View our first-week Louisville vs. USC prediction to learn our thoughts on the winner and the point spread in San Diego.

• The defense of Louisville is giving up 12.3 yards per completion.
• In passing yards, the USC Trojans are ranked sixth.

LOUISVILLE VS USC PREDICTION

Make plans to see the Cardinals vs. Trojans 1 CFB game this week, which airs on FOX at 8:00 (12/27/23). San Diego’s Petco Park will host the game (CA).Louisville is 7.5 point road favorites going into this non-conference matchup with the Trojans. Find out my thoughts and suggested bets by reading on.

LOUISVILLE VS. USC MATCHUP AT A GLANCE

• Sport: College Football
• Teams: USC Trojans vs. Louisville Cardinals
• Where: Petco Park in San Diego
• Date: December 27, Wednesday

LOUISVILLE PREVIEW: CAN LOUISVILLE KEEP THINGS ROLLING?

Louisville’s record suffered after their most recent game against Florida State, dropping to 10-3. With a final score of 16–6, the Cardinals were defeated in the game. Louisville has started as the underdog in two games and as the favorite in nine others thus far. An average scoring difference of +11.2 and an ATS record of 5-7 have resulted from this. The average over/under for Louisville’s games through 13 games is 49.5 points. With an average score of 50.6 points over their games, OU has a 6-6 record.

The Cardinals offense amassed 188 yards of total offensive yardage and scored 10 first downs. They attempted 36 passes via the air, totaling 111 yards. 34 rushing attempts for 77 yards were the product of their running offense. Jack Plummer did not throw a touchdown pass against Florida State, although he did throw for 111 yards. With a completion percentage of 38.9%, he received an overall passer rating of 35.76.

In the end, Louisville’s defense gave up 232 yards in total versus Florida State. Against Louisville, Florida State tossed the ball 21 times for 55 points. The Cardinals surrendered 177 running yards while in the ground position. The Cardinals lead the league in quarterback rushes and have 33 sacks going into the game. This season, they have allowed 19.7 points per game (74th) thus far. They rank 58th in the NCAA in terms of pass defense, allowing 205.4 passing yards per contest. Louisville has so far given up 104.8 running yards per game against the run.

USC PREVIEW: CAN USC KEEP THINGS ROLLING?

Following their most recent defeat by UCLA, USC’s record now stands at 7-5. The Trojans were defeated 38–20 in the contest. This season, USC has started eight games as the favorite and three as the underdog. As of right now, their ATS record is 3-8. The average over/under for USC’s games over the past 12 games has been 66.6 points. These games have had an average total score of 76.8 points, giving OU an 8-3 record.

Against UCLA, the Trojans threw the ball 42 times for 384 yards and one touchdown in the passing game. They concluded with one rushing touchdown while averaging just 0.1 yards per carry on the ground. Caleb Williams, the quarterback, completed 31 of 42 passes for 384 yards in the loss to UCLA, earning a quarterback rating of 99.7. He also had one touchdown to the game’s total.

The Trojans’ defense allowed UCLA a total of 381 yards at the game’s conclusion. Compared to 309 yards in the passing game, the team’s run defense gave up 72 yards of rush yardage. The Trojans’ defense ranks 72nd this season after giving up an average of 185.3 running yards. When playing USC, opponents average 255.2 passing yards, and their quarterbacks have a passer rating of 104.4. They are presently ranked ninth in the NCAA for points allowed.

LOUISVILLE VS USC BETTING ODDS, TRENDS & ANALYSIS

Their five most recent road visits to USC have resulted in a 3-2 record while playing USC.

Louisville has a 0-3 record versus USC in their previous three games as the underdog.

There hasn’t been much movement in the point spreads, with Louisville and USC remaining exactly where they started, with Louisville favored by 7.5 on the road. Louisville presently has a 74% chance of winning based on the moneyline odds, with a moneyline payout of -279. On the other hand, the Trojans have an implied win percentage of 31% at a moneyline of +222.

KEY BETTING TRENDS

• Louisville is 3-7 against the spread in their last ten games played against the spread.
• Over their previous 10 home games, USC is 4-6.
• USC has a 3-7 ATS record in the 10 most recent instances in which they were the underdog.
• In their last ten games as the favorite, Louisville is 4-6.

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