamped” offensive line is going to have to deal with. A game with fewer points scored could be favorable for the under.

Best Sunday Night Football Prop Bets

In Week 1 betting, player props offer an additional element of excitement to the game at hand. Even if certain objects are not yet completely available, here are some early angles that you should keep an eye out for.

• In light of Buffalo’s troubles against mobile quarterbacks during the previous season, Lamar Jackson (Ravens)’s rushing yards prop should be considered a good over bet. \
• There is a possibility that Puka Nacua (Rams) may encounter lighter coverage with Davante Adams opposite him, which will make the receiving yards prop intriguing.
• Prop markets will open closer to the season, so it is important to keep an eye on them. Which players do you anticipate will have a strong showing in the first week?

Factors That Could Shift the Lines

Betting lines are variable and subject to vary depending on a number of different factors. Here are some things to keep an eye on before you place your wagers.

• Due to injuries, key players such as Christian Darrisaw (Vikings) and Jalen Ramsey (Dolphins) might potentially have an effect on spreads if their status should alter.
• Roster Moves: Trades or signings have the potential to significantly alter the lines.
• Bets placed by the general public: Substantial wagers placed on favorites such as the Eagles or Commanders may cause spreads to increase, so creating value for underdogs.
• Ben Johnson (Bears) and Liam Coen (Jaguars) are two examples of new coaches who could potentially contribute to surprise team performances in the beginning of the season.

Chiefs vs Chargers Betting NFL Predictions: Best NFL Survivor Football Picks Week 1

Now in these Chiefs vs Chargers Betting NFL Predictions, we have the best Week 1 NFL survivor pool picks:

In the first week of the NFL season, some players will choose to bet on the Philadelphia Eagles (-7), which is one of the survivor pool picks. Due to the fact that the 2025 NFL schedule begins with a game versus the Dallas Cowboys, this is a popular option among players who are participating in the 2025 NFL survivor pool and may have planned out their strategy prior to the start of the season. If, on the other hand, Dak Prescott is in good condition and Dallas has a history of playing against Philadelphia, would it be a prudent NFL survivor pool strategy to use the Eagles selection for Week 1 NFL knockout pool picks, or would it be more prudent to wait until later in the season for eliminator pool picks?

The Cardinals, Broncos, Jaguars, and Buccaneers are some further NFL survivor picks that to take into consideration for Week 1. When it comes to your NFL survivor pools, which direction should you go?

We have now shifted our focus to the Survivor Football Picks for Week 1 of the National Football League:

Despite the fact that the Arizona Cardinals are coming off of an 8-9 season, are currently winning against the New Orleans Saints, and are 6-point favorites in the most recent NFL odds, the model is not recommending betting on them in Week 1 of the 2025 NFL season season. In Week 1 of NFL survivor pools, it may be a popular option to select the team that will be playing versus the Saints; but, the Cardinals are not a sure thing when they are playing away from home. In 2024, they had a record of just 2-6 when playing away from home, and they had lost five of their last seven games. Despite the fact that New Orleans finished the previous season with a record of only 5-12 overall, the Saints were victorious in three games played on their own grounds.

Since 2007, New Orleans has emerged victorious in five of the eight head-to-head contests that have taken place between the two teams. It is important to note that Arizona has only covered the spread in three of those games, indicating that these games have been competitive on average. With the Cardinals winning only 55% of the time, the model used by SportsLine projects that there will be a difference of one point between the teams. This makes Arizona a risky option for the Week 1 NFL survivor.

 

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